Explanipedia

Validation of the Atopic Dermatitis Control Tool (ADCT) and a Comparison with the Recap of Atopic Eczema Questionnaire (RECAP) Open

Junfen Zhang, L. A. Miltner, Laura Loman, Aviël Ragamin, Jart A. F. Oosterhaven , et al. · 2025

The Atopic Dermatitis Control Tool (ADCT) has not been validated in the Dutch population, and comparisons with the Recap of atopic eczema (RECAP) questionnaire are still lacking. This prospective study was conducted at a Dutch tertiary hos…

Management Strategies and Corticophobia among Healthcare Professionals Involved in the Care for Atopic Dermatitis: A Dutch Survey Open

Aviël Ragamin, Karlijn F. van Halewijn, Renske Schappin, Willemijn C. A. M. Witkam, Nicolette J. T. Arends , et al. · 2024

Introduction: Various healthcare professionals (HCPs) deliver care for patients with atopic dermatitis (AD). Although pivotal, management strategies and the relation with corticophobia among HCPs have not been investigated. This study aime…

Developing a Core Outcome Set for Netherton Syndrome: An International Multi-Stakeholder e-Delphi Consensus Study Open

Anouk E. M. Nouwen, Aviël Ragamin, Mirjam J. Knol, Hagen Ott, Lisa Weibel , et al. · 2024

Introduction: Netherton syndrome (NS; OMIM#256500) is a rare and severe disorder of epidermal maturation and keratinization caused by pathogenic variants in the serine protease inhibitor Kazal type 5 (SPINK5), leading to severe skin barrie…

Does experience matter when assessing the eczema area and severity index? Open

Aviël Ragamin, Renske Schappin, Suzanne G.M.A. Pasmans, Marie L. A. Schuttelaar · 2024

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Shared symptomatology between atopic dermatitis, ADHD and autism spectrum disorder: a protocol for a systematic scoping review Open

Ngoc Tan Nguyen, Aviël Ragamin, André B. Rietman, Tamar Nijsten, Renske Schappin · 2024

Introduction Children with atopic dermatitis (AD) are more at risk for the neurodevelopmental disorders attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) with parallel increases in global prevalences. Child…

The construct validity, responsiveness, reliability and interpretability of the Recap of atopic eczema questionnaire (RECAP) in children Open

Aviël Ragamin, Junfen Zhang, Suzanne G.M.A. Pasmans, Renske Schappin, Geertruida L. E. Romeijn , et al. · 2024

Background The Recap of atopic eczema questionnaire (RECAP) was developed to measure eczema control in patients with atopic dermatitis (AD). The measurement properties of RECAP have not yet been validated in caregivers of children with AD.…

Effectiveness of antibacterial therapeutic clothing vs. nonantibacterial therapeutic clothing in patients with moderate-to-severe atopic dermatitis: a randomized controlled observer-blind pragmatic trial (ABC trial) Open

Aviël Ragamin, Renske Schappin, Marlies de Graaf, Ron A. Tupker, Karin B. Fieten , et al. · 2023

Background Increased Staphylococcus aureus (SA) colonization is considered an important factor in the pathogenesis of atopic dermatitis (AD). Antibacterial therapeutic clothing aims to reduce SA colonization and AD inflammation; however, i…

Therapeutic Clothing Use in Atopic Dermatitis in the Netherlands: A Population Based Cohort Study Open

Aviël Ragamin, Renske Schappin, Suzanne G.M.A. Pasmans, Marie L. A. Schuttelaar · 2023

National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of therapeutic clothing in atopic dermatitis. Therapeutic clothing is most frequently prescribed by dermatologists in a hospital …

Prognostic Factors for Long-term Aesthetic Outcome of Infantile Haemangioma Treated with Beta-blockers Open

Mireille M. Hermans, Suzanne G.M.A. Pasmans, Marlies de Graaf, Aviël Ragamin, Elodie J. Mendels , et al. · 2023

Parents of infants treated with beta-blockers for infantile haemangioma are often concerned about the long-term aesthetic outcome. This cross-sectional study assessed the influence on the long-term aesthetic outcome of characteristics of t…

Remote severity assessment in atopic dermatitis: Validity and reliability of the remote Eczema Area and Severity Index and Self-Administered Eczema Area and Severity Index Open

