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View article: Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics
Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics Open
The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli‐responsive microcapsules, lo…
View article: Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics
Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics Open
The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli‐responsive microcapsules, lo…
View article: Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study
Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study Open
Background: Viral infection is associated with a significant rewire of the host metabolic pathways, presenting attractive metabolic targets for intervention. Methods: We chart the metabolic response of lung epithelial cells to SARS-CoV-2 i…
View article: Effect of SARS-CoV-2 proteins on vascular permeability
Effect of SARS-CoV-2 proteins on vascular permeability Open
Severe acute respiratory syndrome (SARS)-CoV-2 infection leads to severe disease associated with cytokine storm, vascular dysfunction, coagulation, and progressive lung damage. It affects several vital organs, seemingly through a pathologi…
View article: Metabolic Regulation of SARS-CoV-2 Infection
Metabolic Regulation of SARS-CoV-2 Infection Open
Viruses are efficient metabolic engineers that actively rewire host metabolic pathways to support their lifecycle, presenting attractive metabolic targets for intervention. Here we chart the metabolic response of lung epithelial cells to S…
View article: Effect of SARS-CoV-2 proteins on vascular permeability
Effect of SARS-CoV-2 proteins on vascular permeability Open
SARS-CoV-2 infection leads to severe disease associated with cytokine storm, vascular dysfunction, coagulation, and progressive lung damage. It affects several vital organs, seemingly through a pathological effect on endothelial cells. The…
View article: Mechanism and reversal of drug-induced nephrotoxicity on a chip
Mechanism and reversal of drug-induced nephrotoxicity on a chip Open
Sensor-embedded spheroids-on-a-chip reveal the mechanisms of cisplatin- and cyclosporine-induced nephrotoxicity and identify a potential therapeutic.
View article: Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin
Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin Open
Biocatalytic control over the stiffness of pH-responsive hydrogels is applied to develop shape-memory, self-healing and controlled release matrices.
View article: Challenges and Opportunities in the Design of Liver-on-Chip Microdevices
Challenges and Opportunities in the Design of Liver-on-Chip Microdevices Open
The liver is the central hub of xenobiotic metabolism and consequently the organ most prone to cosmetic- and drug-induced toxicity. Failure to detect liver toxicity or to assess compound clearance during product development is a major caus…
View article: Microphysiological flux balance platform unravels the dynamics of drug induced steatosis
Microphysiological flux balance platform unravels the dynamics of drug induced steatosis Open
Sensor-integrated liver chip unravels risks of drug-induced fatty liver disease associated with prescription drug use.