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View article: Supplemental figures from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Supplemental figures from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity Open
Supplemental figures 1-19 with figure legends
View article: Supplemental figures from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Supplemental figures from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity Open
Supplemental figures 1-19 with figure legends
View article: Data from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Data from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity Open
Purpose:There is a need for strategies to prevent prostate cancer. Cholesterol-lowering interventions are employed widely and safely to reduce risk of cardiovascular disease and has been proposed for chemoprevention. Using preclinical mode…
View article: Data from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Data from Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity Open
Purpose:There is a need for strategies to prevent prostate cancer. Cholesterol-lowering interventions are employed widely and safely to reduce risk of cardiovascular disease and has been proposed for chemoprevention. Using preclinical mode…
View article: Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling Open
Prostate cancer (PC) is the most commonly diagnosed cancer in men and is the second leading cause of male cancer-related death in North America. Metabolic adaptations in malignant PC cells play a key role in fueling the growth and progress…
View article: Exposure to C. Albicans Makes Bladder Epithelial Cells Induce Apoptosis and Modification of Their Microenvironment
Exposure to C. Albicans Makes Bladder Epithelial Cells Induce Apoptosis and Modification of Their Microenvironment Open
INTRODUCTION. Interstitial cystitis/painful bladder syndrome (IC) is characterized by chronic bladder pain and urinary storage symptoms. IC affects more than 3.3 million women in the U.S. alone. Ibis T-5000 assays and next generation seque…
View article: Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity
Cholesterol-Lowering Intervention Decreases mTOR Complex 2 Signaling and Enhances Antitumor Immunity Open
Purpose: There is a need for strategies to prevent prostate cancer. Cholesterol-lowering interventions are employed widely and safely to reduce risk of cardiovascular disease and has been proposed for chemoprevention. Using preclinical mod…
View article: Lipid Raft Microdomains of Bladder Epithelial Cells Regulates Apoptosis and Microenvironment Upon Exposure to C. albicans
Lipid Raft Microdomains of Bladder Epithelial Cells Regulates Apoptosis and Microenvironment Upon Exposure to C. albicans Open
INTRODUCTION. Interstitial cystitis/painful bladder syndrome (IC) is characterized by chronic bladder pain and urinary storage symptoms. IC affects more than 3.3 million women in the U.S. alone. Ibis T-5000 assays and next generation seque…
View article: MP33-07 SERUM CHOLESTEROL-LOWERING IN A PROSTATE CANCER MODEL ENHANCES ANTITUMOR IMMUNITY BY DECREASING MTOR2 SIGNALING IN CD8+ LYMPHOCYTES
MP33-07 SERUM CHOLESTEROL-LOWERING IN A PROSTATE CANCER MODEL ENHANCES ANTITUMOR IMMUNITY BY DECREASING MTOR2 SIGNALING IN CD8+ LYMPHOCYTES Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I (MP33)1 Sep 2021MP33-07 SERUM CHOLESTEROL-LOWERING IN A PROSTATE CANCER MODEL ENHANCES ANTITUMOR IMMUNITY BY DECREASING MTOR2 SIGNALING IN CD8+ LYMPHOCYTE…
View article: Cholesterol-lowering Decreased mTOR Complex 2 Signaling and Enhanced Antitumor Immunity
Cholesterol-lowering Decreased mTOR Complex 2 Signaling and Enhanced Antitumor Immunity Open
Summary Cholesterol-lowering interventions are employed widely and safely to reduce risk of cardiovascular disease. Cholesterol may have complex and opposing effects on immunity. We lowered serum cholesterol to clinically relevant levels i…
View article: Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology
Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology Open
Objectives: Bisphosphonates (BPs) are powerful inhibitors of osteoclastogenesis and are used to prevent osteoporotic bone loss and reduce the risk of osteoporotic fracture in patients suffering from postmenopausal osteoporosis. Patients wi…
View article: Stress-Induced Accumulation of HnRNP K into Stress Granules
Stress-Induced Accumulation of HnRNP K into Stress Granules Open
Stress granules (SGs) are cytoplasmic aggregates to reprogram gene expression in response to cellular stimulus. Here, we show that while SGs are being assembled in response to clotrimazole, an antifungal medication heterogeneous nuclear ri…
View article: Metabolomic and lipidomic approaches to identify biomarkers for bladder cancer and interstitial cystitis (Review)
Metabolomic and lipidomic approaches to identify biomarkers for bladder cancer and interstitial cystitis (Review) Open
The discovery, introduction and clinical use of prognostic and diagnostic biomarkers has significantly improved outcomes for patients with various illnesses, including bladder cancer (BC) and other bladder‑related diseases, such as benign …
