Avinash Bansode
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View article: PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys
PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys Open
Background Older vervet monkeys are an excellent model for studying age‐associated Aß deposition; however, they have high proportions of low‐affinity Aß sites compared to human brains. Commonly used Aß PET radiotracers are most useful in d…
View article: PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys
PET imaging utility of a novel Aβ‐tracking PET radiotracer, [<sup>18</sup>F]FC119S in aged vervet monkeys Open
Background Older vervet monkeys are an excellent model for studying age‐associated Aβ deposition; however, they have high proportions of low‐affinity Aβ sites compared to human brains. Commonly used Aβ PET radiotracers are most useful in d…
View article: Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology
Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [<sup>11</sup>C]MPC‐6827 PET imaging in rodent models of Alzheimer's‐related pathology Open
INTRODUCTION Microtubule (MT) stability is crucial for proper neuronal function. Understanding MT dysregulation is critical for connecting amyloid beta (Aβ) and tau‐based degenerative events and early changes in presymptomatic Alzheimer's …
View article: Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease
Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease Open
Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo levels in the same brain. Any therapeutic intervention relying on MT destabilization …
View article: Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease
Dual PET imaging of microtubules and synaptic density in a mouse model of Alzheimer’s Disease Open
Background While microtubule (MT)‐destabilization and synaptic loss hallmark AD pathological events, no study has systematically quantified their in vivo levels in the same brain. Any therapeutic intervention relying on MT destabilization …
View article: Preliminary PET Imaging of Microtubule-Based PET Radioligand [<sup>11</sup>C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease
Preliminary PET Imaging of Microtubule-Based PET Radioligand [<sup>11</sup>C]MPC-6827 in a Nonhuman Primate Model of Alzheimer’s Disease Open
The microtubule (MT) instability observed in Alzheimer's disease (AD) is commonly attributed to hyperphosphorylation of the MT-associated protein, tau. In vivo PET imaging offers an opportunity to gain critical information about MT changes…
View article: First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations
First GPR119 PET Imaging Ligand: Synthesis, Radiochemistry, and Preliminary Evaluations Open
G-protein-coupled receptor 119 (GPR119) has emerged as a promising target for treating type 2 diabetes mellitus. Activating GPR119 improves glucose homeostasis, while suppressing appetite and weight gain. Measuring GPR119 levels in vivo co…
View article: Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates
Preliminary biological evaluations of first brain‐penetrant GPR119‐based radiotracer in rodents and non‐human primates Open
Background G‐protein‐coupled receptors (GPCRs) plays a key role in regulating glucose metabolism. While GPR119 (an important GPCR) agonists have shown potential for improving neurologic and cognitive function in patients with AD and type2 …
View article: Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents
Binding Parameters of [11C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents Open
Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological dis…
View article: [18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates
[18F]KS1, a novel ascorbate-based ligand images ROS in tumor models of rodents and nonhuman primates Open
Over production of reactive oxygen species (ROS) caused by altered redox regulation of signaling pathways is common in many types of cancers. While PET imaging is recognized as the standard tool for cancer imaging, there are no clinically-…
View article: Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model
Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model Open
Background Microtubules (MTs) are critical for cell structure, function, and survival. MT instability may contribute to Alzheimer’s disease (AD) pathogenesis as evidenced by persistent negative regulation (phosphorylation) of the neuronal …
View article: Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse
Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse Open
Purpose Microtubules (MTs) are structural units made of α and β tubulin subunits in the cytoskeleton responsible for axonal transport, information processing, and signaling mechanisms—critical for healthy brain function. Chronic cocaine ex…
View article: Initial biological evaluation of a novel microtubule‐based PET ligand in rodent and NHP models of AD
Initial biological evaluation of a novel microtubule‐based PET ligand in rodent and NHP models of AD Open
Background Microtubule (MT) integrity is critical for cell function and viability. Abnormal MT stability is commonly attributed to hyperphosphorylation of the MT‐associated protein, tau. However, the time course of MT instability in diseas…
View article: Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells
Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells Open
Microtubules (MTs) are structural units in the cytoskeleton. In brain cells they are responsible for axonal transport, information processing, and signaling mechanisms. Proper function of these processes is critical for healthy brain funct…
View article: Ethanol and cocaine increases microtubule stability and decreases [11C]MPC-6827 uptake in SH-SY5Y cells
Ethanol and cocaine increases microtubule stability and decreases [11C]MPC-6827 uptake in SH-SY5Y cells Open
Microtubules (MTs) are structural units in the cytoskeleton. In brain cells they are responsible for axonal transport, information processing, and signaling mechanisms. Proper function of these processes is critical for healthy brain funct…