Aviva Witkover
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View article: The impact of HTLV-1 expression on the 3D structure and expression of host chromatin
The impact of HTLV-1 expression on the 3D structure and expression of host chromatin Open
A typical HTLV-1-infected individual carries >10 4 different HTLV-1-infected T cell clones, each with a single-copy provirus integrated in a unique genomic site. We previously showed that the HTLV-1 provirus causes aberrant transcription i…
View article: The impact of HTLV-1 expression on the 3D structure and expression of host chromatin
The impact of HTLV-1 expression on the 3D structure and expression of host chromatin Open
A typical HTLV-1-infected individual carries >10 4 different HTLV-1-infected T cell clones, each with a single-copy provirus integrated in a unique genomic site. We previously showed that the HTLV-1 provirus causes aberrant transcription i…
View article: Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis
Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis Open
Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy caused by human T-cell leukemia virus type-1 (HTLV-1). ATL is preceded by decades of chronic HTLV-1 infection, and the tumors carry both somatic mutations and p…
View article: Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab
Molecular remissions are observed in chronic adult T-cell leukemia/lymphoma in patients treated with mogamulizumab Open
International audience
View article: Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia
Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia Open
Human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus coinfection is frequent in certain Indigenous Australian populations, but its outcome remains unknown. We report a higher degree of HTLV-1 clonal expansion than in those…
View article: The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis
The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis Open
Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact o…
View article: Author response: The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis
Author response: The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Chromatin looping controls gene expression…
View article: The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin <i>in cis</i>
The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin <i>in cis</i> Open
Chromatin looping controls gene expression by regulating promoter-enhancer contacts, the spread of epigenetic modifications, and the segregation of the genome into transcriptionally active and inactive compartments. We studied the impact o…
View article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Open
Background: A major cause of disability in secondary progressive multiple sclerosis (SPMS) is progressive brain atrophy, whose pathogenesis is not fully understood. The objective of this study was to identify protein biomarkers of brain at…
View article: T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells
T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells Open
There is growing evidence that CD8+ cytotoxic T lymphocyte (CTL) responses can contribute to long-term remission of many malignancies. The etiological agent of adult T-cell leukemia/lymphoma (ATL), human T lymphotropic virus type-1 (HTLV-1…
View article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Open
Background: A major cause of disability in secondary progressive multiple sclerosis (SPMS) is progressive brain atrophy, whose pathogenesis is not fully understood. The objective of this study was to identify protein biomarkers of brain at…
View article: Raw Data For Rbc, Hb And Haematocrit From Article: Free Serum Haemoglobin Is Associated With Brain Atrophy In Secondary Progressive Multiple Sclerosis
Raw Data For Rbc, Hb And Haematocrit From Article: Free Serum Haemoglobin Is Associated With Brain Atrophy In Secondary Progressive Multiple Sclerosis Open
Erythrocyte count, total blood haemoglobin and haematocrit levels at the first and fifth clinical visit.
View article: Raw data for SELDI-TOF low range from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Raw data for SELDI-TOF low range from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Open
Raw normalised data from SELDI-TOF at low range following Expression Difference Mapping (ProteinChip Data Manager. Bio-Rad). Columns contain sample name, sample group (corresponds to longitudinal measurements for each patients at 1,3,4 and…
View article: Raw data for SELDI-TOF high range from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Raw data for SELDI-TOF high range from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Open
Raw normalised data from SELDI-TOF at high range following Expression Difference Mapping (ProteinChip Data Manager. Bio-Rad). Columns contain sample name, sample group (corresponds to longitudinal measurements for each patients at 1,3,4 an…
View article: Nano LC MS-MS peptide matches from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis
Nano LC MS-MS peptide matches from article: Free serum haemoglobin is associated with brain atrophy in secondary progressive multiple sclerosis Open
Protein peaks associated with brain atrophy: identification by liquid chromatography-electrospray ionization tandem mass spectrometry
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\nRelative molecular mass, protein score and identity of the genes with sequence matches to peptide fr…