Aurélien Tripp
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View article: Laser Desorption-Rapid Evaporative Ionization Mass Spectrometry (LD-REIMS): A New Tool for the High-Throughput Metabolomic and Lipidomic Profiling of Live Cells
Laser Desorption-Rapid Evaporative Ionization Mass Spectrometry (LD-REIMS): A New Tool for the High-Throughput Metabolomic and Lipidomic Profiling of Live Cells Open
Understanding the dynamic cellular metabolism is essential for gaining deeper insights into inter- and intracellular functions. In recent years, mass spectrometry (MS) has become the technology of choice for the biochemical characterizatio…
View article: A New Approach to Large Multiomics Data Integration
A New Approach to Large Multiomics Data Integration Open
Data reduction and data mining are common practices for handling large-scale data from wide-ranging sources, but high-dimensional omics and imaging data sets present difficult challenges for feature extraction and data mining due to the la…
View article: SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress
SLC7A11 protects amoeboid-disseminating cancer cells from oxidative stress Open
Oxidative stress limits metastasis, and amoeboid cancer cells have been identified in a variety of cancers as a subset of metastatic cancer cells characterized by high Rho-ROCK-driven Myosin II activity. They display fast individual migrat…
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Cancer Research UK Rosetta Grand Challenge consortium list of members
View article: Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta Open
Summary:Understanding tumor heterogeneity is a major challenge that was recognized as one of the first Cancer Grand Challenges, with a call to provide solutions to visualize tumor heterogeneity. The Rosetta team took on this challenge, exp…
View article: A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis Open
Solid tumours have abnormally high intracellular [Na + ]. The activity of various Na + channels may underlie this Na + accumulation. Voltage-gated Na + channels (VGSCs) have been shown to be functionally active in cancer cell lines, where …
View article: A novel Na<sub>v</sub>1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
A novel Na<sub>v</sub>1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis Open
Solid tumours have abnormally high intracellular [Na + ]. The activity of various Na + channels may underlie this Na + accumulation. Voltage-gated Na + channels (VGSCs) have been shown to be functionally active in cancer cell lines, where …
View article: Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity
Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity Open
Background: Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and meta…
View article: TMOD-06. PRIMARY CELL LINES OF PEDIATRIC HIGH GRADE GLIOMAS (PHGGS) WITH HISTONE H3.3 MUTATIONS ARE MIMICKING INTER AND INTRA-TUMOR HETEROGENEITY
TMOD-06. PRIMARY CELL LINES OF PEDIATRIC HIGH GRADE GLIOMAS (PHGGS) WITH HISTONE H3.3 MUTATIONS ARE MIMICKING INTER AND INTRA-TUMOR HETEROGENEITY Open
Children diagnosed for pHGGs, comprising mostly tumors of the brain midline (brainstem and thalamic locations), are facing with a very dismal prognosis. Those brain cancers are bearing usually and in more than 80% of the cases the histone …