Ava Y Xu
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Author Swipe
View article: Tuberculosis disease severity assessment using clinical variables and radiology enabled by artificial intelligence
Tuberculosis disease severity assessment using clinical variables and radiology enabled by artificial intelligence Open
Radiology can define tuberculosis (TB) severity and may guide duration of treatment, however the optimal radiological metric to use and which clinical variables to combine it with in the real-world is unclear. We systematically associated …
View article: Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial
Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial Open
Rationale: Optimizing pyrazinamide dosing is critical to improve treatment efficacy while minimizing toxicity during tuberculosis treatment. Study 31/AIDS Clinical Trials Group A5349 represents the largest phase 3 randomized control…
View article: Pharmacokinetic-Pharmacodynamic Evidence From a Phase 3 Trial to Support Flat-Dosing of Rifampicin for Tuberculosis
Pharmacokinetic-Pharmacodynamic Evidence From a Phase 3 Trial to Support Flat-Dosing of Rifampicin for Tuberculosis Open
Background The optimal dosing strategy for rifampicin in treating drug-susceptible tuberculosis (TB) is still highly debated. In the phase 3 clinical trial Study 31/ACTG 5349 (NCT02410772), all participants in the control regimen arm recei…
View article: Calculating Pharmacokinetic Areas
Calculating Pharmacokinetic Areas Open
Although it is recognized that pharmacokinetic processes follow exponential processes, area under the curve ( AUC ) estimations are frequently carried out using linear trapezoidal methods. This is justified based on the fact that most huma…