Auvro R. Mridha
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View article: The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice
The selective peroxisome proliferator–activated receptor‐delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice Open
Lipotoxicity associated with insulin resistance is central to nonalcoholic steatohepatitis (NASH) pathogenesis. To date, only weight loss fully reverses NASH pathology, but mixed peroxisome proliferator–activated receptor‐alpha/delta (PPAR…
View article: NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice Open
View article: Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice
Obeticholic acid improves adipose morphometry and inflammation and reduces steatosis in dietary but not metabolic obesity in mice Open
Objective Nonalcoholic steatohepatitis (NASH) is the outcome of interactions between overnutrition, energy metabolism, and adipose function. Obeticholic acid (OCA) improves steatosis in patients but for unknown reasons does not resolve NAS…
View article: Parallel 7: Liver Transplant Diseases and Perioperative Management
Parallel 7: Liver Transplant Diseases and Perioperative Management Open
black tea.The mean ALT noted in 657 individuals within 3 months of TE was 60.6 U/L.The average BMI was 25.7 kg/m 2 and weight was 71.7 kg.Average daily alcohol consumption was 5 g/day.The average liver stiffness for the 1155 individuals wa…
View article: Parallel 8: Novel Molecular Targets in NASH
Parallel 8: Novel Molecular Targets in NASH Open
may help refine post-LT HCC surveillance strategies and identify patients who would derive the most benefits from future post-LT adjuvant therapies.
View article: Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice
Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice Open
Objective Adipose inflammation and dysfunction underlie metabolic obesity. Exercise improves glycemic control and metabolic indices, but effects on adipose function and inflammation are less clear. Accordingly, it was hypothesized that exe…