Aya Mawatari
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View article: Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats
Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats Open
Introduction A series of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infectio…
View article: Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors
Chemogenetic activation of target neurons expressing insect Ionotropic Receptors in the mammalian central nervous system by systemic administration of ligand precursors Open
The IR-mediated neuronal activation (IRNA) technology allows stimulation of neurons in the brain that heterologously-express members of the insect chemosensory IR repertoire in response to their cognate ligands. In the current protocol, a …
View article: In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters Open
Background ( S )-2-amino-3-[3-(2- 18 F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid ( 18 F-FIMP) as a promising PET probe for imaging the tumor-specific L-type amino acid transporter (LAT) 1. Our previous study revealed that 18 F-FIM…
View article: Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response
Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response Open
Several limitations of [ 18 F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [ 11 C]MET has been found to accumulate in normal and inflammatory tissues as well as tumors. To increase specificity to tumor…
View article: Synthesis and Preclinical Evaluation of <sup>18</sup>F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation.
Synthesis and Preclinical Evaluation of <sup>18</sup>F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation. Open
Cyclooxygenase (COX) is a rate-limiting enzyme in the synthesis of proinflammatory prostanoids from arachidonic acid. In vivo imaging of COX by PET is a potentially powerful tool for assessing the inflammatory response to injury, infection…
View article: Regional neuroinflammation caused by peripheral infection is involved in fatigued symptoms: A [18F]DPA-714 PET study
Regional neuroinflammation caused by peripheral infection is involved in fatigued symptoms: A [18F]DPA-714 PET study Open
A s eries of symptoms, including fever, widespread pain, fatigue, and even ageusia, have frequently been reported in the context of various infections, such as COVID-19. Although the pathogenic mechanisms underlying an infection causing fe…
View article: [18F]DPA-714 PET Imaging for the Quantitative Evaluation of Early Spatiotemporal Changes of Neuroinflammation in Rat Brain Following Status Epilepticus
[18F]DPA-714 PET Imaging for the Quantitative Evaluation of Early Spatiotemporal Changes of Neuroinflammation in Rat Brain Following Status Epilepticus Open
Background Most antiepileptic drug therapies are symptomatic and adversely suppress normal brain function by nonspecific inhibition of neuronal activity. In recent times, growing evidence has suggested that neuroinflammation triggered by e…
View article: Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation
Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation Open
We previously identified a novel mutation in amyloid precursor protein from a Japanese pedigree of familial Alzheimer’s disease, FAD (Osaka). Our previous positron emission tomography (PET) study revealed that amyloid β (Aβ) accumulation w…
View article: 18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation
18F-FIMP: a LAT1-specific PET probe for discrimination between tumor tissue and inflammation Open
Positron emission tomography (PET) imaging can assist in the early-phase diagnostic and therapeutic evaluation of tumors. Here, we report the radiosynthesis, small animal PET imaging, and biological evaluation of a L-type amino acid transp…
View article: Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes
Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes Open
Background: We previously reported that among cases clinically diagnosed with Alzheimer’s disease, the proportion of amyloid beta (Aβ) -negative case increases in the elderly population. Tauopathy including Argyrophilic Grain Disease (AGD)…
View article: MHC matching improves engraftment of iPSC-derived neurons in non-human primates
MHC matching improves engraftment of iPSC-derived neurons in non-human primates Open
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy…
View article: Localized Accumulation of Tau without Amyloid-Beta in Aged Brains Measured with [11C]PBB3 and [11C]Pib Positron Emission Tomography
Localized Accumulation of Tau without Amyloid-Beta in Aged Brains Measured with [11C]PBB3 and [11C]Pib Positron Emission Tomography Open
Objective: Different regional specificity in tau accumulation is well known in Alzheimer's disease (AD) brains. However, little is known about such distribution in aging brains and mild cognitive impairment (MCI) brains. Methods: Cognitive…
View article: Marmoset Serotonin 5-HT<sub>1A</sub>Receptor Mapping with a Biased Agonist PET Probe<sup>18</sup>F-F13714: Comparison with an Antagonist Tracer<sup>18</sup>F-MPPF in Awake and Anesthetized States
Marmoset Serotonin 5-HT<sub>1A</sub>Receptor Mapping with a Biased Agonist PET Probe<sup>18</sup>F-F13714: Comparison with an Antagonist Tracer<sup>18</sup>F-MPPF in Awake and Anesthetized States Open
These findings highlight the importance of investigating the brain imaging of serotonin 1A receptors using agonist probes such as 18F-F13714, which may preferentially target subpopulations of serotonin 1A receptors in specific brain region…
View article: Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer’s Disease Model Mice
Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer’s Disease Model Mice Open
(S)-(11)C-KTP-Me is a potent PET probe that is highly selective for COX-1. Studies using APP-Tg mice demonstrated that (S)-(11)C-KTP-Me could detect activated microglia that are associated with amyloid plaque progression, suggesting the in…