Aurélien Marc
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View article: Viral Dynamic Models During <scp>COVID</scp>‐19: Are We Ready for the Next Pandemic?
Viral Dynamic Models During <span>COVID</span>‐19: Are We Ready for the Next Pandemic? Open
Mathematical models have been used for about 30 years to improve our understanding of virus‐host interaction, in particular during chronic infections. During the COVID‐19 pandemic, these models have been used to provide insights into the n…
View article: Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study
Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study Open
Fundació Lluita contra les Infeccions, IrsiCaixa, and Consorcio Centro de Investigación Biomédica en Red, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación e Universidades.
View article: Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection
Early administration of tecovirimat shortens the time to mpox clearance in a model of human infection Open
Despite use of tecovirimat since the beginning of the 2022 outbreak, few data have been published on its antiviral effect in humans. We here predict tecovirimat efficacy using a unique set of data in nonhuman primates (NHPs) and humans. We…
View article: Modèles intra-hôte du SARS-CoV-2 : le paradigme changeant de la charge virale et son implication sur la dynamique de la transmission
Modèles intra-hôte du SARS-CoV-2 : le paradigme changeant de la charge virale et son implication sur la dynamique de la transmission Open
L'émergence du SRAS-CoV-2 a entraîné une pandémie sans précédent. Avec un virus en évolution constante, il était nécessaire de trouver rapidement des moyens d'alléger le fardeau de la pandémie à la fois à l'échelle de la population en rédu…
View article: Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates Open
The impact of variants of concern (VoC) on SARS-CoV-2 viral dynamics remains poorly understood and essentially relies on observational studies subject to various sorts of biases. In contrast, experimental models of infection constitute a p…
View article: Immune Responses Associated with Mpox Viral Clearance in a Prospective Observational Cohort of People with and Without HIV in Spain
Immune Responses Associated with Mpox Viral Clearance in a Prospective Observational Cohort of People with and Without HIV in Spain Open
View article: Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain
Viral dynamics in patients with monkeypox infection: a prospective cohort study in Spain Open
View article: Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates Open
The impact of variants of concern (VoC) on SARS-CoV-2 viral dynamics remains poorly understood and essentially relies on observational studies subject to various sorts of biases. In contrast, experimental models of infection constitute a p…
View article: Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates Open
Contents 1. Dataset - Full dataset of all 78 animals infected with different strains of SARS-CoV-2 2. Monolix files - Structural models of the 5 models used - mlxtran files of the 6 models used 3. R script files - Main script used to repro…
View article: Viral Dynamics in Patients with Monkeypox Infection: A Prospective Cohort Study in Spain
Viral Dynamics in Patients with Monkeypox Infection: A Prospective Cohort Study in Spain Open
View article: COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models Open
Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic effec…
View article: Quantifying the relationship between SARS-CoV-2 viral load and infectiousness
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness Open
The relationship between SARS-CoV-2 viral load and infectiousness is poorly known. Using data from a cohort of cases and high-risk contacts, we reconstructed viral load at the time of contact and inferred the probability of infection. The …
View article: Author response: Quantifying the relationship between SARS-CoV-2 viral load and infectiousness
Author response: Quantifying the relationship between SARS-CoV-2 viral load and infectiousness Open
View article: Quantifying the relationship between SARS-CoV-2 viral load and infectiousness
Quantifying the relationship between SARS-CoV-2 viral load and infectiousness Open
The relationship between SARS-CoV-2 viral load and infectiousness is not known. Using data from a prospective cohort of index cases and high-risk contact, we reconstructed by modelling the viral load at the time of contact and the probabil…
View article: COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models Open
One year into the Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), effective treatments are still needed1–3. Monoclonal antibodies, given alone or as part of a …