Austen L. Michalak
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View article: Cell surface photoengineering enables modeling of glycocalyx shedding dynamics
Cell surface photoengineering enables modeling of glycocalyx shedding dynamics Open
Engineering cell surfaces with light-responsive mucin mimetic glycopolymers enables modeling of mucosal glycocalyx shedding and its possible roles in mucosal epithelium protection.
View article: Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments
Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments Open
Extracellular glycans, such as glycosaminoglycans (GAGs), provide an essential regulatory component during the development and maintenance of tissues. GAGs, which harbor binding sites for a range of growth factors (GFs) and other morphogen…
View article: Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments
Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments Open
Extracellular glycans, such as glycosaminoglycans (GAGs), provide an essential regulatory component during the development and maintenance of tissues. GAGs, which harbor binding sites for a range of growth factors and other morphogens, hel…
View article: Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists
Silencing glycosaminoglycan functions in mouse embryonic stem cells with small molecule antagonists Open
View article: Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State
Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State Open
Recently, the field of stem cell-based regeneration has turned its attention toward chemical approaches for controlling the pluripotency and differentiation of embryonic stem cells (ESCs) using drug-like small molecule modulators. Growth f…
View article: Establishing a cellular microarray to visualize glycan mediated signaling in mouse embryonic stem cells
Establishing a cellular microarray to visualize glycan mediated signaling in mouse embryonic stem cells Open
Glycosaminoglycan (GAG) mediated growth factor signaling initiates differentiation in embryonic stem cells (ESCs). Manipulation of the GAG interactome affords a novel tool to understand and direct stem cell differentiation. In this study, …