María Segunda Aurora‐Prado
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UHPLC-MS/MS chemical profiling, preliminary toxicity, <i>in vitro</i> antioxidant potential and antimicrobial activity of <i>Brachyotum naudinii</i> Triana flowers Open
Chemical compounds of Brachyotum naudinii Triana flowers were analyzed using UHPLC-MS/MS. Anthocyanin dry extract was obtained by accelerated solvent extraction with 70% ethanol acidified with citric acid (pH 3.18) and then spray dried. Pr…
Validation, measurement uncertainty estimation and evaluation of UHPLC greenness for simultaneous determination of metoprolol tartrate and hydrochlorothiazide in binary tablet Open
A novel green ultra high performance liquid chromatography (UHPLC) method was validated and estimated the measurement uncertainty for simultaneous determination of metoprolol tartrate (MET) and hydrochlorothiazide (HCT) in binary tablet. A…
Development and validation of a UV spectrophotometric method for biowaiver studies in pyrazinamide tablets Open
Context: For regulatory reasons, a biowaiver is characterized as the substitution or exemption of bioavailability and/or bioequivalence research with in vitro dissolution tests, according to the Biopharmaceutical Classification System (BCS…
View article: Application of capillary zone electrophoresis to determine second-generation H1 antihistaminic drugs, loratadine and rupatadine
Application of capillary zone electrophoresis to determine second-generation H1 antihistaminic drugs, loratadine and rupatadine Open
The second generation of H1 antihistamines from the piperidine group are often used for treating allergic diseases due to their action on histaminic receptors, the primary mediator of allergy. Moreover, the antihistamines have anti-inflamm…
Antioxidant and photoprotective potential of Polypodium leucotomos Open
In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and photoprotective properties. Electronic l…
View article: Application of capillary zone electrophoresis to determine second-generation H1 antihistaminic drugs, loratadine and rupatadine
Application of capillary zone electrophoresis to determine second-generation H1 antihistaminic drugs, loratadine and rupatadine Open
The second generation of H1 antihistamines from the piperidine group are often used for treating allergic diseases due to their action on histaminic receptors, the primary mediator of allergy. Moreover, the antihistamines have anti-inflamm…
View article: Simultaneous determination of abamectin homologs H 2 B 1a and H 2 B 1b in gel formulation by high performance liquid chromatography
Simultaneous determination of abamectin homologs H 2 B 1a and H 2 B 1b in gel formulation by high performance liquid chromatography Open
Abamectin is a drug with antiparasitic properties used in several pharmaceutical formulations. The objective of this research was to develop and validate a high performance liquid chromatographic (HPLC) method for quantification of the two…
View article: Development of analytical method by free solution capillary electrophoresis for furosemide under stress degradation
Development of analytical method by free solution capillary electrophoresis for furosemide under stress degradation Open
A fast, economical, precise and accurate free solution capillary electrophoresis method with photodiode array detector was developed and validated for the determination of furosemide in tablets. The separation was achieved by using a fused…
Shouldn't we be using more capillary electrophoresis nowadays? Open
Capillary Electrophoresis (CE) has been used for different and specific applications presenting also some specific advantages, but it is still an underestimated technique in the analytical fields.We have explored recent applications and ad…
View article: Simultaneous determination of abamectin homologs H 2 B 1a and H 2 B 1b in gel formulation by high performance liquid chromatography
Simultaneous determination of abamectin homologs H 2 B 1a and H 2 B 1b in gel formulation by high performance liquid chromatography Open
Abamectin is a drug with antiparasitic properties used in several pharmaceutical formulations. The objective of this research was to develop and validate a high performance liquid chromatographic (HPLC) method for quantification of the two…
View article: Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: drug delivery and cytotoxicity assays
Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: drug delivery and cytotoxicity assays Open
Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis–encapsulation processes.