Axel Haferkamp
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View article: Complications and oncologic outcome in bladder cancer patients receiving radical cystectomy after intravesical instillation treatment
Complications and oncologic outcome in bladder cancer patients receiving radical cystectomy after intravesical instillation treatment Open
Objective To evaluate the impact of previous intravesical treatment with Bacillus Calmette-Guérin (BCG) or mitomycin on postoperative complications and oncologic outcome in non-muscle invasive bladder cancer (NMIBC) patients receiving radi…
View article: App-based therapy for female patients with urinary incontinence in Germany (DINKS): a single-blind, randomised, controlled trial
App-based therapy for female patients with urinary incontinence in Germany (DINKS): a single-blind, randomised, controlled trial Open
Kranus Health.
View article: Mistletoe Extracts Inhibit Progressive Growth of Prostate Cancer Cells
Mistletoe Extracts Inhibit Progressive Growth of Prostate Cancer Cells Open
Although multimodal therapeutic management has significantly improved outcome in prostate cancer (PCa) patients, treatment options for castrate-resistant disease remain challenging. Plant-derived mistletoe extracts have supported cancer pa…
View article: Impact of the PI-QUAL MRI quality score on histopathological up-staging from MRI fusion biopsy to final prostatectomy specimen
Impact of the PI-QUAL MRI quality score on histopathological up-staging from MRI fusion biopsy to final prostatectomy specimen Open
Purpose The qualitative heterogeneity of multiparametric MRI (mpMRI) poses significant challenges for the diagnostic pathway of prostate cancer (PCa). The Prostate Imaging Quality Score (PI-QUAL) is a novel tool for the qualitative assessm…
View article: Sacral Neurostimulation in Neurogenic Lower Urinary Tract and Bowel Dysfunction Caused by Multiple System Atrophy
Sacral Neurostimulation in Neurogenic Lower Urinary Tract and Bowel Dysfunction Caused by Multiple System Atrophy Open
Objective Multiple system atrophy (MSA) is a progressive neurodegenerative disorder categorized as an atypical Parkinsonian syndrome, affecting extrapyramidal, pyramidal, cerebellar, and autonomic systems. Lower urinary tract dysfunction (…
View article: Retroperitoneal Versus Transperitoneal Robot Assisted Partial Nephrectomy: A Prospective Controlled Non‐Randomized Single Centre Study Non‐Inferiority Design
Retroperitoneal Versus Transperitoneal Robot Assisted Partial Nephrectomy: A Prospective Controlled Non‐Randomized Single Centre Study Non‐Inferiority Design Open
Background The value of the retroperitoneal (R‐RAPN) compared with the conventional transperitoneal (T‐RAPN) approach in robot‐assisted partial nephrectomy has not been finally clarified. The current work's objective was to prospectively i…
View article: Zuverlässigkeit von digitalen Gesundheitsinformationen zur Belastungsinkontinenz im Vergleich zwischen verschiedenen Plattformen
Zuverlässigkeit von digitalen Gesundheitsinformationen zur Belastungsinkontinenz im Vergleich zwischen verschiedenen Plattformen Open
View article: Artesunate Inhibits Metastatic Potential in Cisplatin-Resistant Bladder Cancer Cells by Altering Integrins
Artesunate Inhibits Metastatic Potential in Cisplatin-Resistant Bladder Cancer Cells by Altering Integrins Open
The survival of patients with locally advanced and metastatic bladder cancer (BCa) is persistently low. Hence, new treatment options are urgently needed. Artesunate (ART) a derivative of artemisinin, used in Traditional Chinese Medicine, s…
View article: RCC-Ma loss predicts poor survival and metastatic risk in clear cell renal cell carcinoma
RCC-Ma loss predicts poor survival and metastatic risk in clear cell renal cell carcinoma Open
View article: Real-world comparison of the efficacy of first-line therapies and the influence of risk factors in advanced renal cell carcinoma
Real-world comparison of the efficacy of first-line therapies and the influence of risk factors in advanced renal cell carcinoma Open
Introduction Systemic therapy for advanced renal cell carcinoma (aRCC) has become increasingly diverse. In the 1st-line setting, various combination therapies are available, with little comparative data on the efficacy of the therapies. Th…
View article: Development of an artificial intelligence-generated, explainable treatment recommendation system for urothelial carcinoma and renal cell carcinoma to support multidisciplinary cancer conferences
Development of an artificial intelligence-generated, explainable treatment recommendation system for urothelial carcinoma and renal cell carcinoma to support multidisciplinary cancer conferences Open
