Aurora Aragón
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View article: Environmental exposure assessment in the international prospective study of Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) research consortium: Design and protocol development
Environmental exposure assessment in the international prospective study of Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) research consortium: Design and protocol development Open
CURE will provide critical insights into CKDu risk factors, supporting future research and prevention strategies. A comprehensive exposure assessment will enhance understanding of environmental contributors, guiding interventions at indivi…
View article: Single-Cell Sequencing Reveals Extensive Genetic Diversity Underlying Pediatric ALL Treatment Complexity
Single-Cell Sequencing Reveals Extensive Genetic Diversity Underlying Pediatric ALL Treatment Complexity Open
Approximately 15-20% of children with acute lymphoblastic leukemia (pALL) are not cured despite years of treatment with more than ten chemotherapeutic agents, yet bulk sequencing reveals minimal somatic variation that could explain genetic…
View article: International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study
International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study Open
The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to est…
View article: International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from population-based cross-sectional studies: a disadvantaged populations eGFR epidemiology (DEGREE) study
International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from population-based cross-sectional studies: a disadvantaged populations eGFR epidemiology (DEGREE) study Open
The d isadvantaged populations eG F R (estimated glomerular filtration rate) e pid e miology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols …
View article: Retrieving single-cells and cell clusters from cytology direct smear slides for genomic evaluation
Retrieving single-cells and cell clusters from cytology direct smear slides for genomic evaluation Open
Introduction/Objective The key role of cytopathologists is to generate diagnoses based on cytologically stained samples. However, diagnoses increasingly need genomic data in addition to morphologic information. By current methods, morpholo…
View article: Population-level detection of early loss of kidney function: 7-year follow-up of a young adult cohort at risk of Mesoamerican nephropathy
Population-level detection of early loss of kidney function: 7-year follow-up of a young adult cohort at risk of Mesoamerican nephropathy Open
Background Mesoamerican nephropathy is a leading contributor to premature mortality in Central America. Efforts to identify the cause are hampered by difficulties in distinguishing associations with potential initiating factors from common…
View article: O-132 7-year followup in a young adult population at risk of mesoamerican nephropathy
O-132 7-year followup in a young adult population at risk of mesoamerican nephropathy Open
Introduction Mesoamerican Nephropathy is a leading contributor to premature mortality in Central America, but the primary cause remains unclear. Early disease is challenging to identify given variation in eGFR both within and between healt…
View article: Decline in Kidney Function among Apparently Healthy Young Adults at Risk of Mesoamerican Nephropathy
Decline in Kidney Function among Apparently Healthy Young Adults at Risk of Mesoamerican Nephropathy Open
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of …
View article: Effect of informal employment on the relationship between psychosocial work risk factors and musculoskeletal pain in Central American workers
Effect of informal employment on the relationship between psychosocial work risk factors and musculoskeletal pain in Central American workers Open
Exposure to adverse levels of psychosocial work risk factors is associated with higher prevalence of MPS among both formal and informal workers. However, the role of employment informality in this association is complex and requires furthe…
View article: Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy
Renal Morphology, Clinical Findings, and Progression Rate in Mesoamerican Nephropathy Open
This study confirms the renal morphology of MeN: chronic glomerular and tubulointerstitial damage with glomerulosclerosis and chronic glomerular ischemia. Follow-up data show that eGFRs, on average, deteriorated.
View article: Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua
Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua Open
Conducting a community based study of this type requires active the involvement of communities and commitment from local leaders. Furthermore, a research team with strong links to the area and broad understanding of the context of the prob…
View article: Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua
Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua Open
Objectives To study Mesoamerican nephropathy (MeN) and its risk factors in three hot occupations. Design Cross-sectional. Setting Chinandega and León municipalities, a MeN hotspot on the Nicaraguan Pacific coast, January–February 2013. Par…