Aya Naiki‐Ito
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View article: Use of the TIPS Technique as a Possible Method of Acute Inhalation Toxicity Assessment
Use of the TIPS Technique as a Possible Method of Acute Inhalation Toxicity Assessment Open
Acute inhalation toxicity studies provide crucial information regarding short‐term exposure to volatile chemicals and help to ensure the safe handling and use of these chemicals. However, acute inhalation toxicity assessment requires speci…
View article: Comparative Carcinogenicity of Double-Walled Carbon Nanotubes of Different Lengths Administered by Intratracheal Installation into Rat Lungs
Comparative Carcinogenicity of Double-Walled Carbon Nanotubes of Different Lengths Administered by Intratracheal Installation into Rat Lungs Open
We previously carried out an in vivo 2-year study to assess the potential toxicity/carcinogenicity of double-walled carbon nanotubes (DWCNTs) in a rat lung. We found that administration of DWCNTs by intratracheal–intrapulmonary spraying (T…
View article: Efficacy and safety of anamorelin in patients with metastatic urothelial carcinoma receiving systemic chemotherapy: a randomized controlled study
Efficacy and safety of anamorelin in patients with metastatic urothelial carcinoma receiving systemic chemotherapy: a randomized controlled study Open
Background Cancer cachexia reduces chemotherapy efficacy in patients with metastatic urothelial carcinoma (mUC). Anamorelin improves cancer cachexia by increasing serum insulin-like growth factor 1 (IGF-1). The aim of this study was to eva…
View article: Efficacy of prostatectomy using a Retzius‐sparing approach as an additional excision in anal canal carcinoma after brachytherapy for prostate adenocarcinoma
Efficacy of prostatectomy using a Retzius‐sparing approach as an additional excision in anal canal carcinoma after brachytherapy for prostate adenocarcinoma Open
Introduction Standard treatments for squamous cell carcinoma of the anal canal include chemoradiotherapy and surgical resection. We report a rare case of squamous cell carcinoma of the anal canal with prostate invasion treated with curativ…
View article: A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung
A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung Open
The carcinogenic potential of MWCNTs is not well defined. Currently, IARC has classified MWCNT-7 as a Group 2 B material, possibly carcinogenic to humans, and all other MWCNTs as Group 3 materials, inadequate evidence in experimental anima…
View article: Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research
Exploring experimental models of prostate cancer in chemoprevention: Oxidative stress as a key pathway to translational research Open
Prostate cancer (PCa) is the second most common cancer in men globally. Its growth is driven by oxidative stress associated with inflammation, aging, and environmental factors, including diet and lifestyle. These factors contribute to mult…
View article: Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer
Supplementary Data from Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer Open
Figure S1-S8 & Table S1-S6
View article: Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveillance
Preliminary Evidence on Safety and Clinical Efficacy of Luteolin for Patients With Prostate Cancer Under Active Surveillance Open
Background: A need exists for effective treatments for prostate cancer (PCA) due its re‐emergence following androgen deprivation therapy, a major clinical problem. In a previous study, we presented evidence on the chemopreventive and chemo…
View article: Efficacy of pembrolizumab plus lenvatinib as first‐line treatment for metastatic renal cell carcinoma with multiple brain metastases
Efficacy of pembrolizumab plus lenvatinib as first‐line treatment for metastatic renal cell carcinoma with multiple brain metastases Open
Introduction Patients with metastatic renal cell carcinoma have a poor prognosis and its specific pathogenesis remains unelucidated. Case presentation At 78 years of age, a Japanese male patient was diagnosed with metastatic renal cell car…
View article: The role of <scp>DPYD</scp> and the effects of <scp>DPYD</scp> suppressor luteolin combined with 5‐<scp>FU</scp> in pancreatic cancer
The role of <span>DPYD</span> and the effects of <span>DPYD</span> suppressor luteolin combined with 5‐<span>FU</span> in pancreatic cancer Open
Background Despite advances in the treatment of cancer, pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to the lack of effective therapies. Our previous study showed that Luteolin (Lut), a flavonoid, suppressed pancreatoc…
View article: C-Reactive Protein Is a Potential Prognostic Marker in Patient with Advanced or Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multi-Center Retrospective Study
C-Reactive Protein Is a Potential Prognostic Marker in Patient with Advanced or Metastatic Urothelial Carcinoma Treated with Enfortumab Vedotin: A Multi-Center Retrospective Study Open
Background: In the EV-301 trial, enfortumab vedotin prolonged survival in patients with locally advanced or metastatic urothelial carcinoma previously treated with platinum-based therapy and programmed cell death 1/programmed death-ligand …
View article: Hexane insoluble fraction from purple rice extract improves steatohepatitis and fibrosis <i>via</i> inhibition of NF-κB and JNK signaling
Hexane insoluble fraction from purple rice extract improves steatohepatitis and fibrosis <i>via</i> inhibition of NF-κB and JNK signaling Open
Inhibition of NF-κB and JNK signaling by PRE-HIF contributes to decreased expression of cytokines and improved histological changes in NASH.
