Aya Takahashi
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View article: Highly contiguous assemblies of 101 drosophilid genomes
Highly contiguous assemblies of 101 drosophilid genomes Open
Over 100 years of studies in Drosophila melanogaster and related species in the genus Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high-quality genome assemblies exist for severa…
View article: Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids
Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids Open
Behaviors are among the first traits to evolve as animals enter new niches, but their molecular bases are poorly understood. To address this gap, we used the mustard-feeding drosophilid fly Scaptomyza flava , which feeds on toxic Brassical…
View article: Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in <i>Drosophila</i>
Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in <i>Drosophila</i> Open
Manipulating gene expression in a tissue-specific and temporally controlled manner is essential for understanding the function of the focal genes. Still, in many cases, the limited availability of specific promotors to drive ectopic manipu…
View article: Characterization of Beverage Viscosity Based on the International Dysphagia Diet Standardisation Initiative and Its Correspondence to the Japanese Dysphagia Diet 2021
Characterization of Beverage Viscosity Based on the International Dysphagia Diet Standardisation Initiative and Its Correspondence to the Japanese Dysphagia Diet 2021 Open
Background/Objective: The International Dysphagia Diet Standardisation Initiative (IDDSI) and the Japanese Dysphagia Diet 2021 (JDD2021) are prominent systems that classify thickened beverages for dysphagia management. We herein aim to est…
View article: Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life
Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life Open
Long-read sequencing is driving rapid progress in genome assembly : across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a co…
View article: Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life
Single-fly genome assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life Open
Long-read sequencing is driving rapid progress in genome assembly across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost…
View article: A case of intestinal myiasis in a bedridden elderly patient
A case of intestinal myiasis in a bedridden elderly patient Open
症例は75歳男性.既往歴は2型糖尿病,膿胸術後など.慢性肺疾患による活動性低下で体動困難となり当院救急搬送され脱水症で入院となった.入院後2日間においてオムツ内に数匹の虫体が確認された.検査結果はハエの幼虫であり,消化器ハエ症と診断した.ハエの幼虫が確認できなくなった後で発熱あり,二次感染と考え抗菌薬投与を行い改善した.後日家族が自宅の掃除を行ったが,ハエやハエの幼虫は発見できず感染経路やハエ種は明らかにならなかった.ハエ症は衛生状態が良好になるにつれ報告数が減少したといわ…
View article: Effect of acetic acid bacteria colonization on oviposition and feeding site choice in Drosophila suzukii and its related species
Effect of acetic acid bacteria colonization on oviposition and feeding site choice in Drosophila suzukii and its related species Open
Unlike many species of Drosophila flies that colonize decaying fruits, Drosophila suzukii lay eggs in ripening fruits. The oviposition and feeding site preferences for bacterial growth were quantified in multiple strains of <…
View article: Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life
Single-fly assemblies fill major phylogenomic gaps across the Drosophilidae Tree of Life Open
Long-read sequencing is driving rapid progress in genome assembly across all major groups of life, including species of the family Drosophilidae, a longtime model system for genetics, genomics, and evolution. We previously developed a cost…
View article: Thermal plasticity of wing size and wing spot size in Drosophila guttifera
Thermal plasticity of wing size and wing spot size in Drosophila guttifera Open
Thermal plasticity of melanin pigmentation patterns in Drosophila species has been studied as a model to investigate developmental mechanisms of phenotypic plasticity. The developmental process of melanin pigmentation patterns on wings of …
View article: Image sharpening algorithms improve clarity of surgical field during 3D heads-up surgery
Image sharpening algorithms improve clarity of surgical field during 3D heads-up surgery Open
Background Image-sharpening algorithms with color adjustments enable real-time processing of the surgical field with a delay of 4 msec for heads-up surgery using digital three-dimensional displays. The aim of this study was to investigate …
View article: Effect of acetic acid bacteria colonization on oviposition and feeding site choice in<i>Drosophila suzukii</i>and its related species
Effect of acetic acid bacteria colonization on oviposition and feeding site choice in<i>Drosophila suzukii</i>and its related species Open
Oviposition site choice has a large impact on offspring performance. Unlike other vinegar flies that colonize decaying fruits, Drosophila suzukii lay eggs into hard ripening fruits by using their enlarged and serrated ovipositors (oviscapt…
View article: Effect of the COVID-19 Pandemic on Surgical Outcomes for Rhegmatogenous Retinal Detachments
Effect of the COVID-19 Pandemic on Surgical Outcomes for Rhegmatogenous Retinal Detachments Open
We reviewed the medical records of 438 eyes in 431 patients who had undergone surgeries for rhegmatogenous retinal detachments (RRD) or proliferative vitreoretinopathy (PVR ≥ Grade C) to determine whether the COVID-19 pandemic had affected…
View article: Thermal plasticity of wing spot size in<i>Drosophila guttifera</i>: investigating the relevance to Wingless morphogen
Thermal plasticity of wing spot size in<i>Drosophila guttifera</i>: investigating the relevance to Wingless morphogen Open