This study demonstrates for the first time AI-generated, explainable TR in UC and RCC with excellent performance results as a potential support tool for high-quality, evidence-based TR in MCC. The comprehensive technical and clinical devel…
View article: Development of an artificial intelligence-generated, explainable treatment recommendation system for urothelial carcinoma and renal cell carcinoma to support multidisciplinary cancer conferences
Development of an artificial intelligence-generated, explainable treatment recommendation system for urothelial carcinoma and renal cell carcinoma to support multidisciplinary cancer conferences Open
Background and Objective Decisions on the best available treatment in clinical oncology are based on expert opinions in multidisciplinary cancer conferences (MCC). Artificial intelligence (AI) could increase evidence-based treatment by gen…
View article: A Rare Case of Primary Signet Ring Cell Carcinoma of the Urinary Bladder in a Young Woman
A Rare Case of Primary Signet Ring Cell Carcinoma of the Urinary Bladder in a Young Woman Open
Primary signet ring cell carcinoma of the urinary bladder (PSRCCB) is an exceedingly rare subtype of urinary bladder carcinoma, comprising 0.12%–0.6% of cases, with a poor prognosis. This case report details a distinctive case of a 32‐year…
View article: App-Based Therapy for Female Urinary Incontinence: A Randomized Controlled Trial
App-Based Therapy for Female Urinary Incontinence: A Randomized Controlled Trial Open
View article: P210 Correlation of pulmonary function and radiographic changes in patients with testicular cancer receiving polychemotherapy including bleomycin
P210 Correlation of pulmonary function and radiographic changes in patients with testicular cancer receiving polychemotherapy including bleomycin Open
View article: Growth of Renal Cancer Cell Lines Is Strongly Inhibited by Synergistic Activity of Low-Dosed Amygdalin and Sulforaphane
Growth of Renal Cancer Cell Lines Is Strongly Inhibited by Synergistic Activity of Low-Dosed Amygdalin and Sulforaphane Open
Background: Plant derived isolated compounds or extracts enjoy great popularity among cancer patients, although knowledge about their mode of action is unclear. The present study investigated whether the combination of two herbal drugs, th…
View article: Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway
Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway Open
Tissue transglutaminase 2 (TGM2) and matrix metalloproteinase 7 (MMP7) are suggested to be involved in cancer development and progression, however, their specific role in colon cancer remains elusive. The present study investigated whether…
View article: Radical cystectomy in patients aged < 80 years versus ≥ 80 years: analysis of preoperative geriatric assessment scores in predicting postoperative morbidity and mortality
Radical cystectomy in patients aged < 80 years versus ≥ 80 years: analysis of preoperative geriatric assessment scores in predicting postoperative morbidity and mortality Open
View article: Inhibition of the Sterol Regulatory Element Binding Protein SREBF-1 Overcomes Docetaxel Resistance in Advanced Prostate Cancer
Inhibition of the Sterol Regulatory Element Binding Protein SREBF-1 Overcomes Docetaxel Resistance in Advanced Prostate Cancer Open
View article: ASO Author Reflections: Temporal Trends in Urinary Diversion in Radical Cystectomies from Europe’s Largest Monocentric Cohort with 2224 Cases Over 36 Years
ASO Author Reflections: Temporal Trends in Urinary Diversion in Radical Cystectomies from Europe’s Largest Monocentric Cohort with 2224 Cases Over 36 Years Open
Radical cystectomy (RC) is one of the most complex operative procedures in urology, and choice of urinary diversion (UD) has undergone significant changes over the last decades.While several nationwide analyses revealed overall higher rate…
View article: Temporal Trends in Urinary Diversion among Patients Undergoing Radical Cystectomy Between 1986 and 2022: Experience at the University Medical Center Mainz with 2224 Cases
Temporal Trends in Urinary Diversion among Patients Undergoing Radical Cystectomy Between 1986 and 2022: Experience at the University Medical Center Mainz with 2224 Cases Open
View article: Survey of Physicians and Healers Using Amygdalin to Treat Cancer Patients
Survey of Physicians and Healers Using Amygdalin to Treat Cancer Patients Open
Amygdalin is purported to exhibit anti-cancer properties when hydrolyzed to hydrogen cyanide (HCN). However, knowledge about amygdalin efficacy is limited. A questionnaire evaluating the efficacy, treatment, and dosing protocols, reasons f…
