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View article: Monomers, Dimers, and Oligomers of Pyroglutamate-Modified α-Synuclein Fragments Exhibit Distinct Biophysical Characteristics
Monomers, Dimers, and Oligomers of Pyroglutamate-Modified α-Synuclein Fragments Exhibit Distinct Biophysical Characteristics Open
α-Synuclein (aSyn) aggregation represents a key event in the neurodegenerative cascade of synucleinopathies. Initially, aSyn appears as an intrinsically disordered protein. However, its structural flexibility allows aSyn to either adopt α-…
View article: Bifunctional chimeras of myeloperoxidase and glucose oxidase. Antimicrobial, topological and enzymatic properties
Bifunctional chimeras of myeloperoxidase and glucose oxidase. Antimicrobial, topological and enzymatic properties Open
Enhancing the local substrate concentration is a crucial strategy in nature for facilitating the proximity of two enzymes. The substrate of the first enzyme is transformed into a by-product that travels to the active site of the second enz…
View article: Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody
Small-angle X-ray scattering of engineered antigen-binding fragments: the case of glycosylated Fab from the Mannitou IgM antibody Open
Monoclonal antibodies recognizing nonprotein antigens remain largely underrepresented in our understanding of the molecular repertoire of innate and adaptive immunity. One such antibody is Mannitou, a murine IgM that recognizes paucimannos…
View article: Self‐Assembled Peptide‐Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells
Self‐Assembled Peptide‐Gold Nanoclusters with SiRNA Targeting Telomeric Response to Enhance Radiosensitivity in Lung Cancer Cells Open
Lung cancer cells resistant to radiotherapy present a significant clinical challenge. Stable telomeric structures, maintained by the TRF2 protein, play a critical role in protecting cells from ionizing radiation. Reduced TRF2 expression in…
View article: Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment
Rad52 Acts as an Assembly Chaperone to Form and Stabilize Rad51 Filaments Through a Large C-Terminus 85-Residue Segment Open
Homologous recombination (HR) is essential for the repair of DNA double-strand breaks and the restart of stalled replication forks. A critical step in HR is the formation of Rad51 nucleofilaments, which perform homology search and strand i…
View article: A Macrocycle-Mediated Protein Cage
A Macrocycle-Mediated Protein Cage Open
Engineered protein cages are of great interest considering their diverse applications in delivery and catalysis. Here, we describe macrocycle-triggered icosahedral cage assembly of a designed β-propeller. Cage assembly was evidenced by sma…
View article: A bacterial immunity protein directly senses two disparate phage proteins
A bacterial immunity protein directly senses two disparate phage proteins Open
Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense…
View article: Probing the structural stability of R‐phycocyanin under pressure
Probing the structural stability of R‐phycocyanin under pressure Open
The red macroalgae Porphyra , commonly known as Nori, is widely used as food around the world due to its high nutrient content, including the significant abundance of colored phycobiliproteins (PBPs). Among these, R‐phycocyanin (R‐PC) stan…
View article: A versatile bacterial innate immunity protein directly senses two disparate phage proteins
A versatile bacterial innate immunity protein directly senses two disparate phage proteins Open
Eukaryotic innate immune systems use pattern recognition receptors (PRRs) to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins tha…
View article: Does <i>Acinetobacter calcoaceticus</i> glucose dehydrogenase produce self-damaging H2O2?
Does <i>Acinetobacter calcoaceticus</i> glucose dehydrogenase produce self-damaging H2O2? Open
The soluble glucose dehydrogenase (sGDH) from Acinetobacter calcoaceticus has been widely studied and is used, in biosensors, to detect the presence of glucose, taking advantage of its high turnover and insensitivity to molecular oxygen. T…
View article: Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe
Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Author response: Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe
Author response: Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Metrics Abstract Genome and epi…
View article: Supramolecular Synthons in Protein–Ligand Frameworks
Supramolecular Synthons in Protein–Ligand Frameworks Open
Supramolecular synthons, defined as reproducible intermolecular structural units, have greatly aided small molecule crystal engineering. In this paper, we propose that supramolecular synthons guide ligand-mediated protein crystallization. …
View article: Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Reviewer #2 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Reviewer #2 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Charge-Governed Solvation Behaviour of Novel AMPs
Charge-Governed Solvation Behaviour of Novel AMPs Open
Antimicrobial peptides (AMPs) are regarded as a promising alternative to conventional antimicrobials, but their mechanism of action is not completely understood. Using long-scale molecular dynamics simulations, we investigate the behavior …
View article: Reviewer #1 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Reviewer #1 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1, for which the links between structure and func…
View article: Reviewer #2 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Reviewer #2 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1, for which the links between structure and func…
View article: Reviewer #3 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Reviewer #3 (Public Review): Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1, for which the links between structure and func…
View article: Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe
Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and funct…
View article: Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Author Response: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1, for which the links between structure and func…
View article: Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe
Disordered regions and folded modules in CAF-1 promote histone deposition in S. pombe Open
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1, for which the links between structure and func…
View article: Robotic Process Automation: on the Continuity of Applications Development at SOLEIL
Robotic Process Automation: on the Continuity of Applications Development at SOLEIL Open
SOLEIL is currently in the Technical Design Report (TDR) phase of a major upgrade of the facility. In its digital transformation, the development of processes and systems with a high degree of autonomy is at the center of the SOLEIL II pro…