View article: MP37-09 CHOLESTEROL LOWERING THERAPY PRIOR TO PROSTATECTOMY LOWERS PROLIFERATION RATES IN NORMAL GLAND AND LOW-GRADE CANCER
MP37-09 CHOLESTEROL LOWERING THERAPY PRIOR TO PROSTATECTOMY LOWERS PROLIFERATION RATES IN NORMAL GLAND AND LOW-GRADE CANCER Open
You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) III (MP37)1 Apr 2020MP37-09 CHOLESTEROL LOWERING THERAPY PRIOR TO PROSTATECTOMY LOWERS PROLIFERATION RATES IN NORMAL GLAND AND LOW-GRADE CANCER Eric M. Lo*…
View article: Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects
Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects Open
Purpose: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have been contradictory results. …
View article: Downregulation of CENPF Remodels Prostate Cancer Cells and Alters Cellular Metabolism
Downregulation of CENPF Remodels Prostate Cancer Cells and Alters Cellular Metabolism Open
Metabolic alterations in prostate cancer (PC) are associated with progression and aggressiveness. However, the underlying mechanisms behind PC metabolic functions are unknown. The authors’ group recently reported on the important role of c…
View article: Effectiveness of a Tailored Colorectal Cancer Educational Seminar in Enhancing the Awareness, Knowledge, and Behavior of Korean Americans Living in the Los Angeles Koreatown Area
Effectiveness of a Tailored Colorectal Cancer Educational Seminar in Enhancing the Awareness, Knowledge, and Behavior of Korean Americans Living in the Los Angeles Koreatown Area Open
There is a significant gap in our knowledge and understanding of the contributing factors that may be leading to low CRC screening rates in Korean Americans. This study suggests that well-tailored educational seminars can overcome certain …
View article: Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling Open
Prostate cancer (PC) is the most commonly diagnosed cancer in men and is the second leading cause of male cancer-related death in North America. Metabolic adaptations in malignant PC cells play a key role in fueling the growth and progress…
View article: Language and Culture Appropriate Approaches Needed to Improve Health Education to Reduce Disparities among Korean American Immigrants Living in Los Angeles
Language and Culture Appropriate Approaches Needed to Improve Health Education to Reduce Disparities among Korean American Immigrants Living in Los Angeles Open
This study aimed to determine the disparities associated with health awareness and access to health education among Korean American residents living in the Los Angeles area. In particular, this research focused on gathering data on how Kor…
View article: Sex-associated differences in baseline urinary metabolites of healthy adults
Sex-associated differences in baseline urinary metabolites of healthy adults Open
The biological basis for gender variability among disease states is not well established. There have been many prior efforts attempting to identify the unique urine metabolomic profiles associated with specific diseases. However, there has…
View article: Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A
Alpha-oxoglutarate inhibits the proliferation of immortalized normal bladder epithelial cells via an epigenetic switch involving ARID1A Open
Interstitial cystitis (IC) is a chronic urinary tract disease that is characterized by unpleasant sensations, such as persistent pelvic pain, in the absence of infection or other identifiable causes. We previously performed comprehensive m…
View article: Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance
Reprogrammed lipid metabolism in bladder cancer with cisplatin resistance Open
Due to its tendency to recur and acquire chemoresistance quickly, bladder cancer (BC) remains to be an elusive and difficult disease. Patients with recurrent and chemoresistant BC have an extremely poor prognosis. One possible approach tha…
View article: Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling Open
Prostate cancer (PC) is the most commonly diagnosed cancer in men and is the second leading cause of male cancer-related death in North America. Metabolic adaptations in malignant PC cells play a key role in fueling the growth and progress…
View article: Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism Open
Alterations in DNA methylation are important epigenetic markers in bladder cancer (BC). These epigenome modifications may drive the mechanisms of aggressive chemo-resistant BC. Clinicopathological biomarkers that indicate chemotherapeutic …
View article: Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling
Centromere protein F (CENPF), a microtubule binding protein, modulates cancer metabolism by regulating pyruvate kinase M2 phosphorylation signaling Open
Prostate cancer (PC) is the most commonly diagnosed cancer in men and is the second leading cause of male cancer-related death in North America. Metabolic adaptations in malignant PC cells play a key role in fueling the growth and progress…