Avisek Majumder
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View article: Satoyoshi Syndrome: Difficult to find or treat?
Satoyoshi Syndrome: Difficult to find or treat? Open
Satoyoshi Syndrome, also known as Komuragaeri disease, is a rare multisystemic autoimmune disorder characterised by alopecia, intermittent painful muscle spasms, diarrhoea, endocrinopathies, skeletal deformities, and positivity for antinuc…
View article: Comparative proteomics and structure-based approach to unravel the therapeutic drug target of Theileria species
Comparative proteomics and structure-based approach to unravel the therapeutic drug target of Theileria species Open
View article: Mechanistic Insights Into the Periodontal-Atherosclerotic Axis: From Oral Inflammation to Cardiovascular Pathology
Mechanistic Insights Into the Periodontal-Atherosclerotic Axis: From Oral Inflammation to Cardiovascular Pathology Open
View article: The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process
The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process Open
One-carbon (1C) metabolism is a complex network of metabolic reactions closely related to producing 1C units (as methyl groups) and utilizing them for different anabolic processes, including nucleotide synthesis, methylation, protein synth…
View article: Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic
Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic Open
Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants of the Zingiberaceae family. Cardamom has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammato…
View article: How the Western Diet Thwarts the Epigenetic Efforts of Gut Microbes in Ulcerative Colitis and Its Association with Colorectal Cancer
How the Western Diet Thwarts the Epigenetic Efforts of Gut Microbes in Ulcerative Colitis and Its Association with Colorectal Cancer Open
Ulcerative colitis (UC) is an autoimmune disease in which the immune system attacks the colon, leading to ulcer development, loss of colon function, and bloody diarrhea. The human gut ecosystem consists of almost 2000 different species of …
View article: Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures
Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures Open
In recent years, chimeric antigen receptor (CAR)-T-cell therapy has emerged as the most promising immunotherapy for cancer that typically uses patients’ T cells and genetically engineered them to target cancer cells. Although recent improv…
View article: HER3: Toward the Prognostic Significance, Therapeutic Potential, Current Challenges, and Future Therapeutics in Different Types of Cancer
HER3: Toward the Prognostic Significance, Therapeutic Potential, Current Challenges, and Future Therapeutics in Different Types of Cancer Open
Human epidermal growth factor receptor 3 (HER3) is the only family member of the EGRF/HER family of receptor tyrosine kinases that lacks an active kinase domain (KD), which makes it an obligate binding partner with other receptors for its …
View article: Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment
Targeting Homocysteine and Hydrogen Sulfide Balance as Future Therapeutics in Cancer Treatment Open
A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this condition. Recent studies have shown that cancer cells need…
View article: FUNCTIONAL OUTCOME OF NEGLECTED POSTERIOR ELBOW DISLOCATION MANAGED SURGICALLY BY OPEN REDUCTION IN A NORTH-EAST TERTIARY CENTRE OF INDIA
FUNCTIONAL OUTCOME OF NEGLECTED POSTERIOR ELBOW DISLOCATION MANAGED SURGICALLY BY OPEN REDUCTION IN A NORTH-EAST TERTIARY CENTRE OF INDIA Open
Introduction: Neglected posterior elbow dislocation is common in developing countries. Various treatment methods have been described. Considering the lack of facilities and cost constraints in developing countries, the treatment options ar…
View article: FUNCTIONAL OUTCOME OF NEGLECTED POSTERIOR ELBOW DISLOCATION MANAGED SURGICALLY BY OPEN REDUCTION IN A NORTH-EAST TERTIARY CENTRE OF INDIA
FUNCTIONAL OUTCOME OF NEGLECTED POSTERIOR ELBOW DISLOCATION MANAGED SURGICALLY BY OPEN REDUCTION IN A NORTH-EAST TERTIARY CENTRE OF INDIA Open
Introduction: Neglected posterior elbow dislocation is common in developing countries. Various treatment methods have been described. Considering the lack of facilities and cost constraints in developing countries, the tre…
View article: The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers
The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers Open
HER2 and HER3 play key driving functions in the pathophysiology of HER2-amplified breast cancers, but this function is less well characterized in other cancers driven by HER2 amplification. This study aimed to explore the role of HER2 and …
