Axel Seltsam
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View article: International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection
International review of blood donation screening for anti‐HBc and occult hepatitis B virus infection Open
Background Hepatitis B core antibody (anti‐HBc) screening has been implemented in many blood establishments to help prevent transmission of hepatitis B virus (HBV), including from donors with occult HBV infection (OBI). We review HBV scree…
View article: Dose‐dependent inactivation of <i>Plasmodium falciparum</i> in red blood cell concentrates by treatment with short‐wavelength ultraviolet light
Dose‐dependent inactivation of <i>Plasmodium falciparum</i> in red blood cell concentrates by treatment with short‐wavelength ultraviolet light Open
Background and Objectives Plasmodium species are naturally transmitted by Anopheles mosquitos. The parasite infects red blood cells (RBCs) and can be transfused with blood products. In non‐endemic areas, the main risk of infection arises f…
View article: West Nile and Usutu viruses are efficiently inactivated in platelet concentrates by <scp>UVC</scp> light using the <scp>THERAFLEX UV‐Platelets</scp> system
West Nile and Usutu viruses are efficiently inactivated in platelet concentrates by <span>UVC</span> light using the <span>THERAFLEX UV‐Platelets</span> system Open
Background and Objectives West Nile virus (WNV) and Usutu virus (USUV) are mosquito‐borne flaviviruses (Flaviviridae) that originated in Africa, have expanded their geographical range during the last decades and caused documented infection…
View article: Proliferation of psychrotrophic bacteria in cold‐stored platelet concentrates
Proliferation of psychrotrophic bacteria in cold‐stored platelet concentrates Open
Background and Objectives Platelet concentrates (PC) are stored at 20–24°C to maintain platelet functionality, which may promote growth of contaminant bacteria. Alternatively, cold storage of PC limits bacterial growth; however, data relat…
View article: An international review of the characteristics of viral nucleic acid‐amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT
An international review of the characteristics of viral nucleic acid‐amplification testing (NAT) reveals a trend towards the use of smaller pool sizes and individual donation NAT Open
Background and Objectives Nucleic acid‐amplification testing (NAT) is used for screening blood donations/donors for blood‐borne viruses. We reviewed global viral NAT characteristics and NAT‐yield confirmatory testing used by blood operator…
View article: International review of blood donation nucleic acid amplification testing
International review of blood donation nucleic acid amplification testing Open
Background and Objectives Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion‐transmitted infections. This project reviewed NAT for screen…
View article: Novel method for determining when a field‐collected donor unit is sufficiently full
Novel method for determining when a field‐collected donor unit is sufficiently full Open
Background Whole blood (WB) collections can occur downrange for immediate administration. An important aspect of these collections is determining when the unit is sufficiently full. This project tested a novel method for determining when a…
View article: Growth and Distribution of Bacteria in Contaminated Whole Blood and Derived Blood Components
Growth and Distribution of Bacteria in Contaminated Whole Blood and Derived Blood Components Open
Introduction: Bacterial contamination of blood products presumably occurs mainly during blood collection, starting from low initial concentrations of 10–100 colony-forming units (CFUs) per bag. As little is known about bacter…
View article: Inactivation of <scp>SARS‐CoV</scp>‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light
Inactivation of <span>SARS‐CoV</span>‐2 infectivity in platelet concentrates or plasma following treatment with ultraviolet C light or with methylene blue combined with visible light Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is unlikely to be a major transfusion‐transmitted pathogen; however, convalescent plasma is a treatment option used in some regions. The risk of transfusion‐transmitte…
View article: THERAFLEX ultraviolet C (UVC)-based pathogen reduction technology for bacterial inactivation in blood components: advantages and limitations
THERAFLEX ultraviolet C (UVC)-based pathogen reduction technology for bacterial inactivation in blood components: advantages and limitations Open
View article: Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial
Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial Open
Pathogen reduction (PR) technologies for blood components have been established to reduce the residual risk of known and emerging infectious agents. THERAFLEX UVPlatelets, a novel UVC light-based PR technology for platelet concentrates, wo…
View article: Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems
Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems Open
In vitro two-dimensional (2D) and three-dimensional (3D) cultivation of mammalian cells requires supplementation with serum. Mesenchymal stem cells (MSCs) are widely used in clinical trials for bioregenerative medicine and in most cases, i…
