Avinchal Manhas
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View article: <i>Xist</i> upstream deletion leads to dysregulation of <i>Xist</i> and autosomal gene expression
<i>Xist</i> upstream deletion leads to dysregulation of <i>Xist</i> and autosomal gene expression Open
Xist long noncoding RNA is the master regulator of the X-Chromosome inactivation (XCI) process. Xist is expressed from the inactive X and coats the inactive X to facilitate XCI. Cis -regulation of Xist expression remains poorly understood …
View article: Gestational exposure to high heat-humidity conditions impairs mouse embryonic development
Gestational exposure to high heat-humidity conditions impairs mouse embryonic development Open
Unprecedented rates of global warming have created an existential challenge for the sustainable survival of species on this planet. Tropical conditions of high ambient temperature and relative humidity are extremely vulnerable to maternal-…
View article: Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation
Lineage-specific dynamics of erasure of X-upregulation during inactive-X reactivation Open
In mammals, sex chromosome dosage is compensated through X-chromosome inactivation and active-X upregulation. It is believed that during early development, X-chromosome inactivation and active X upregulation happen in a highly coordinated …