Avinash G. Dinmohamed
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View article: COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study
COVID-19 Vaccine Effectiveness in Patients With Hematologic Malignancies: A Nationwide Cohort Study Open
Background In patients with hematologic malignancies, COVID-19 vaccine effectiveness is unknown and determinants of severe COVID-19 lack granularity. Methods To identify determinants of SARS-CoV-2 infection outcome we conducted a populatio…
View article: Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets
Clonal haematopoiesis associates with distinct cytometric changes of red blood cells and platelets Open
Summary Individuals with macrocytosis or a high RDW are at increased risk of developing haematological malignancies. The mechanisms that mediate this association remain unknown but may involve the presence of clonal haematopoiesis (CH). He…
View article: Real-time data in cancer registries: Validation of an automated data extraction system
Real-time data in cancer registries: Validation of an automated data extraction system Open
View article: 41 | PROSPECTIVE VALIDATION OF END OF TREATMENT ctDNA‐MRD BY PhasED‐Seq IN DLBCL PATIENTS FROM A NATIONAL HOVON TRIAL
41 | PROSPECTIVE VALIDATION OF END OF TREATMENT ctDNA‐MRD BY PhasED‐Seq IN DLBCL PATIENTS FROM A NATIONAL HOVON TRIAL Open
View article: Comparability of external and internal control patients for the prospective randomized <scp>HOVON</scp>‐103 trial in older <scp>AML</scp> patients
Comparability of external and internal control patients for the prospective randomized <span>HOVON</span>‐103 trial in older <span>AML</span> patients Open
Summary Real‐world data (RWD) previously contributed to post‐marketing regulatory decision‐making, but are currently also considered as external controls to single‐arm trials. The use of RWD control data may be compromised by methodologica…
View article: The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy
The association between hospital volume and overall survival in adult AML patients treated with intensive chemotherapy Open
View article: Skin cancer risk in more than 200 000 patients with haematological malignancies over 30 years: a nationwide population-based study in the Netherlands
Skin cancer risk in more than 200 000 patients with haematological malignancies over 30 years: a nationwide population-based study in the Netherlands Open
Background Patients with haematological malignancies are at increased risk of developing skin cancer and often experience worse skin cancer-related outcomes. However, there is a lack of nationwide, population-based data with long-term foll…
View article: Quantifying absolute treatment effect heterogeneity for time-to-event outcomes across different risk strata: divergence of conclusions with risk difference and restricted mean survival difference
Quantifying absolute treatment effect heterogeneity for time-to-event outcomes across different risk strata: divergence of conclusions with risk difference and restricted mean survival difference Open
Background Risk-based analyses are increasingly popular for understanding heterogeneous treatment effects (HTE) in clinical trials. For time-to-event analyses, the assumption that high-risk patients benefit most on the clinically important…
View article: Causes of death among patients diagnosed with chronic lymphocytic leukemia: A population‐based study in the Netherlands, 1996–2020
Causes of death among patients diagnosed with chronic lymphocytic leukemia: A population‐based study in the Netherlands, 1996–2020 Open
Chronic lymphocytic leukemia (CLL) manifests heterogeneously with varying outcomes. This population‐based study examined causes of death (CODs), as registered by the physician who established the death, among 20,588 CLL patients diagnosed …
View article: Clonal hematopoiesis and myeloid skewing in older population‐based individuals
Clonal hematopoiesis and myeloid skewing in older population‐based individuals Open
Contains fulltext : 315388.pdf (Publisher’s version ) (Open Access)
View article: Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma
Comparative effectiveness of 6x R-CHOP21 versus 6x R-CHOP21 + 2 R for patients with advanced-stage diffuse large B-cell lymphoma Open
View article: Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? Open
Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, popu…
View article: Treatment and outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma: a contemporary, nationwide, population-based study in the Netherlands
Treatment and outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma: a contemporary, nationwide, population-based study in the Netherlands Open
View article: Characteristics, primary treatment, and survival of MDS/MPN with neutrophilia: a population-based study
Characteristics, primary treatment, and survival of MDS/MPN with neutrophilia: a population-based study Open
Myelodysplastic and myeloproliferative neoplasms (MDS/MPN) with neutrophilia, until recently called atypical chronic myeloid leukemia (aCML), being part of the MDS/MPN is a very rare disease with poor prognosis. Although emerging data reve…
View article: <i>BCR::ABL1</i> kinase domain mutation testing and clinical outcome in a nationwide chronic myeloid leukemia patient population
<i>BCR::ABL1</i> kinase domain mutation testing and clinical outcome in a nationwide chronic myeloid leukemia patient population Open
Objectives Acquired missense mutations in the BCR::ABL1 kinase domain (KD) may cause tyrosine kinase inhibitor (TKI) treatment failure. Based on mutation‐specific in vitro derived IC50‐values, alternative TKI may be selected. We assessed c…
View article: Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort
Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort Open
Contains fulltext : 296654.pdf (Publisher’s version ) (Open Access)
View article: The cancer burden in the oldest‐old: Increasing numbers and disparities—A nationwide study in the Netherlands, 1990 to 2019
The cancer burden in the oldest‐old: Increasing numbers and disparities—A nationwide study in the Netherlands, 1990 to 2019 Open
Adults aged ≥80 years (the oldest‐old) comprise the fastest growing age group in Western populations. Yet little is known about their cancer burden. In this nationwide study, we assessed their trends in incidence, treatment and survival ov…
View article: Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study
Survival disparities between children and adolescents and young adults for the major subtypes of non-Hodgkin lymphoma in the Netherlands: a large population-based study Open
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View article: P1139: COMPARISON OF 6XR-CHOP21 VERSUS 6XR-CHOP+2R FOR ADVANCED-STAGE DIFFUSE LARGE B-CELL LYMPHOMA: A PROPENSITY SCORE WEIGHTED POPULATION-BASED ANALYSIS
P1139: COMPARISON OF 6XR-CHOP21 VERSUS 6XR-CHOP+2R FOR ADVANCED-STAGE DIFFUSE LARGE B-CELL LYMPHOMA: A PROPENSITY SCORE WEIGHTED POPULATION-BASED ANALYSIS Open
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: The standard first-line treatment for most patients with advanced-stage diffuse large B-cell lymphoma (DLBCL) is six cycles of rituximab, cyclophosphamide, doxorubicin, vinc…
View article: P565: REAL-WORLD DATA AS SUPPLEMENTARY CONTROLS FOR THE PROSPECTIVE RANDOMIZED HOVON-103 TRIAL IN INTENSIVELY TREATED ELDERLY ACUTE MYELOID LEUKEMIA PATIENTS
P565: REAL-WORLD DATA AS SUPPLEMENTARY CONTROLS FOR THE PROSPECTIVE RANDOMIZED HOVON-103 TRIAL IN INTENSIVELY TREATED ELDERLY ACUTE MYELOID LEUKEMIA PATIENTS Open
Background: To replace or supplement control patients in prospective phase II/III studies, it has been suggested to use Real-World Data (RWD). However, it is unknown how outcome of RWD patients compares to outcome of trial control patients…
View article: P1128: EVALUATION OF STANDARD OF CARE IN SECOND-LINE FOR PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA IN THE PRE-CAR-T ERA: A DUTCH POPULATION-BASED STUDY
P1128: EVALUATION OF STANDARD OF CARE IN SECOND-LINE FOR PATIENTS WITH RELAPSED OR REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA IN THE PRE-CAR-T ERA: A DUTCH POPULATION-BASED STUDY Open
Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background: Outcomes of patients with diffuse large B-cell lymphoma (DLBCL) who are refractory to or who relapse early after first-line therapy (i.e., “early R/R” DLBCL) are generally p…
View article: Allogeneic Stem Cell Transplantation in Patients >40 Years of Age With Acute Lymphoblastic Leukemia: Reduced Intensity Versus Myeloablative Conditioning
Allogeneic Stem Cell Transplantation in Patients >40 Years of Age With Acute Lymphoblastic Leukemia: Reduced Intensity Versus Myeloablative Conditioning Open
Background. The outcome in older patients with acute lymphoblastic leukemia (ALL) remains unsatisfactory due to high relapse and nonrelapse mortality (NRM) rates. Allogeneic stem cell transplantation (alloHSCT) as postremission therapy has…
View article: No sex differential in relative survival among older patients with DLBCL treated with R-CHOP21: a population-based study
No sex differential in relative survival among older patients with DLBCL treated with R-CHOP21: a population-based study Open
1989 and is widely used in population-based cancer research.To identify potential studies that may have used the same data or part of it, we conducted a thorough literature review using the following search terms in PubMed:("diffuse large …
View article: A non-randomized risk-adjusted comparison of lenalidomide + R-CHOP versus R-CHOP for MYC-rearranged DLBCL patients
A non-randomized risk-adjusted comparison of lenalidomide + R-CHOP versus R-CHOP for MYC-rearranged DLBCL patients Open
Patients with MYC rearranged ( MYC -R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in a single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated a…
View article: Number of life-years lost at the time of diagnosis and several years post-diagnosis in patients with solid malignancies: a population-based study in the Netherlands, 1989–2019
Number of life-years lost at the time of diagnosis and several years post-diagnosis in patients with solid malignancies: a population-based study in the Netherlands, 1989–2019 Open
View article: Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population
Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population Open
View article: High-risk additional cytogenetic aberrations in a Dutch chronic phase chronic myeloid leukemia patient population
High-risk additional cytogenetic aberrations in a Dutch chronic phase chronic myeloid leukemia patient population Open
Contains fulltext : 300052.pdf (Publisher’s version ) (Open Access)
View article: Sex Differences in the Spectrum of Clonal Hematopoiesis
Sex Differences in the Spectrum of Clonal Hematopoiesis Open
\n Contains fulltext :\n 290614.pdf (Publisher’s version ) (Open Access)\n
View article: Impact of Advanced External Beam Radiotherapy on Second Haematological Cancer Risk in Prostate Cancer Survivors
Impact of Advanced External Beam Radiotherapy on Second Haematological Cancer Risk in Prostate Cancer Survivors Open
View article: Risk of second primary malignancies in patients with chronic lymphocytic leukemia: a population-based study in the Netherlands, 1989-2019
Risk of second primary malignancies in patients with chronic lymphocytic leukemia: a population-based study in the Netherlands, 1989-2019 Open