Avi Gluck
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View article: A virally encoded high resolution screen of cytomegalovirus host dependencies
A virally encoded high resolution screen of cytomegalovirus host dependencies Open
Genetic screens have transformed our ability to interrogate cellular factor requirements in infection, yet current approaches are limited in their sensitivity, biased towards early stages of infection and provide only simplistic phenotypic…
View article: Parsing the role of NSP1 in SARS-CoV-2 infection
Parsing the role of NSP1 in SARS-CoV-2 infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed…
View article: Parsing the role of NSP1 in SARS-CoV-2 infection
Parsing the role of NSP1 in SARS-CoV-2 infection Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 (COVID-19) pandemic. Despite its urgency, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis and i…
View article: SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis
SARS-CoV-2 utilizes a multipronged strategy to suppress host protein synthesis Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing coronavirus disease 19 (COVID-19) pandemic. Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis a…