Axel Kornerup Hansen
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View article: Gut Microbiota Composition Correlates to Trunk Fat Percentage in Male Cynomolgus Macaque Monkeys
Gut Microbiota Composition Correlates to Trunk Fat Percentage in Male Cynomolgus Macaque Monkeys Open
Obesity and its co‐morbidities are increasing as public health challenges worldwide. Non‐human primates with their similarity to human physiology and susceptibility to metabolic diseases represent a valuable, clinically translational anima…
View article: Liraglutide upregulates the <i>Cftr</i> gene and regulates the mucus transcriptome profile in Brunner's glands in mice
Liraglutide upregulates the <i>Cftr</i> gene and regulates the mucus transcriptome profile in Brunner's glands in mice Open
Background The metabolic syndrome encompasses a state of inflammation and metabolic dysfunction, possibly mediated via a disturbed intestinal barrier. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), such as liraglutide, have shown pr…
View article: Fractionation increasingly reduces FLASH sparing for acute murine skin damage
Fractionation increasingly reduces FLASH sparing for acute murine skin damage Open
Fractionation increasingly reduced the acute skin-sparing effect seen in single-fraction FLASH studies. However, a tissue-sparing effect of 18 % was still present at four fractions, while eight fractions provided a nonsignificant 5 % FLASH…
View article: Infectious scleritis: a comprehensive narrative review of epidemiology, clinical characteristics, and management strategies
Infectious scleritis: a comprehensive narrative review of epidemiology, clinical characteristics, and management strategies Open
This study aims to provide an update on infectious scleritis (IS). A comprehensive search was conducted using Google Scholar, Scopus, and PubMed. IS is a rare but critical condition that presents significant diagnostic challenges and often…
View article: Housing matters: Experimental variables shaping metabolism in obese mice
Housing matters: Experimental variables shaping metabolism in obese mice Open
View article: Investigating fecal microbiota transplants from individuals with anorexia nervosa in antibiotic-treated mice using a cross-over study design
Investigating fecal microbiota transplants from individuals with anorexia nervosa in antibiotic-treated mice using a cross-over study design Open
Anorexia nervosa (AN) is a complex and serious mental disorder, which may affect individuals of all ages and sex, but primarily affecting young women. The disease is characterized by a disturbed body image, restrictive eating behavior, and…
View article: The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice
The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice Open
Background/Objectives: Antibiotics have a significant impact on the gut microbiota, and we hypothesized that human milk oligosaccharides may alleviate antibiotic-induced gut microbiota dysbiosis. Methods: Six groups of eight mice were admi…
View article: Effects of Dairy Matrix on the Intestinal, Liver, and Bone Transcriptome of Healthy Rats
Effects of Dairy Matrix on the Intestinal, Liver, and Bone Transcriptome of Healthy Rats Open
Fermentation is one of the oldest food processing techniques and is widely utilized in dairy product processing, during which nutrient availability and bioactive compounds are altered. However, the complete mode of action by which fermente…
View article: Schistosoma mansoni-induced host immunopathology is gut microbiota dependent
Schistosoma mansoni-induced host immunopathology is gut microbiota dependent Open
Despite progress in schistosomiasis control during recent decades in endemic areas, this parasitic blood-fluke infection continues to pose a substantial public health burden. In depth understanding of the mechanisms behind the complex immu…
View article: THE POLITICS OF MACHINE-LEARNING EVALUATION: FROM LAB TO INDUSTRY
THE POLITICS OF MACHINE-LEARNING EVALUATION: FROM LAB TO INDUSTRY Open
Artificial Intelligence (AI) applications are today implemented across various societal sectors, ranging from health care and security to taking part in shaping the media environment we encounter online. In the last decade there has been a…
View article: Fractionation Increasingly Reduces Flash Sparing for Acute Murine Skin Damage
Fractionation Increasingly Reduces Flash Sparing for Acute Murine Skin Damage Open
View article: Impact of Oxygen Deprivation on the FLASH Effect for Skin Toxicity in a Murine model
Impact of Oxygen Deprivation on the FLASH Effect for Skin Toxicity in a Murine model Open
View article: Wild-Mouse-Derived Gut Microbiome Transplantation in Laboratory Mice Partly Alleviates House-Dust-Mite-Induced Allergic Airway Inflammation
Wild-Mouse-Derived Gut Microbiome Transplantation in Laboratory Mice Partly Alleviates House-Dust-Mite-Induced Allergic Airway Inflammation Open
Laboratory mice are instrumental for preclinical research but there are serious concerns that the use of a clean standardized environment for specific-pathogen-free (SPF) mice results in poor bench-to-bedside translation due to their immat…
View article: Effect of carrot intake on glucose tolerance, microbiota, and gene expression in a type 2 diabetes mouse model
Effect of carrot intake on glucose tolerance, microbiota, and gene expression in a type 2 diabetes mouse model Open
Type 2 diabetes (T2D) pathophysiology involves insulin resistance (IR) and inadequate insulin secretion. Current T2D management includes dietary adjustments and/or oral medications such as thiazolidinediones (TZDs). Carrots have shown to c…
View article: Low‐gainer diet‐induced obese microbiota transplanted mice exhibit increased fighting
Low‐gainer diet‐induced obese microbiota transplanted mice exhibit increased fighting Open
Weight gain variation is a great challenge in diet‐induced obesity studies since low‐gainer animals are of limited experimental value. The inbred C57BL/6 (B6) mice are frequently used models due to their genetic homogeneity and susceptibil…
