Austin G. Stack
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View article: #3715 Burden of chronic kidney disease and related urinary disorders on healthcare utilisation in Ireland: a national inpatient analysis
#3715 Burden of chronic kidney disease and related urinary disorders on healthcare utilisation in Ireland: a national inpatient analysis Open
Background and Aims Chronic kidney disease and related urinary tract disorders (CKD-RD) significantly impact healthcare systems worldwide. In Ireland, there is little data on the burden and impact of CKD-RD on healthcare utilisation, thus …
View article: #3901 Impact of adoption of European Kidney Consortium equation (EKFC) equation compared to CKD-EPI equations on CKD prevalence and staging in Irish adults
#3901 Impact of adoption of European Kidney Consortium equation (EKFC) equation compared to CKD-EPI equations on CKD prevalence and staging in Irish adults Open
Background and Aims The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation tends to overestimate glomerular filtration rate (GFR) in younger and older age groups. In contrast, the European Kidney Function Consortium (EKFC…
View article: Working towards a national End Stage Kidney Disease Data System for Ireland
Working towards a national End Stage Kidney Disease Data System for Ireland Open
Aims/Objectives This project proposed a framework to develop a national End Stage Kidney Disease (ESKD) data system in Ireland by exploring the core needs and design features from a diverse set of stakeholders. The objectives were to assim…
View article: Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol
Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol Open
Background Multimorbidity, defined as the coexistence of two or more chronic health conditions in affected individuals, is recognised as a significant global public health concern.. While previous research has identified common multimorbid…
View article: Prevalence and determinants of chronic kidney disease among community-dwelling adults, 50 years and older in Ireland
Prevalence and determinants of chronic kidney disease among community-dwelling adults, 50 years and older in Ireland Open
Background Using the Irish Longitudinal Study on Ageing (TILDA), we evaluated the prevalence and distribution of chronic kidney disease (CKD), and its determinants in order to identify risk groups for population health planning in Ireland.…
View article: Impact of Adoption of European Kidney Consortium Equation (EKFC) on CKD Prevalence and CKD Staging in Older Irish Adults
Impact of Adoption of European Kidney Consortium Equation (EKFC) on CKD Prevalence and CKD Staging in Older Irish Adults Open
Background The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation tends to overestimate glomerular filtration rate (GFR) and has limitation in younger and older age groups, while the European Kidney Function Consortium (E…
View article: Prevalence, awareness, treatment, and control of hypertension in community-dwelling older adults with chronic kidney disease: the Irish longitudinal study on ageing
Prevalence, awareness, treatment, and control of hypertension in community-dwelling older adults with chronic kidney disease: the Irish longitudinal study on ageing Open
Background Hypertension is highly prevalent in chronic kidney disease (CKD), posing a significant but modifiable risk for adverse clinical outcomes. This study explored the prevalence, awareness, treatment, and control of hypertension in o…
View article: #2449 Prevalence and determinants of chronic kidney disease among older community-dwelling adults in Ireland
#2449 Prevalence and determinants of chronic kidney disease among older community-dwelling adults in Ireland Open
Background and Aims Chronic Kidney Disease (CKD) is a major global health challenge with substantial morbidity and mortality. In Ireland, a comprehensive understanding of the determinants of CKD is lacking, with limited data on the combine…
View article: Combination Treatment with Verinurad and Allopurinol in CKD
Combination Treatment with Verinurad and Allopurinol in CKD Open
Key Points The SAPPHIRE trial was designed to assess albuminuria-lowering effects of the urate transporter 1 inhibitor verinurad combined with allopurinol in patients with CKD. Verinurad 3, 7.5, and 12 mg in combination with allopurinol 30…
View article: Prevalence of anaemia, iron, and vitamin deficiencies in the health system in the Republic of Ireland: a retrospective cohort study
Prevalence of anaemia, iron, and vitamin deficiencies in the health system in the Republic of Ireland: a retrospective cohort study Open
Background Anaemia is a common but treatable condition that predicts adverse clinical outcomes. However, standards of anaemia management vary considerably. Aim To estimate the prevalence of anaemia and extent of screening for common underl…
View article: Impact of serum sodium concentrations, and effect modifiers on mortality in the Irish Health System
Impact of serum sodium concentrations, and effect modifiers on mortality in the Irish Health System Open
Background Abnormalities of serum sodium are associated with increased mortality risk in hospitalised patients, but it is unclear whether, and to what extent other factors influence this relationship. We investigated the impact of dysnatra…
View article: Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function
Ferric Carboxymaltose in Iron-Deficient Patients with Hospitalized Heart Failure and Reduced Kidney Function Open