Aviël Ragamin, Renske Schappin, N. Tan Nguyen, Anouk E. M. Nouwen, Lisanne F. Hoekstra , et al. · 2023

Perceived adherence and associated barriers to the national atopic dermatitis guideline: A survey among general practitioners Open

Aviël Ragamin, Karlijn F. van Halewijn, Marie L. A. Schuttelaar, Marjolein Lugtenberg, Suzanne G.M.A. Pasmans , et al. · 2023

General practitioners (GPs) have an important role in managing patients with atopic dermatitis (AD). Although pivotal, adherence to dermatological guidelines in general practice has not been assessed. To assess GPs’ perceived adherence and…

Validity, reliability, responsiveness and interpretability of the Recap of atopic eczema (RECAP) questionnaire Open

Junfen Zhang, Aviël Ragamin, Geertruida L. E. Romeijn, Laura Loman, Jart A. F. Oosterhaven , et al. · 2023

Background Limited research has been conducted on the measurement properties of the Recap of atopic eczema (RECAP) questionnaire, particularly in relation to interpretability. Objectives To investigate the validity, reliability, responsive…

Investigator Global Assessment for impetiginization in atopic dermatitis: development and initial reliability testing Open

Aviël Ragamin, Ron A. Tupker, Marlies de Graaf, Thomas Rustemeyer, Suzanne G.M.A. Pasmans , et al. · 2023

Secondary infections with Staphylococcus aureus (i.e. impetiginization) are common in patients with atopic dermatitis (AD). However, a scale to assess the severity of impetiginization is lacking. This study aimed to develop and investigate…

Treatment Experiences with Intravenous Immunoglobulins, Ixekizumab, Dupilumab, and Anakinra in Netherton Syndrome: A Case Series Open

Aviël Ragamin, Anouk E. M. Nouwen, Virgil A. S. H. Dalm, Minke M.F. van Mierlo, Carsten R. Lincke , et al. · 2022

Background: Netherton syndrome (NS) is a rare potential life-threatening disorder that causes severe defects to the skin barrier. No effective treatment options are available for patients with NS and current therapy is mostly supportive. T…

Validity and Reliability of Two Digital Wound Measurement Tools after Surgery in Patients with Hidradenitis Suppurativa Open

Pim Aarts, Johanna C. van Huijstee, Aviël Ragamin, Joanne L. Reeves, Catherine van Montfrans , et al. · 2022

Background: After excision surgery in patients with hidradenitis suppurativa (HS), wounds are usually left open for secondary intention healing. To evaluate wound healing, reliable wound measurement is important. However, digital wound mea…

Long Term Effects of Digital Education among Healthcare Professionals in Paediatric Dermatology: Opportunities for Improving Care Open

Aviël Ragamin, Renske Schappin, Willemijn C. A. M. Witkam, Magda Spiering, Elodie J. Mendels , et al. · 2022

Background Topical corticosteroids (TCS) are the cornerstone of treatment for patients with atopic dermatitis (AD). Unfortunately, anxiety and misplaced beliefs on TCS, known as corticophobia, is common among health care professionals (HCP…

Content validity of the Recap of atopic eczema (RECAP) instrument in Dutch, English and German to measure eczema control in young people with atopic eczema: a cognitive interview study Open

Michaela Gabes, Aviël Ragamin, Arabella Baker, Gesina Kann, Theresa Donhauser , et al. · 2022

Background Recap of atopic eczema (RECAP) is a patient-reported outcome measure assessing eczema control. This instrument has been developed and validated in the UK. There are self-reported and proxy-reported versions in English, Dutch and…

Aesthetic Outcome of Propranolol vs Atenolol Treatment of Children with Infantile Haemangioma Open

Mireille M. Hermans, Corstiaan C. Breugem, Renske Schappin, Emma Jonge Poerink, Elodie J. Mendels , et al. · 2022

Infantile haemangiomas are common benign tumours of infancy, which can be treated effectively with beta-blockers such as propranolol and atenolol. Different types of beta-blockers may result in different long-term aesthetic outcomes. This …

Outcomes of Systemic Treatment in Children and Adults With Netherton Syndrome: A Systematic Review Open

Anouk E. M. Nouwen, Renske Schappin, N. Tan Nguyen, Aviël Ragamin, Anette Bygum , et al. · 2022