View article: Challenges and perspectives in use of artificial intelligence to support treatment recommendations in clinical oncology
Challenges and perspectives in use of artificial intelligence to support treatment recommendations in clinical oncology Open
Artificial intelligence (AI) promises to be the next revolutionary step in modern society. Yet, its role in all fields of industry and science need to be determined. One very promising field is represented by AI‐based decision‐making tools…
View article: Comparative Retrospective Assessment of the Effectiveness and Risk Factors of Fluoroquinolones, Cephalosporines, and Selective Antibiotic Prophylaxis for Transrectal Prostate Biopsy
Comparative Retrospective Assessment of the Effectiveness and Risk Factors of Fluoroquinolones, Cephalosporines, and Selective Antibiotic Prophylaxis for Transrectal Prostate Biopsy Open
Introduction: Despite increasing resistance of enterobacteria against fluoroquinolones (FLU), they are still widely used during transrectal prostate biopsy (TRPB). This study was designed to analyse infectious complications and risk factor…
View article: Value of perilesional biopsies in multiparametric magnetic resonance imaging-targeted biopsy and systematic biopsy in detection of prostate cancer: results of a prospective, non-randomized, surgeon-blinded study
Value of perilesional biopsies in multiparametric magnetic resonance imaging-targeted biopsy and systematic biopsy in detection of prostate cancer: results of a prospective, non-randomized, surgeon-blinded study Open
Purpose The goal of this study is to address if detection rates of clinically significant prostate cancer (csPCa) can be increased by additional perilesional biopsies (PB) in magnetic resonance (MR)/ultrasound fusion prostate biopsy in bio…
View article: Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro
Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro Open
Only 20% of patients with muscle-invasive bladder carcinoma respond to cisplatin-based chemotherapy. Since the natural phytochemical sulforaphane (SFN) exhibits antitumor properties, its influence on the adhesive and migratory properties o…
View article: Enhanced Recovery After Surgery (ERAS) versus standard recovery after radical cystectomy – a matched-pair analysis
Enhanced Recovery After Surgery (ERAS) versus standard recovery after radical cystectomy – a matched-pair analysis Open
Background Radical cystectomy (RC) is marked by a tremendous potential for short and long-term complications. By introduction of Enhanced Recovery After Surgery (ERAS) protocols serious endeavors have been made in order to reduce postopera…
View article: 25P Change in splenic volume as a surrogate marker for immunotherapy response in patients with advanced urothelial and renal cell carcinoma: Evaluation of a novel approach of fully automated artificial intelligence based splenic segmentation
25P Change in splenic volume as a surrogate marker for immunotherapy response in patients with advanced urothelial and renal cell carcinoma: Evaluation of a novel approach of fully automated artificial intelligence based splenic segmentation Open
In the treatment of advanced urothelial (aUC) and renal cell carcinoma (aRCC), biomarkers such as PD-1 and PD-L1 are not robust prognostic markers for immunotherapy (IO) response. Previously, a significant association between IO and a chan…
View article: Digital informed consent for urological surgery - randomized controlled study comparing multimedia-supported vs. traditional paper-based informed consent concerning satisfaction, anxiety, information gain and time efficiency
Digital informed consent for urological surgery - randomized controlled study comparing multimedia-supported vs. traditional paper-based informed consent concerning satisfaction, anxiety, information gain and time efficiency Open
Introduction Due to a lack of time and staff, informed consent (IC) in clinical practice often lacks clarity, comprehensibility and scope of information. Digital media offer great potential to enhance IC. Aim of this study is to evaluate t…
View article: Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation
Mistletoe Extracts from Different Host Trees Disparately Inhibit Bladder Cancer Cell Growth and Proliferation Open
Extracts of European mistletoe (Viscum album) are popular as a complementary treatment for patients with many different cancer types. However, whether these extracts actually block bladder cancer progression remains unknown. The influence …