Background Reduced kidney function is common among patients with heart failure. In patients with heart failure and/or kidney disease, iron deficiency is an independent predictor of adverse outcomes. In the AFFIRM-AHF trial, patients with a…
View article: #6749 PREVALENCE, AWARENESS, TREATMENT, AND CONTROL OF HYPERTENSION IN OLDER ADULTS WITH CHRONIC KIDNEY DISEASE: THE IRISH LONGITUDINAL STUDY ON AGEING
#6749 PREVALENCE, AWARENESS, TREATMENT, AND CONTROL OF HYPERTENSION IN OLDER ADULTS WITH CHRONIC KIDNEY DISEASE: THE IRISH LONGITUDINAL STUDY ON AGEING Open
Background and Aims Hypertension is a well-known modifiable risk factor for chronic kidney disease (CKD) yet effective management remains a challenge. Data on hypertension awareness, treatment and control among CKD patients in Ireland is l…
View article: MO506: Disparities in Hospitalisation Rates Between Men and Women With and Without Chronic Kidney Disease in the Irish Health System
MO506: Disparities in Hospitalisation Rates Between Men and Women With and Without Chronic Kidney Disease in the Irish Health System Open
BACKGROUND AND AIMS It is increasingly recognized that disparities in health care utilisation and associated clinical outcomes exist between men and women. Whether these sex disparities extend to patients with chronic kidney disease (CKD) …
View article: Differential Impact of Central Venous Catheters versus Arteriovenous Fistulae on Quality of Life among Irish Haemodialysis Patients
Differential Impact of Central Venous Catheters versus Arteriovenous Fistulae on Quality of Life among Irish Haemodialysis Patients Open
Key Points The study compares the effect of vascular access (arteriovenous fistula versus central venous catheter) on health-related quality of life. Arteriovenous fistula users were more satisfied with their access but dissatisfied with p…
View article: Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia
Rationale, design, demographics and baseline characteristics of the randomized, controlled, Phase 2b SAPPHIRE study of verinurad plus allopurinol in patients with chronic kidney disease and hyperuricaemia Open
Background Verinurad is a human uric acid (UA) transporter (URAT1) inhibitor known to decrease serum UA (sUA) levels and that may reduce albuminuria. In a Phase 2a study (NCT03118739), treatment with verinurad + febuxostat lowered urine al…
View article: Iron Deficiency in CKD Without Concomitant Anemia
Iron Deficiency in CKD Without Concomitant Anemia Open
The physiological role of iron extends well beyond hematopoiesis. Likewise, the pathophysiological effects of iron deficiency (ID) extend beyond anemia. Although inextricably interrelated, ID and anemia of chronic kidney disease (CKD) are …
View article: Evolution of Vascular Access Use among Incident Patients during the First Year on Hemodialysis: A National Cohort Study
Evolution of Vascular Access Use among Incident Patients during the First Year on Hemodialysis: A National Cohort Study Open
Background Although the arteriovenous fistula (AVF) confers superior benefits over central venous catheters (CVCs), utilization rates remain low among prevalent patients on hemodialysis (HD). The goal of this study was to determine the evo…
View article: Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study
Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study Open
Context Combining a sodium-glucose cotransporter 2 inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowering. However, concerns exist regarding high urinary UA …
View article: Exploring reasons for state-level variation in incidence of dialysis-requiring acute kidney injury (AKI-D) in the United States
Exploring reasons for state-level variation in incidence of dialysis-requiring acute kidney injury (AKI-D) in the United States Open
Background There is considerable state-level variation in the incidence of dialysis-requiring acute kidney injury (AKI-D). However, little is known about reasons for this geographic variation. Methods National cross-sectional state-level e…
View article: Propensity score matched mortality comparisons of peritoneal and in-centre haemodialysis: systematic review and meta-analysis
Propensity score matched mortality comparisons of peritoneal and in-centre haemodialysis: systematic review and meta-analysis Open
Background Accurate comparisons of haemodialysis (HD) and peritoneal dialysis (PD) survival based on observational studies are difficult due to substantial residual confounding that arises from imbalances between treatments. Propensity sco…
View article: Failure to reach uric acid target of <0.36 mmol/L in hyperuricaemia of gout is associated with elevated total and cardiovascular mortality
Failure to reach uric acid target of <0.36 mmol/L in hyperuricaemia of gout is associated with elevated total and cardiovascular mortality Open
Objective To determine the impact of achieving serum uric acid (sUA) of <0.36 mmol/L on overall and cardiovascular (CV) mortality in patients with gout. Methods Prospective cohort of patients with gout recruited from 1992 to 2017. Exposure…
View article: Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study
Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study Open
Objective Evaluate the association between gout and risk of advanced chronic kidney disease (CKD). Design Retrospective matched cohort study. Setting UK Clinical Practice Research Datalink. Participants The analysis included data for 68 89…