Aviad Zick
YOU?
Author Swipe
View article: DNA Methylation-Based Deconvolution Study of Glioblastoma Heterogeneity and Cell Types Associated with Patient Survival
DNA Methylation-Based Deconvolution Study of Glioblastoma Heterogeneity and Cell Types Associated with Patient Survival Open
Background: IDH-wildtype glioblastoma (GBM) is an aggressive, heterogeneous brain tumor with limited treatment options. This study tries to improve our understanding of GBM by applying DNA methylation-based deconvolution to define its cell…
View article: DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival
DNA Methylation-Based Deconvolution Sheds Light on Glioblastoma Heterogeneity and Cell-Type Composition Associated with Patient Survival Open
Background IDH-wildtype glioblastoma (GBM) is an aggressive, heterogeneous brain tumor with limited treatment options. DNA methylation profiling allows detailed tumor characterization. This study applies methylation-based deconvolution to …
View article: Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial
Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial Open
Neratinib had meaningful activity in selected patients with EGFR exon 18-mutant NSCLC, including patients pretreated with ≥1 TKI. Diarrhea was generally low grade. Given the lack of effective treatments after EGFR TKI failure for NSCLC wit…
View article: Detection of antibody–drug conjugate-induced interstitial lung disease using circulating cell-free DNA
Detection of antibody–drug conjugate-induced interstitial lung disease using circulating cell-free DNA Open
This proof-of-concept study demonstrates that liquid biopsy can be developed as a valuable tool for detecting and monitoring ADC-related ILD. Its low cost and simplicity make it a potential alternative to current imaging methods, warrantin…
View article: Clinical and genetic characteristics of carriers of the TP53 c.541C > T, p.Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent
Clinical and genetic characteristics of carriers of the TP53 c.541C > T, p.Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent Open
TP53 pathogenic variants cause Li-Fraumeni syndrome (LFS), with some variants causing an attenuated phenotype. Herein, we describe the clinical phenotype and genetic characteristics of carriers of NM_000546.6 ( TP53 ): c.541C > T, (p.Arg18…
View article: 134P Characterizing sarcoma molecular landscape by nanopore adaptive sampling sequencing
134P Characterizing sarcoma molecular landscape by nanopore adaptive sampling sequencing Open
Pathological diagnosis of sarcoma is based on histopathological features and immunohistochemical staining, as well as fluorescence in situ hybridization (FISH), Sanger sequencing, massively parallel DNA sequencing, and methylation-based ar…
View article: Unleashing the power of anti-HER2 therapies in metastatic colorectal cancer: paving the way for a brighter future
Unleashing the power of anti-HER2 therapies in metastatic colorectal cancer: paving the way for a brighter future Open
Colorectal cancer (CRC) constitutes a significant portion of cancer-related deaths in the United States, topping cancer-related mortality among males under 50 years of age. Despite an increase in overall survival throughout the years, the …
View article: Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer
Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer Open
Objective Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed. Design To assess circulating mark…
View article: Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study
Short report: Plasma based biomarkers detect radiation induced brain injury in cancer patients treated for brain metastasis: A pilot study Open
Background Radiotherapy has an important role in the treatment of brain metastases but carries risk of short and/or long-term toxicity, termed radiation-induced brain injury (RBI). As the diagnosis of RBI is crucial for correct patient man…
View article: A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy
A clinical evaluation of an ex vivo organ culture system to predict patient response to cancer therapy Open
Introduction Ex vivo organ cultures (EVOC) were recently optimized to sustain cancer tissue for 5 days with its complete microenvironment. We examined the ability of an EVOC platform to predict patient response to cancer therapy. Methods A…
View article: Clinical Characteristics, Response to Platinum-Based Chemotherapy and Poly (Adenosine Phosphate-Ribose) Polymerase Inhibitors in Advanced Lung Cancer Patients Harboring BRCA Mutations
Clinical Characteristics, Response to Platinum-Based Chemotherapy and Poly (Adenosine Phosphate-Ribose) Polymerase Inhibitors in Advanced Lung Cancer Patients Harboring BRCA Mutations Open
The oncogenic role and clinical relevance of BRCA mutations in NSCLC remain unclear. We aim to evaluate the characteristics and clinical outcomes of patients with NSCLC harboring BRCA mutations treated at Hadassah Medical Center (HMC). We …
View article: First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report
First Female Patient with a Rare CIC-FOXO4-Translocated Sarcoma: A Case Report Open
Small round cell sarcoma is a group of undifferentiated malignancies arising in the bone and soft tissue, notable for Ewing sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subs…
View article: Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer
Oral Selinexor as Maintenance Therapy After First-Line Chemotherapy for Advanced or Recurrent Endometrial Cancer Open
PURPOSE Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity in endometrial cancer (EC). The primary end point was to assess progression-free survival (…
View article: Rapid Classification of Sarcomas Using Methylation Fingerprint: A Pilot Study
Rapid Classification of Sarcomas Using Methylation Fingerprint: A Pilot Study Open
Sarcoma classification is challenging and can lead to treatment delays. Previous studies used DNA aberrations and machine-learning classifiers based on methylation profiles for diagnosis. We aimed to classify sarcomas by analyzing methylat…
View article: Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel Open
Background Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and t…
View article: P.083 Liquid biopsies reveal brain cell death in central nervous system tumors
P.083 Liquid biopsies reveal brain cell death in central nervous system tumors Open
Background: Circulating cell-free DNA (cfDNA) is a novel type of biomarker with a broad utility in diagnostic medicine, based on the release of DNA fragments from dying cells to the circulation. We developed an approach for identifying the…
View article: Driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced non-small cell lung cancer
Driver mutation characteristics of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced non-small cell lung cancer Open
In a small minority of NSCLC patients with PIK3CA mutation there are no additional AGA. PIK3CA mutations may be actionable in these cases.
