Avinash Chettri
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View article: Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters
Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters Open
This work describes the first polymeric photoacids based on poly(2‐oxazoline)s. The presence of 1‐hydroxypyrene units—a photoacid that can increase its acidity upon blue light irradiation through excited‐state proton transfer—allows remote…
Ultrafast light-switch properties of a G-quadruplex binder: [Ru(phen) <sub>2</sub> (tpphz-DC3)] <sup>4+</sup> Open
The ultrafast photophysics of a G-quadruplex binding light-switch, [Ru(phen) 2 (tpphz-DC3)] 4+ , is explored. Distinctions in photophysics with DNA topology are observed between [Ru(phen) 2 (dppz)] 2+ and [Ru(phen) 2 (tpphz-DC3)] 4+ .
Poly(2‐Oxazoline) Amphiphilicity Tunes the Excited‐State Proton Transfer of Pyrenol‐Based Polyphotoacids Open
The ability of light to change the properties of light‐responsive polymers opens avenues for targeted release of cargo with a high degree of spatial and temporal control. Recently, we established photoacid polymers as light‐switchable macr…
An Iridium Complex as Bidentate Halogen Bond‐Based Anion Receptor Featuring an IncreasedOptical Response Open
We present a luminescent Ir(III) complex featuring a bidentate halogen bond donor site capable of strong anion binding. The tailor‐made Ir(III)(L) 2 moiety offers a significantly higher emission quantum yield (8.4 %) compared to previous I…
Using Biological Photophysics to Map the Excited‐State Topology of Molecular Photosensitizers for Photodynamic Therapy Open
This study employs TLD1433, a Ru II ‐based photodynamic therapy (PDT) agent in human clinical trials, as a benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) in cellulo , in the local environ…
Using Biological Photophysics to Map the Excited‐State Topology of Molecular Photosensitizers for Photodynamic Therapy Open
This study employs TLD1433, a Ru II ‐based photodynamic therapy (PDT) agent in human clinical trials, as a benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) in cellulo , in the local environ…
In Cellulo Light‐Induced Dynamics in a BODIPY‐Perylene Dyad Open
BODIPY‐based donor‐acceptor dyads are widely used as sensors and probes in life science. Thus, their biophysical properties are well established in solution, while their photophysical properties in cellulo , i. e., in the environment, in w…
View article: Excited‐State Dynamics in Borylated Arylisoquinoline Complexes in Solution and <i>in cellulo</i>
Excited‐State Dynamics in Borylated Arylisoquinoline Complexes in Solution and <i>in cellulo</i> Open
Two four‐coordinate organoboron N , C ‐chelate complexes with different functional terminals on the PEG chains are studied with respect to their photophysical properties within human MCF‐7 cells. Their excited‐state properties are characte…
Interaction with a Biomolecule Facilitates the Formation of the Function-Determining Long-Lived Triplet State in a Ruthenium Complex for Photodynamic Therapy Open
TLD1433 is the first ruthenium (Ru)-based photodynamic therapy (PDT) agent to advance to clinical trials and is currently in a phase II study for treating nonmuscle bladder cancer with PDT. Herein, we present a photophysical study of TLD14…
A Molecular Photosensitizer in a Porous Block Copolymer Matrix‐Implications for the Design of Photocatalytically Active Membranes Open
Recently, porous photocatalytically active block copolymer membranes were introduced, based on heterogenized molecular catalysts. Here, we report the integration of the photosensitizer, i. e., the light absorbing unit in an intermolecular …
Switching the Mechanism of NADH Photooxidation by Supramolecular Interactions Open
A series of three Ru(II) polypyridine complexes was investigated for the selective photocatalytic oxidation of NAD(P)H to NAD(P) + in water. A combination of (time‐resolved) spectroscopic studies and photocatalysis experiments revealed tha…
String-Attached Oligothiophene Substituents Determine the Fate of Excited States in Ruthenium Complexes for Photodynamic Therapy Open
We explore the photophysical properties of a family of Ru(II) complexes, Ru-ip-nT, designed as photosensitizers (PSs) for photodynamic therapy (PDT). The complexes incorporate a 1H-imidazo[4,5-f][1,10]-phenanthroline (ip) ligand appended t…
Monitoring excited-state relaxation in a molecular marker in live cells–a case study on astaxanthin Open
Small molecules are frequently used as dyes, labels and markers to visualize and probe biophysical processes within cells. However, very little is generally known about the light-driven excited-state reactivity of such systems when placed …
It Takes Three to Tango: The Length of the Oligothiophene Chain Determines the Nature of the Long‐Lived Excited State and the Resulting Photocytotoxicity of a Ruthenium(II) Photodrug Open
TLD1433 is the first Ru(II) complex to be tested as a photodynamic therapy agent in a clinical trial. In this contribution we study TLD1433 in the context of structurally‐related Ru(II)‐imidozo[4,5‐f][1,10]phenanthroline (ip) complexes app…
Monitoring excited-state relaxation in a molecular marker in live cells–a case study on astaxanthin Open
Small molecules are frequently used as dyes, labels and markers to visualize and probe biophysical processes within cells.
Intracellular Photophysics of an Osmium Complex bearing an Oligothiophene Extended Ligand Open
This contribution describes the excited‐state properties of an Osmium‐complex when taken up into human cells. The complex 1 [Os(bpy) 2 (IP‐4T)](PF 6 ) 2 with bpy=2,2′‐bipyridine and IP‐4T=2‐{5′‐[3′,4′‐diethyl‐(2,2′‐bithien‐5‐yl)]‐3,4‐dieth…