Aviva Geretz
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View article: Full-length next-generation sequencing of 11 HLA loci of more than 1000 individuals from clinical cohorts in East and West Africa
Full-length next-generation sequencing of 11 HLA loci of more than 1000 individuals from clinical cohorts in East and West Africa Open
Human Leukocyte Antigen (HLA) loci have been implicated in several diseases from different world populations, including HIV-1. It is necessary to characterize HLA allele variation at the population level prior to investigating associations…
View article: Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts
Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts Open
Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive ant…
View article: Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts
Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts Open
Elimination of latent HIV-1 is a major goal of AIDS research but the host factors determining the size of these reservoirs are poorly understood. Here, we investigated whether differences in host gene expression modulate the size of the HI…
View article: AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo
AP-1/c-Fos supports SIV and HIV-1 latency in CD4 T cells infected in vivo Open
View article: Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo
Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo Open
Host restriction factors play key roles in innate antiviral defense, but it remains poorly understood which of them restricts HIV-1 in vivo. Here, we used single-cell transcriptomic analysis to identify host factors associated with HIV-1 c…
View article: Data from: "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo<em>"</em>
Data from: "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo<em>"</em> Open
Data needed to recreate main figures/analysis in "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo"
View article: Supplementary data from: "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo"
Supplementary data from: "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo" Open
Data associated with supplementary figures in "Single cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo"
View article: HLA-B*57 and B*58 Associate with Predictors of Reservoir Size in an Acutely Treated HIV Cohort
HLA-B*57 and B*58 Associate with Predictors of Reservoir Size in an Acutely Treated HIV Cohort Open
Much has been learnt about the role of human leukocyte antigen (HLA) alleles during natural infection of HIV-1, but far less is known about their role in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). In this st…
View article: Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells
Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells Open
U.S. National Institutes of Health and U.S. Department of Defense.
View article: HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype
HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype Open
View article: Data from: HLA-B*46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype
Data from: HLA-B*46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype Open
Data needed to create figures in " HLA-B*46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype" (Li, Hickey, Shangguan et al.)
View article: Associations of human leukocyte antigen with neutralizing antibody titers in a tetravalent dengue vaccine phase 2 efficacy trial in Thailand
Associations of human leukocyte antigen with neutralizing antibody titers in a tetravalent dengue vaccine phase 2 efficacy trial in Thailand Open
The recombinant, live, attenuated, tetravalent dengue vaccine CYD-TDV has shown efficacy against all four dengue serotypes. In this exploratory study (CYD59, NCT02827162), we evaluated potential associations of host human leukocyte antigen…
View article: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1
Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1 Open
A gene signature was previously found to be correlated with mosaic adenovirus 26 vaccine protection in simian immunodeficiency virus and simian-human immunodeficiency virus challenge models in non-human primates. In this report, we investi…
View article: Author response: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1
Author response: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1 Open
View article: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as the primary mechanism of vaccine-induced protection against HIV-1
Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as the primary mechanism of vaccine-induced protection against HIV-1 Open
A gene signature previously correlated with mosaic adenovirus 26 vaccine protection in simian immunodeficiency virus (SIV) and SHIV challenge models in non-human primates (NHP). In this report we investigated presence of this signature as …
View article: B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies
B cell engagement with HIV-1 founder virus envelope predicts development of broadly neutralizing antibodies Open
View article: Data from: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1
Data from: Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as a potential mechanism of vaccine-induced protection against HIV-1 Open
Data and metadata needed to create figures in "Monocyte-derived transcriptome signature indicates antibody-dependent cellular phagocytosis as the primary mechanism of vaccine-induced protection against HIV-1" (Shangguan, S., et. al.)
View article: Next-generation sequencing of 11 HLA loci in a large dengue vaccine cohort from the Philippines
Next-generation sequencing of 11 HLA loci in a large dengue vaccine cohort from the Philippines Open
View article: Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor Open
View article: Single cell RNA-seq identifies host genes that correlate with HIV-1 reservoir size
Single cell RNA-seq identifies host genes that correlate with HIV-1 reservoir size Open
View article: Single-cell transcriptome of in vivo SIV-infected rhesus macaque CD4 T cells
Single-cell transcriptome of in vivo SIV-infected rhesus macaque CD4 T cells Open
View article: A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials
A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials Open
A gene signature in B cells associates with protective efficacy of different vaccine regimens against SIV and HIV infection.
View article: Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity Open
The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex (PLC) components is expe…
View article: Author response: Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
Author response: Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The highly polymorphic human …
View article: <scp>HLA</scp>class<scp>II</scp>diversity in<scp>HIV</scp>‐1 uninfected individuals from the placebo arm of the<scp>RV144</scp>Thai vaccine efficacy trial
<span>HLA</span>class<span>II</span>diversity in<span>HIV</span>‐1 uninfected individuals from the placebo arm of the<span>RV144</span>Thai vaccine efficacy trial Open
The RV144 HIV vaccine trial in Thailand elicited antibody responses to the envelope of HIV ‐1, which correlated significantly with the risk of HIV ‐1 acquisition. Human leukocyte antigen ( HLA ) class II molecules are essential in antigen …