View article: Plasma based biomarkers detect radiation induced neurotoxicity in cancer patients treated for brain metastasis: A Pilot study.
Plasma based biomarkers detect radiation induced neurotoxicity in cancer patients treated for brain metastasis: A Pilot study. Open
Radiotherapy has an important role in the treatment of brain metastases (BrM) but carries risk of short and/or long-term toxicity, termed radiation-induced neurotoxicity (RIN). As the diagnosis of RIN is crucial for correct pa-tient manage…
View article: Supplementary Material for: First female patient with a rare CIC¬-FOXO4 translocated sarcoma – a case report
Supplementary Material for: First female patient with a rare CIC¬-FOXO4 translocated sarcoma – a case report Open
Small round cell sarcoma is a group of undifferentiated malignancies arising in bone and soft tissue, notable for Ewing Sarcoma. Recently, a new World Health Organization classification has been introduced, including an additional subset o…
View article: A universal cell‐free <scp>DNA</scp> approach for response prediction to preoperative chemoradiation in rectal cancer
A universal cell‐free <span>DNA</span> approach for response prediction to preoperative chemoradiation in rectal cancer Open
The standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. In recent years, new treatment approaches have led to higher rates of complete tumor eradication combined with…
View article: Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing Open
View article: Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes
Subtyping of Small Cell Lung Cancer using plasma cell-free nucleosomes Open
Emerging data on small cell lung cancer (SCLC), an aggressive malignancy with exceptionally poor prognosis, support subtypes driven by distinct transcription regulators, which engender unique therapeutic vulnerabilities. However, the trans…
View article: Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial
Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial Open
PURPOSE Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-…
View article: Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair
Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair Open
DNA repair by homologous recombination (HR) is critical for the maintenance of genome stability. Germline and somatic mutations in HR genes have been associated with an increased risk of developing breast (BC) and ovarian cancers (OvC). Ho…
View article: Potential Refinement of Recurrence Score by pSTAT3 Status
Potential Refinement of Recurrence Score by pSTAT3 Status Open
The likelihood of recurrence in breast cancer patients with hormone receptor-positive (HR-positive) tumors is influenced by clinical, histopathological, and molecular features. Recent studies suggested that activated STAT3 (pSTAT3) might s…
View article: Liquid biopsy reveals collateral tissue damage in cancer
Liquid biopsy reveals collateral tissue damage in cancer Open
Cancer inflicts damage to surrounding normal tissues, which can culminate in fatal organ failure. Here, we demonstrate that cell death in organs affected by cancer can be detected by tissue-specific methylation patterns of circulating cell…
View article: Additional file 3 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Additional file 3 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing Open
Additional file 3. Table S2. External WGBS sample information.
View article: Additional file 4 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Additional file 4 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing Open
Additional file 4. Table S3. Tumor vs. normal differences for 4-mer end motifs.
View article: Additional file 5 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Additional file 5 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing Open
Additional file 5. ichorCNA plots for all cfNano and matched Illumina WGS samples.
View article: Additional file 2 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing
Additional file 2 of Detecting cell-of-origin and cancer-specific methylation features of cell-free DNA from Nanopore sequencing Open
Additional file 2. Table S1. cfNano sample information and statistics.