View article: Incidence of Pancreatic Injury and Pancreatitis in Patients Treated With Immune Checkpoint Inhibitors
Incidence of Pancreatic Injury and Pancreatitis in Patients Treated With Immune Checkpoint Inhibitors Open
INTRODUCTION: Immune checkpoint inhibitors (ICIs) are being increasingly used to treat advanced malignancies. ICI-induced pancreatic injury (ICI-PI), which is an immune-related adverse event that may be a risk factor of ICI-associated panc…
View article: Successful treatment with enfortumab–vedotin of metastatic signet ring cell cancer expressing nectin‐4 and originating from the bladder
Successful treatment with enfortumab–vedotin of metastatic signet ring cell cancer expressing nectin‐4 and originating from the bladder Open
Introduction As an aggressive adenocarcinoma phenotype, primary signet ring cell carcinoma of the urinary bladder is an extremely rare variant. The prognosis of metastatic signet ring cell carcinoma of the urinary bladder is extremely poor…
View article: Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy‐epispadias complex
Urothelial carcinoma occurring in a defunctionalized bladder after urinary diversion due to the bladder exstrophy‐epispadias complex Open
Introduction The bladder exstrophy‐epispadias complex is a rare congenital disease. Urothelial carcinomas rarely occur in patients with this disease, and there have been few reports on its treatment. Case presentation We report the case of…
View article: The prognostic efficacy of a sustainable geriatric nutritional risk index for avelumab switch maintenance therapy in metastatic urothelial carcinoma
The prognostic efficacy of a sustainable geriatric nutritional risk index for avelumab switch maintenance therapy in metastatic urothelial carcinoma Open
Background Metastatic urothelial carcinoma (mUC) has a poor prognosis. Avelumab is approved for mUC maintenance therapy and prolongs overall survival. However, real-world data, including the prognostic analysis of maintenance therapy, is l…
View article: Supplementary Figure Legends from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure Legends from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Supplementary Figure S1: Cell viability in pancreatic cancer cells treated by talaporfin with or without irradiation. Supplementary Figure S2: The luciferase luminescence intensities in AsPC1/luc cells treated by PDT with talaporfin or Mal…
View article: Supplementary Figure S2 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S2 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
The luciferase luminescence intensities in AsPC1/luc cells treated by PDT with talaporfin or Mal3-chlorin.
View article: Supplementary Figure S3 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S3 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Average body weight transitions of mice during the experiment.
View article: Supplementary Figure S5 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S5 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Involvement of GLUT1 in the uptake of Mal3-chlorin into pancreatic cancer cells.
View article: Supplementary Figure Legends from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure Legends from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Supplementary Figure S1: Cell viability in pancreatic cancer cells treated by talaporfin with or without irradiation. Supplementary Figure S2: The luciferase luminescence intensities in AsPC1/luc cells treated by PDT with talaporfin or Mal…
View article: Supplementary Figure S2 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S2 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
The luciferase luminescence intensities in AsPC1/luc cells treated by PDT with talaporfin or Mal3-chlorin.
View article: Supplementary Figure S4 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S4 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Images of representative abdominal skin of mice from each group.
View article: Supplementary Figure S3 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S3 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Average body weight transitions of mice during the experiment.
View article: Supplementary Figure S6 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S6 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Correlation between the fluorescence intensities and the dose of Mal3-chlorin or the number of cells.
View article: Supplementary Figure S1 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S1 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Cell viability in pancreatic cancer cells treated by talaporfin with or without irradiation.
View article: Supplementary Figure S4 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S4 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Images of representative abdominal skin of mice from each group.
View article: Supplementary Figure S6 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer
Supplementary Figure S6 from Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer Open
Correlation between the fluorescence intensities and the dose of Mal3-chlorin or the number of cells.