View article: Xeno-Free In Vitro Cultivation and Osteogenic Differentiation of hAD-MSCs on Resorbable 3D Printed RESOMER®
Xeno-Free In Vitro Cultivation and Osteogenic Differentiation of hAD-MSCs on Resorbable 3D Printed RESOMER® Open
The development of alloplastic resorbable materials can revolutionize the field of implantation technology in regenerative medicine. Additional opportunities to colonize the three-dimensionally (3D) printed constructs with the patient’s ow…
View article: Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype Open
View article: Inactivation of three emerging viruses – severe acute respiratory syndrome coronavirus, Crimean–Congo haemorrhagic fever virus and Nipah virus – in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light
Inactivation of three emerging viruses – severe acute respiratory syndrome coronavirus, Crimean–Congo haemorrhagic fever virus and Nipah virus – in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light Open
Background Emerging viruses like severe acute respiratory syndrome coronavirus (SARS‐CoV), Crimean–Congo haemorrhagic fever virus (CCHFV) and Nipah virus (NiV) have been identified to pose a potential threat to transfusion safety. In this …
View article: Gelatin-Methacryloyl (GelMA) Formulated with Human Platelet Lysate Supports Mesenchymal Stem Cell Proliferation and Differentiation and Enhances the Hydrogel’s Mechanical Properties
Gelatin-Methacryloyl (GelMA) Formulated with Human Platelet Lysate Supports Mesenchymal Stem Cell Proliferation and Differentiation and Enhances the Hydrogel’s Mechanical Properties Open
Three-dimensional (3D) cell culture is a major focus of current research, since cultivation under physiological conditions provides more reliable information about in vivo cell behavior. 3D cell cultures are used in basic research to bette…
View article: Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively
Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively Open
BACKGROUND Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS‐CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV‐Platelets and THERAFLEX MB‐Plasma…
View article: Beeinflusst eine homozygote Mutation im Semaphorin7a-Gen die subjektive Geschmackswahrnehmung?
Beeinflusst eine homozygote Mutation im Semaphorin7a-Gen die subjektive Geschmackswahrnehmung? Open
Die Gruppe der Semaphorine spielen für eine korrekte Verknüpfung von Geschmackszellen mit geschmacks-spezifischen Ganglionzellen eine entscheidende Rolle. Im Mausmodell konnte gezeigt werden, dass Semaphorin3a (Sema3a, lösliches Protein) f…
View article: Does a homozygous mutation in the Semaphorine7a-gene influence the gustatory function?
Does a homozygous mutation in the Semaphorine7a-gene influence the gustatory function? Open
The group of Semaphorins plays a key-role in wiring taste-receptor-cells to their taste-specific ganglion-cells. In a mouse model Semaphorin3a (Sema3a, soluble) seems to be important to connect “bitter” receptor-cells to their neurons, whi…
View article: Mitochondrial DNA multiplex real‐time polymerase chain reaction inhibition assay for quality control of pathogen inactivation by ultraviolet C light in platelet concentrates
Mitochondrial DNA multiplex real‐time polymerase chain reaction inhibition assay for quality control of pathogen inactivation by ultraviolet C light in platelet concentrates Open
BACKGROUND Several ultraviolet (UV) light‐based pathogen inactivation (PI) technologies for platelet (PLT) products have been developed or are under development. Upon implementation of PI technologies, quality control measures are required…
View article: Pathogen Inactivation of Cellular Blood Products—An Additional Safety Layer in Transfusion Medicine
Pathogen Inactivation of Cellular Blood Products—An Additional Safety Layer in Transfusion Medicine Open
In line with current microbial risk reduction efforts, pathogen inactivation (PI) technologies for blood components promise to reduce the residual risk of known and emerging infectious agents. The implementation of PI of labile blood compo…
View article: Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light
Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light Open
BACKGROUND Zika virus (ZIKV) has emerged as a potential threat to transfusion safety worldwide. Pathogen inactivation is one approach to manage this risk. In this study, the efficacy of the THERAFLEX UV‐Platelets system and THERAFLEX MB‐Pl…
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View article: In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation
In vitro Quality of Platelets with Low Plasma Carryover Treated with Ultraviolet C Light for Pathogen Inactivation Open
Background: The THERAFLEX UV-Platelets system uses shortwave ultraviolet C light (UVC, 254 nm) to inactivate pathogens in platelet components. Plasma carryover influences pathogen inactivation and platelet quality following treatmen…
View article: Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure
Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure Open
The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a…