Axel Steiger
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View article: An increase in C-reactive protein levels during antidepressant treatment predicts treatment non-response in major depressive disorder
An increase in C-reactive protein levels during antidepressant treatment predicts treatment non-response in major depressive disorder Open
Background One-third of patients with major depressive disorder (MDD) exhibit low-grade inflammation as reflected by C-reactive protein (CRP) concentrations > 3 mg/L. We explored whether CRP changes from baseline to week one of antidepress…
View article: Sleep Neurophysiology in Depression
Sleep Neurophysiology in Depression Open
Sleep disturbances are both a primary symptom of and risk factor for major depressive disorder (MDD). Sleep alterations in MDD include the presence of insomnia or hypersomnia and aberrations in sleep macro- and microstructure, including a …
View article: Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles Open
Sleep cycles are defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. Fractal or aperiodic neural activity is a well-established marker of arousal and sleep stages measured using electroencepha…
View article: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles Open
Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functi…
View article: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles Open
Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functi…
View article: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles Open
Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functi…
View article: Author response: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles
Author response: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles Open
Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functi…
View article: Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep, a new aperiodic activity-based definition of sleep cycles Open
Sleep cycles are defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. Fractal or aperiodic neural activity is a well-established marker of arousal and sleep stages measured using electroencepha…
View article: Divergent Associations of Slow‐Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid‐Beta
Divergent Associations of Slow‐Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid‐Beta Open
Objective Recent evidence shows that during slow‐wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid‐beta protein. Poor sleep or elevated cortisol levels can worsen amyloid‐beta clearance, potenti…
View article: Electrophysiological correlates of lucid dreaming: sensor and source level signatures
Electrophysiological correlates of lucid dreaming: sensor and source level signatures Open
Lucid dreaming (LD) is a state of conscious awareness of the current dream state, predominantly associated with REM sleep. Research progress in uncovering the neurobiological basis of LD has been hindered by low sample sizes, diverse EEG s…
View article: Sleep disturbances in primary aldosteronism are associated to depressive symptoms - Could specific mineralocorticoidreceptors be a common pathway?
Sleep disturbances in primary aldosteronism are associated to depressive symptoms - Could specific mineralocorticoidreceptors be a common pathway? Open
Symptoms of depression and anxiety are frequent in patients with primary aldosteronism (PA) and are supposed to be independent risk factors for cardiovascular diseases (CVD). As patients with PA have an increased cardiovascular risk compar…
View article: Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles
Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles Open
Nocturnal human sleep consists of 4 – 6 ninety-minute cycles defined as episodes of non-rapid eye movement (non-REM) sleep followed by an episode of REM sleep. While sleep cycles are considered fundamental components of sleep, their functi…
View article: Sustained polyphasic sleep restriction abolishes human growth hormone release
Sustained polyphasic sleep restriction abolishes human growth hormone release Open
Voluntary sleep restriction is a common phenomenon in industrialized societies aiming to increase time spent awake and thus productivity. We explored how restricting sleep to a radically polyphasic schedule affects neural, cognitive, and e…
View article: Divergent associations of slow-wave sleep vs. REM sleep with plasma amyloid-beta
Divergent associations of slow-wave sleep vs. REM sleep with plasma amyloid-beta Open
Background Recent evidence shows that during slow-wave sleep (SWS), the brain is cleared from potentially toxic metabolites, such as the amyloid-beta protein. Poor sleep or elevated cortisol levels can worsen amyloid-beta clearance, potent…
View article: Increased aperiodic neural activity during sleep in major depressive disorder
Increased aperiodic neural activity during sleep in major depressive disorder Open
Background In major depressive disorder (MDD), patients often express subjective sleep complaints while polysomnographic studies report only subtle alterations in neural oscillations. We hypothesize that the study of aperiodic electroencep…
View article: Non-REM sleep in major depressive disorder
Non-REM sleep in major depressive disorder Open
Disturbed sleep is a key symptom in major depressive disorder (MDD). REM sleep alterations are well described in the current literature, but little is known about non-REM sleep alterations. Additionally, sleep disturbances relate to a vari…
View article: Non-REM sleep in major depressive disorder
Non-REM sleep in major depressive disorder Open
Disturbed sleep is a key symptom in major depressive disorder (MDD). REM sleep alterations are well described in the current fliterature, but little is known about non-REM sleep alterations. Additionally, sleep disturbances relate to a var…
View article: Durable memories and efficient neural coding through mnemonic training using the method of loci
Durable memories and efficient neural coding through mnemonic training using the method of loci Open
Mnemonic training boosts long-lasting memories, supported by optimized brain processing and consolidation.
View article: Sleep fragmentation and lucid dreaming
Sleep fragmentation and lucid dreaming Open
Lucid dreaming-the phenomenon of experiencing waking levels of self-reflection within one's dreams-is associated with more wake-like levels of neural activation in prefrontal brain regions. In addition, alternating periods of wakefulness a…
View article: Durable memories and efficient neural coding through mnemonic training using the method of loci
Durable memories and efficient neural coding through mnemonic training using the method of loci Open
Mnemonic techniques, such as the method of loci, can powerfully boost memory. Here, we compared memory athletes ranked among the world’s top 50 in memory sports to mnemonics-naïve controls. In a second study, participants completed a six-w…
View article: A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum
A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum Open
A novel method for deriving composite, non-redundant measures of non-rapid eye movement (NREM) sleep electroencephalogram (EEG) is developed on the basis of the power law scaling of the Fourier spectra. Measures derived are the spectral in…
View article: Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism
Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism Open
Primary aldosteronism is a natural model for chronic aldosterone excess in humans and associated with symptoms of anxiety and depression. Cognitive deficits are inherent to the symptomatology of depression and anxiety disorders. Mineraloco…
View article: Depression and Sleep
Depression and Sleep Open
Impaired sleep is both a risk factor and a symptom of depression. Objective sleep is assessed using the sleep electroencephalogram (EEG). Characteristic sleep-EEG changes in patients with depression include disinhibition of rapid eye movem…