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View article: Eps2Fold: a rapid method to characterize G-quadruplex DNA structures using single absorbance spectra
Eps2Fold: a rapid method to characterize G-quadruplex DNA structures using single absorbance spectra Open
G-rich oligonucleotides can fold into non-canonical secondary structures called G-quadruplexes (G4s), consisting of stacked G-tetrads, i.e. planar arrays of four guanines connected by eight hydrogen bonds and coordinating cations such as K…
View article: Therapeutic siRNA quantification in lipid nanoparticles using ion-pair reversed-phase chromatography
Therapeutic siRNA quantification in lipid nanoparticles using ion-pair reversed-phase chromatography Open
View article: Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties
Dibenzoacridinium Derivatives as a New Class of G-Quadruplex Ligands with Antiviral Properties Open
View article: Aptamer-based nanotrains and nanoflowers as quinine delivery systems
Aptamer-based nanotrains and nanoflowers as quinine delivery systems Open
View article: Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection Open
G-quadruplexes (G4s) are four-stranded nucleic acid structures formed by the stacking of G-tetrads. Here we investigated their formation and function during HIV-1 infection. Using bioinformatics and biophysics analyses we first searched fo…
View article: Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity
Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity Open
View article: The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology
The beginning and the end: flanking nucleotides induce a parallel G-quadruplex topology Open
Genomic sequences susceptible to form G-quadruplexes (G4s) are always flanked by other nucleotides, but G4 formation in vitro is generally studied with short synthetic DNA or RNA oligonucleotides, for which bases adjacent to the G4 core ar…
View article: Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data
Thermal and pH Stabilities of i‐DNA: Confronting in vitro Experiments with Models and In‐Cell NMR Data Open
Recent studies indicate that i‐DNA, a four‐stranded cytosine‐rich DNA also known as the i‐motif, is actually formed in vivo; however, a systematic study on sequence effects on stability has been missing. Herein, an unprecedented number of …
View article: Author Correction: Involvement of G-quadruplex regions in mammalian replication origin activity
Author Correction: Involvement of G-quadruplex regions in mammalian replication origin activity Open
View article: Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives
Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives Open
A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vit…
View article: TGF‐β‐induced fibrotic stress increases G‐quadruplex formation in human fibroblasts
TGF‐β‐induced fibrotic stress increases G‐quadruplex formation in human fibroblasts Open
Scar formation after wound healing is a major medical problem. A better understanding of the dynamic nuclear architecture of the genome during wound healing could provide insights into the underlying pathophysiology and enable novel therap…
View article: Involvement of G-quadruplex regions in mammalian replication origin activity
Involvement of G-quadruplex regions in mammalian replication origin activity Open
View article: Sweet G-quadruplex ligands as effective antiparasitic drugs
Sweet G-quadruplex ligands as effective antiparasitic drugs Open
View article: Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum
Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum Open
G-quadruplexes (G4) are non-canonical DNA and/or RNA secondary structures formed in guanine-rich regions. Given their over-representation in specific regions in the genome such as promoters and telomeres, they are likely to play important …
View article: Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells
Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells Open
G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest and cell death induced by these ligands remain large…
View article: More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand
More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand Open
Guanine-rich nucleic acid sequences can fold into four-stranded G-quadruplex (G4) structures. Despite growing evidence for their biological significance, considerable work still needs to be done to detail their cellular occurrence and func…
View article: Fishing for G‐Quadruplexes in Solution with a Perylene Diimide Derivative Labeled with Biotins
Fishing for G‐Quadruplexes in Solution with a Perylene Diimide Derivative Labeled with Biotins Open
A new fluorescent, non‐cytotoxic perylene diimide derivative with two biotins at the peri position, PDI2B , has been synthesized. This molecule is able to interact selectively with G‐quadruplexes with scarce or no affinity towards single‐ …
View article: Quadruplexes in ‘Dicty’: crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome
Quadruplexes in ‘Dicty’: crystal structure of a four-quartet G-quadruplex formed by G-rich motif found in the Dictyostelium discoideum genome Open
Guanine-rich DNA has the potential to fold into non-canonical G-quadruplex (G4) structures. Analysis of the genome of the social amoeba Dictyostelium discoideum indicates a low number of sequences with G4-forming potential (249-1055). Ther…
View article: G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents Open
G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the gen…
View article: CCDC 1838265: Experimental Crystal Structure Determination
CCDC 1838265: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: NMR And Biophysical Studies Of G-Quadruplex DNA Within The KRAS Proto-Oncogene Promoter Region
NMR And Biophysical Studies Of G-Quadruplex DNA Within The KRAS Proto-Oncogene Promoter Region Open
The role of G-quadruplexes (G4) which can coexist with canonical duplex DNA in the human genome is still largely unknown. Although G4s are found throughout the entire genome, much of the attention have been invested in promotor regions of …
View article: CCDC 782553: Experimental Crystal Structure Determination
CCDC 782553: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1017432: Experimental Crystal Structure Determination
CCDC 1017432: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1017433: Experimental Crystal Structure Determination
CCDC 1017433: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1017431: Experimental Crystal Structure Determination
CCDC 1017431: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …