Explanipedia

Postnatal antibiotic exposure due to maternal group B streptococcus is associated with childhood asthma Open

Eyal Kristal, Itamar Ben Shitrit, Yoram Faitelson, Guy Hazan, Avraham Beigelman · 2025

Background Previous studies identified early‐life antibiotic exposure as a risk factor for childhood asthma. However, this association may be confounded by an indication, as antibiotics are often prescribed for respiratory infections, whic…

The impact of neonatal antibiotic exposure on the development of childhood food allergies Open

Mai Ofri, Eyal Kristal, Brian M. Cohen, Avraham Beigelman, Guy Hazan · 2025

Food allergies (FAs) in children have become increasingly prevalent. While early life factors such as gut microbiome disruptions have been implicated, the association between neonatal antibiotic exposure and subsequent FAs remains a topic …

The Fungal Microbiome of the Upper Airway Is Associated With Future Loss of Asthma Control and Exacerbation Among Children With Asthma Open

Hanshu Yuan, Zhongmao Liu, Jinhong Dong, Leonard B. Bacharier, Daniel J. Jackson , et al. · 2023

Issue Information Open

Carina Venter, R.W. Frei, Giulia Carla Immacolata Spolidoro, Yohannes Tesfaye Amera, Mohd Shaiful Aziz Rashid Ali , et al. · 2023

Early‐life fecal metabolomics of food allergy Open

Kathleen Lee‐Sarwar, Yih‐Chieh Chen, Jessica Lasky‐Su, Rachel S. Kelly, Robert S. Zeiger , et al. · 2022

Background Intestinal microenvironmental perturbations may increase food allergy risk. We hypothesize that children with clinical food allergy, those with food sensitization, and healthy children can be differentiated by intestinal metabol…

The maternal prenatal and offspring <span>early‐life</span> gut microbiome of childhood asthma phenotypes Open

Kathleen Lee‐Sarwar, Yih‐Chieh Chen, Yuan Yao Chen, Anita L. Kozyrskyj, Piush J. Mandhane , et al. · 2022

Background The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the maternal microbiome, and how the microbiome impacts different childhood asthma ph…

Dietary Indian frankincense (Boswellia serrata) ameliorates murine allergic asthma through modulation of the gut microbiome Open

Cassandra Suther, Liv Devon, Lauren Daddi, Adam Matson, Hunter Panier , et al. · 2022

Azithromycin to Prevent Recurrent Wheeze Following Severe Respiratory Syncytial Virus Bronchiolitis Open

Avraham Beigelman, Mythili Srinivasan, Charles W. Goss, Jinli Wang, Yanjiao Zhou , et al. · 2022

Azithromycin therapy for 14 days during acute severe RSV bronchiolitis did not reduce recurrent wheeze occurrence over the following 2 to 4 years. Our data suggest no benefit of azithromycin administration with the goal of preventing recur…

Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma Open

Kathleen Lee‐Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger , et al. · 2022

The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood Open

Yih‐Chieh S. Chen, Hooman Mirzakhani, Mengdi Lu, Robert S. Zeiger, George O'connor , et al. · 2021

The azithromycin to prevent wheezing following severe RSV bronchiolitis-II clinical trial: Rationale, study design, methods, and characteristics of study population Open

Mythili Srinivasan, Leonard B. Bacharier, Charles W. Goss, Yanjiao Zhou, Jonathan Boomer , et al. · 2021

IgE and T Cell Reactivity to a Comprehensive Panel of Cockroach Allergens in Relation to Disease Open

Anna Pomés, Véronique Schulten, Jill Glesner, Ricardo da Silva Antunes, Aaron Sutherland , et al. · 2021

IgE sensitization to cockroach allergens is associated with development of allergic diseases, such as asthma. To understand the relevance of different cockroach allergens for diagnosis and immunotherapy, a comprehensive analysis of IgE ant…

Geography, generalisability, and susceptibility in clinical trials Open

Jane E. Clougherty, Ellen Kinnee, Juan Carlos Cardet, David T. Mauger, Leonard B. Bacharier , et al. · 2021

Association of the Gut Microbiome and Metabolome with Wheeze Frequency in Childhood Asthma Open

Kathleen Lee‐Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger , et al. · 2021

The Gut Microbiome and the Big Eight Open

Cassandra Suther, Matthew D. Moore, Avraham Beigelman, Yanjiao Zhou · 2020

Food allergies are increasing at an alarming rate, with 6.5% of the general population affected. It has been hypothesized that the increase in allergies stems from the “hygiene hypothesis”. The gut microbiome, a collection of microbiota an…

Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels Open

Chris McKennan, Katherine A. Naughton, Catherine T. Stanhope, Meyer Kattan, George O'connor , et al. · 2020

Epigenetic architecture is influenced by genetic and environmental factors, but little is known about their relative contributions or longitudinal dynamics. Here, we studied DNA methylation (DNAm) at over 750,000 CpG sites in mononuclear b…

Synchronization of mothers and offspring promotes tolerance and limits allergy Open

Kathryn Knoop, Keely G. McDonald, Paige Coughlin, Devesha H. Kulkarni, Jenny K. Gustafsson , et al. · 2020

Allergic disorders, characterized by Th2 immune responses to environmental substances, are increasingly common in children in Western societies. Multiple studies indicate that breastfeeding, early complementary introduction of food allerge…

Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma Open

Juliana Durack, Laura S. Christian, Snehal Nariya, Jeanmarie R. Gonzalez, Nirav R. Bhakta , et al. · 2020

Heterogeneity of Mild to Moderate Persistent Asthma in Children: Confirmation by Latent Class Analysis and Association with 1-Year Outcomes Open

Anne M. Fitzpatrick, Leonard B. Bacharier, Daniel J. Jackson, Stanley J. Szefler, Avraham Beigelman , et al. · 2020

Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction Open

Augusto A. Litonjua, Vincent J. Carey, Nancy Laranjo, Benjamin J. Stubbs, Hooman Mirzakhani , et al. · 2020

Vitamin D supplementation during the prenatal period alone did not influence the 6-year incidence of asthma and recurrent wheeze among children who were at risk for asthma. (Funded by the National Heart, Lung, and Blood Institute; VDAART C…

Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology Open

Matthew C. Altman, Avraham Beigelman, Christina E. Ciaccio, James E. Gern, Peter W. Heymann , et al. · 2020

The upper-airway microbiota and loss of asthma control among asthmatic children Open

Yanjiao Zhou, Daniel J. Jackson, Leonard B. Bacharier, David T. Mauger, Homer A. Boushey , et al. · 2019

Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma Open

Michael E. Wechsler, Stanley J. Szefler, Victor E. Ortega, Jacqueline A. Pongracic, Vernon M. Chinchilli , et al. · 2019

In contrast to black adolescents and adults, almost half the black children with poorly controlled asthma had a superior response to an increase in the dose of an inhaled glucocorticoid and almost half had a superior response to the additi…

Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes Open

Kathleen Lee‐Sarwar, Rachel S. Kelly, Jessica Lasky‐Su, Robert S. Zeiger, George O'connor , et al. · 2019

Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children Open

Matthew C. Altman, Michelle A. Gill, Elizabeth Whalen, Denise C. Babineau, Baomei Shao , et al. · 2019

Integrative analysis of the intestinal metabolome of childhood asthma Open

Kathleen Lee‐Sarwar, Rachel S. Kelly, Jessica Lasky‐Su, Robert S. Zeiger, George O'connor , et al. · 2019

Association of the Infant Gut Microbiome With Early Childhood Neurodevelopmental Outcomes Open

Joanne E. Sordillo, Susan Korrick, Nancy Laranjo, Vincent J. Carey, George M. Weinstock , et al. · 2019

These findings suggest an association between infant gut microbiome composition and communication, personal and social, and fine motor skills at age 3 years. The majority of associations were driven by taxa within the order Clostridiales.

Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors Open

Giovanni Birrueta, April Frazier, Anna Pomés, Jill Glesner, Stephanie Filep , et al. · 2019

German cockroach extract is used clinically to evaluate allergen-specific sensitization and for subcutaneous allergen-specific immunotherapy, though there are no guidelines for standardization in its manufacture. We performed an immunologi…

Integrative Analysis of the Intestinal Metabolome of Childhood Asthma Open

Kathleen Lee‐Sarwar, Rachel S. Kelly, Jessica Lasky‐Su, Robert S. Zeiger, George O'connor , et al. · 2019

Type-1 Interferon and Th2-Type Gene Expression Responses and Childhood Asthma Open

Jamie A. Rosenthal, Malisa T. Smith, Michelle A. Gill, Andrew H. Liu, Rebecca S. Gruchalla , et al. · 2019

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