View article: Effect of <i>MMP-9</i> gene knockout on retinal vascular form and function
Effect of <i>MMP-9</i> gene knockout on retinal vascular form and function Open
Retinal degeneration from inherited gene mutation(s) is a common cause of blindness because of structural and functional alterations in photoreceptors. Accordingly, various approaches are being tested to ameliorate or even cure neuroretina…
View article: Studying Long-term Effects of a Probiotic on Neuroretinal Health
Studying Long-term Effects of a Probiotic on Neuroretinal Health Open
View article: Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis
Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis Open
Findings reveal that HHcy-induced glutamate excitotoxicity, oxidative damage, ER-stress and vascular permeability alone or together can compromise ocular health and that GYY4137 could serve as a potential therapeutic agent for treating HHc…
View article: Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition
Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition Open
Elevated homocysteine (Hcy), i.e., hyperhomocysteinemia (HHcy), causes skeletal muscle myopathy. Among many cellular and metabolic alterations caused by HHcy, oxidative and endoplasmic reticulum (ER) stress are considered the major ones; h…
View article: Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine
Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine Open
To our knowledge, this is the first report profiling circRNAs in human RPE cells post-Hcy treatment mimicking hyperhomocysteinemic (HHcy) conditions that negatively affect retinal biology and vision. These findings are of potential clinica…
View article: Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis
Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis Open
Diabetic patients suffer from a host of physiological abnormalities beyond just those of glucose metabolism. These abnormalities often lead to systemic inflammation via modulation of several inflammation-related genes, their respective gen…
View article: Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-<i>β</i>-synthase mutant mice via PPAR-<i>γ</i>/VEGF axis
Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-<i>β</i>-synthase mutant mice via PPAR-<i>γ</i>/VEGF axis Open
Neoangiogenesis is a fundamental process which helps to meet energy requirements, tissue growth, and wound healing. Although previous studies showed that Peroxisome proliferator-activated receptor (PPAR-γ) regulates neoangiogenesis via upr…
View article: Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury
Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury Open
Although hyperhomocysteinemia (HHcy) occurs because of the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated through oxidative stress, endoplasmic reticulu…
View article: Evaluation of hydrogen sulfide (H2S) effects on visual functions and pyroptosis in a mouse model of hyperhomocysteinemia
Evaluation of hydrogen sulfide (H2S) effects on visual functions and pyroptosis in a mouse model of hyperhomocysteinemia Open
View article: A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration
A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration Open
Age-related macular degeneration (AMD) is a leading cause of blindness and is becoming a global crisis since affected people will increase to 288 million by 2040. Genetics, age, diabetes, gender, obesity, hypertension, race, hyperopia, iri…
View article: Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy.
Effects of hydrogen sulfide in hyperhomocysteinemia-mediated skeletal muscle myopathy. Open
Although hyperhomocysteinemia (HHcy) occurs due to a deficiency in cystathionine-β-synthase (CBS), causing skeletal muscle myopathy, it is still unclear whether this effect is mediated through oxidative, endoplasmic reticulum (ER) stress, …
View article: Post-menopausal breast cancer: from estrogen to androgen receptor
Post-menopausal breast cancer: from estrogen to androgen receptor Open
In the United States, breast cancer is the second leading cause of death among women, and even though different therapies can treat primary breast tumors, most breast cancer-related deaths (>95%) occur due to metastasis. A majority (~70%) …
View article: Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy Open
A detrimental consequence of hypermethylation is hyperhomocysteinemia (HHcy), that causes oxidative stress, inflammation, and matrix degradation, which leads to multi-pathology in different organs. Although, it is well known that hypermeth…