Thermal plasticity of animal color patterns has been studied to investigate the molecular mechanisms of phenotypic plasticity. There are examples in which the formation of color patterns is controlled by a morphogen. The extracellular dist…
View article: Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species
Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species Open
View article: A standardized nomenclature and atlas of the female terminalia of <i>Drosophila melanogaster</i>
A standardized nomenclature and atlas of the female terminalia of <i>Drosophila melanogaster</i> Open
The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous pa…
View article: Qualitative study of process in daily life of patients with larynx/pharyngeal cancer before total laryngectomy
Qualitative study of process in daily life of patients with larynx/pharyngeal cancer before total laryngectomy Open
Background: Many patients with larynx/pharyngeal cancer only become aware of the disease in an advanced stage due to hoarseness and a strange feeling upon swallowing. The aim of this study was to discuss what kinds of support are required …
View article: Massive eosinophilia despite severe aplastic anemia
Massive eosinophilia despite severe aplastic anemia Open
A 47-year-old nonsmoking man developed very severe aplastic anemia (AA) (hemoglobin 56 g/L, neutrophils 110/μl, eosinophils 0/μl, platelets 4000/μl) with fatty marrow (Figure 1A: hematoxylin–eosin stain, ×4 objective). He had a history of …
View article: Correction: Highly contiguous assemblies of 101 drosophilid genomes
Correction: Highly contiguous assemblies of 101 drosophilid genomes Open
View article: A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em>
A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em> Open
The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper out…
View article: A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em>
A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em> Open
The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper out…
View article: Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in <i>Drosophila suzukii</i> and its related species
Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in <i>Drosophila suzukii</i> and its related species Open
Background The ovipositors of some insects are external female genitalia, which have their primary function to deliver eggs. Drosophila suzukii and its sibling species D. subpulchrella are known to have acquired highly sclerotized and enla…
View article: A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em>
A Standardized Nomenclature and Atlas of the Female Terminalia of <em>Drosophila melanogaster</em> Open
The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper out…
View article: The role of the epidermis enhancer element in positive and negative transcriptional regulation of <i>ebony</i> in <i>Drosophila melanogaster</i>
The role of the epidermis enhancer element in positive and negative transcriptional regulation of <i>ebony</i> in <i>Drosophila melanogaster</i> Open
The spatiotemporal regulation of gene expression is essential to ensure robust phenotypic outcomes. Pigmentation patterns in Drosophila are determined by pigments biosynthesized in the developing epidermis and the cis-regulatory elements o…
View article: Additional file 2 of Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species
Additional file 2 of Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species Open
Additional file 2: Table S1. Mapping results of RNA-seq using D. suzukii and D. subpulchrella female terminalia at 48 h APF. Table S2. Differentially expressed genes between D. suzukii and D. subpulchrella female terminalia at 48 h APF.
View article: Additional file 3 of Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species
Additional file 3 of Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species Open
Additional file 3. Reciprocally re-annotated CDS. The .zip folder containing reciprocally re-annotated reference CDS used for mapping D. suzukii and D. subpulchrella RNA-seq reads.
View article: Wing size and wing spot size of Drosophila guttifera
Wing size and wing spot size of Drosophila guttifera Open
This data set shows wing size and wing spot size of Drosophila guttifera. We reared the flies under different temperature conditions and tested if wing size and spot size exhibit thermal plasticity. Not only we measured the absolu…
View article: Evolution of Survival Impact of Molecular Target Agents in Patients with Advanced Hepatocellular Carcinoma
Evolution of Survival Impact of Molecular Target Agents in Patients with Advanced Hepatocellular Carcinoma Open
Background and Aims: The prognosis of patients with advanced hepatocellular carcinoma (HCC) is expected to improve as multiple molecular target agents (MTAs) are now available. However, the impact of the availability of seque…
View article: Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress
Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress Open
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. HCC cells consume large amounts of glutamine to survive, but can adapt to glutamine depletion in the presence of an exogenous asparagine. L-asparaginase (ASNas…
View article: The two faces of mast cells in vitiligo pathogenesis
The two faces of mast cells in vitiligo pathogenesis Open
Aim: Previously, we reported increased number of T helper 17 (Th17) cells in vitiligo. However, in our recent study, tryptase and interleukin (IL)17 double positive cells which identified by polyclonal anti-IL17 antibody with specificity f…