Background Comèl-Netherton syndrome (NS) is a rare disease caused by pathogenic variants in the SPINK5 gene, leading to severe skin barrier impairment and proinflammatory upregulation. Given the severity of the disease, treatment of NS is …

Supplementary Material for: Validity and Reliability of Two Digital Wound Measurement Tools after Surgery in Patients with Hidradenitis Suppurativa Open

Pim Aarts, vanHuijstee J.C., Aviël Ragamin, Reeves J.L., C. vanMontfrans , et al. · 2022

Background: After excision surgery in patients with hidradenitis suppurativa (HS), wounds are usually left open for secondary intention healing. To evaluate wound healing, reliable wound measurement is important. However, dig…

Supplementary Material for: Treatment Experiences with Intravenous Immunoglobulins, Ixekizumab, Dupilumab, and Anakinra in Netherton Syndrome: A Case Series Open

Aviël Ragamin, Nouwen A.E.M., Dalm V.A.S.H., vanMierlo M.M.F., Lincke C.R. , et al. · 2022

Background: Netherton syndrome (NS) is a rare potential life-threatening disorder that causes severe defects to the skin barrier. No effective treatment options are available for patients with NS and current therapy is mostly…

The effectiveness of antibacterial therapeutic clothing based on silver or chitosan as compared with non-antibacterial therapeutic clothing in patients with moderate to severe atopic dermatitis (ABC trial): study protocol for a pragmatic randomized controlled trial Open

Aviël Ragamin, Karin B. Fieten, Ron A. Tupker, Jill de Wit, Minke M.F. van Mierlo , et al. · 2021

Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10 to 20% of children and between 2 and 15% of the adults in Western Europe. Since 2000, therapeutic clothing or functional textiles based on silver or c…

Care for children with atopic dermatitis in the Netherlands during the COVID‐19 pandemic: Lessons from the first wave and implications for the future Open

Aviël Ragamin, Linde E. M. de Wijs, DirkJan Hijnen, Nicolette J. T. Arends, Marie L. A. Schuttelaar , et al. · 2021

The first wave of the coronavirus disease 2019 (COVID‐19) pandemic had an enormous impact on health‐care services, including on care provision for children with atopic dermatitis (AD). We investigated the impact of COVID‐19 on the care for…

The Effectiveness Of Antibacterial Therapeutic Clothing Based On Silver Or Chitosan As Compared With Non-Antibacterial Therapeutic Clothing In Patients With Moderate To Severe Atopic Dermatitis (ABC Trial): Study Protocol For A Pragmatic Randomized Controlled Trial Open

Aviël Ragamin, Karin B. Fieten, Ron A. Tupker, Jill de Wit, Minke M.F. van Mierlo , et al. · 2021

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 10% to 20% of children and between 2% and 15% of the adults in Western Europe. Since 2000 therapeutic clothing or functional textiles based on silver or…

De novo TRPV4 Leu619Pro variant causes a new channelopathy characterised by giant cell lesions of the jaws and skull, skeletal abnormalities and polyneuropathy Open

Aviël Ragamin, Carolina Cavaliéri Gomes, Karen Bindels‐de Heus, Renata Lazari Sandoval, Angelia V. Bassenden , et al. · 2021

Background Pathogenic germline variants in T ransient R eceptor P otential V anilloid 4 C ation C hannel ( TRPV4 ) lead to channelopathies, which are phenotypically diverse and heterogeneous disorders grossly divided in neuromuscular disor…

Outcome assessment in dermatology: a tree in need of pruning Open

Aviël Ragamin, Tamar Nijsten · 2021

Linked article: T. Lange et al. J Eur Acad Dermatol Venereol 2021; 35: 523–535. https://doi.org/10.1111/jdv.16854 .

Human RAD50 deficiency: Confirmation of a distinctive phenotype Open

Aviël Ragamin, Gökhan Yiğit, Kristine Bousset, Filippo Beleggia, Frans W. Verheijen , et al. · 2020

DNA double‐strand breaks (DSBs) are highly toxic DNA lesions that can lead to chromosomal instability, loss of genes and cancer. The MRE11/RAD50/NBN (MRN) complex is keystone involved in signaling processes inducing the repair of DSB by, f…

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