View article: Probiotic treatment with viable <scp>α‐galactosylceramide</scp>‐producing <i>Bacteroides fragilis</i> reduces diabetes incidence in female nonobese diabetic mice
Probiotic treatment with viable <span>α‐galactosylceramide</span>‐producing <i>Bacteroides fragilis</i> reduces diabetes incidence in female nonobese diabetic mice Open
Background We aimed to investigate whether alpha‐galactosylceramide (α‐GalCer)‐producing Bacteroides fragilis could induce natural killer T (NKT) cells in nonobese diabetic (NOD) mice and reduce their diabetes incidence. Methods Five‐week‐…
View article: Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments
Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments Open
View article: Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice
Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice Open
View article: Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice Open
Disturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclea…
View article: High fat diet is associated with gut microbiota dysbiosis and decreased gut microbial derived metabolites related to metabolic health in young Göttingen Minipigs
High fat diet is associated with gut microbiota dysbiosis and decreased gut microbial derived metabolites related to metabolic health in young Göttingen Minipigs Open
The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, and 2) to assess whether ovariectomized female and castrated male minipigs show simil…
View article: Leitfaden zur zuverlässigkeitsbasierten Bewertung bestehender Brücken - Beispiele aus der Praxis
Leitfaden zur zuverlässigkeitsbasierten Bewertung bestehender Brücken - Beispiele aus der Praxis Open
View article: Induction of <scp>CD8</scp><sup>+</sup> immune memory and enhanced inflammation in a skin inflammation model through <scp>pre‐immunization</scp> with inactivated pathogens
Induction of <span>CD8</span><sup>+</sup> immune memory and enhanced inflammation in a skin inflammation model through <span>pre‐immunization</span> with inactivated pathogens Open
Laboratory mice live in specific pathogen‐free (SPF) conditions, resulting in an immature immune system comparable to that of newborns rather than adult humans or mice from pet shops. This condition may compromise their translational value…
View article: Inulin Supplementation Modulates the Hepatic Transcriptome, Metabolome, and Ferritin Content in Ovariectomized Rats
Inulin Supplementation Modulates the Hepatic Transcriptome, Metabolome, and Ferritin Content in Ovariectomized Rats Open
Scope Liver is an important metabolic organ regulating whole‐body homeostasis. This study aims to investigate how prebiotic‐induced changes in the metabolic activity of the gut microbiome (GM) and dietary calcium depletion modulates the he…
View article: Investigating the Rescue Potential of Fecal Microbiota Transplants in Anorexia Nervosa using Antibiotic-treated Mice in a Split Group Cross-Over Study
Investigating the Rescue Potential of Fecal Microbiota Transplants in Anorexia Nervosa using Antibiotic-treated Mice in a Split Group Cross-Over Study Open
Anorexia nervosa (AN) is a complex and serious mental disorder, which may affect individuals of all ages and sex, but primarily affecting young women. The disease is characterized by a disturbed body image, restrictive eating behavior, and…
View article: Investigating the Rescue Potential of Fecal Microbiota Transplants in Anorexia Nervosa using Antibiotic-treated Mice in a Split Group Cross-Over Study
Investigating the Rescue Potential of Fecal Microbiota Transplants in Anorexia Nervosa using Antibiotic-treated Mice in a Split Group Cross-Over Study Open
Anorexia nervosa (AN) is a complex and serious mental disorder, which may affect individuals of all ages and sex, but primarily affecting young women. The disease is characterized by a disturbed body image, restrictive eating behavior, and…
View article: Effect of Systemic Administration of CD4<sup>+</sup> T cells and Local Administration of T-cell Stimulants on T-cell Activity in Psoriatic Skin Xenografts on NOG Mice
Effect of Systemic Administration of CD4<sup>+</sup> T cells and Local Administration of T-cell Stimulants on T-cell Activity in Psoriatic Skin Xenografts on NOG Mice Open
Immunodeficient mice engrafted with psoriatic human skin are widely used for the preclinical evaluation of new drug candidates. However, the T-cell activity, including the IL23/IL17 pathway, declines in the graft over time after engraftmen…
View article: Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome
Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome Open
Background The prevalence of Equine Metabolic Syndrome and insulin dysregulation is increasing in the horse population. Insulin dysregulation is a risk factor for laminitis, which has significant welfare consequences for the horse. Current…
View article: Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition
Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition Open
Inflammatory Bowel Disease (IBD) affects approximately 0.3% of the global population, with incidence rates rising dramatically worldwide. Emerging evidence points to an interplay between exposome factors such as diet and gut microbiota, ho…
View article: Investigating the Crime Scene—Molecular Signatures in Inflammatory Bowel Disease
Investigating the Crime Scene—Molecular Signatures in Inflammatory Bowel Disease Open
Inflammatory bowel diseases (IBD) are without cure and troublesome to manage because of the considerable diversity between patients and the lack of reliable biomarkers. Several studies have demonstrated that diet, gut microbiota, genetics …
View article: Fecal virome transfer improves proliferation of commensal gut <i>Akkermansia muciniphila</i> and unexpectedly enhances the fertility rate in laboratory mice
Fecal virome transfer improves proliferation of commensal gut <i>Akkermansia muciniphila</i> and unexpectedly enhances the fertility rate in laboratory mice Open
Probiotics are intended to improve gastrointestinal health when consumed. However, the probiotics marketed today only colonize the densely populated gut to a limited extent. Bacteriophages comprise the majority of viruses in the human gut …