Aya Takesono
YOU?
Author Swipe
View article: Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish
Evaluating anaesthetics for improving scientific research and welfare using larval zebrafish Open
Establishing anaesthesia for ensuring both animal welfare and compatibility with protocols required for different areas of scientific research is vital. Zebrafish ( Danio rerio ) are one of the most used animal models in research; however,…
View article: Advancing technical understanding of the double-seeded gill cell culture system for drug uptake studies in fish
Advancing technical understanding of the double-seeded gill cell culture system for drug uptake studies in fish Open
Environmental risk assessment (ERA) is required for new drug approvals in Europe and the United States, driving the demand for reliable bioassays to model active pharmaceutical ingredient (API) uptake in fish. The rainbow trout (Oncorhynch…
View article: Zinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafish
Zinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafish Open
View article: Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development
Application of Transgenic Zebrafish Models for Studying the Effects of Estrogenic Endocrine Disrupting Chemicals on Embryonic Brain Development Open
Endocrine disrupting chemicals (EDCs) are environmental pollutants that mimic hormones and/or disrupt their function. Estrogenic EDCs (eEDCs) interfere with endogenous estrogen signalling pathway(s) and laboratory animal and human epidemio…
View article: Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia
Estrogens regulate early embryonic development of the olfactory sensory system via estrogen-responsive glia Open
Estrogens are well-known to regulate development of sexual dimorphism of the brain; however, their role in embryonic brain development prior to sex-differentiation is unclear. Using estrogen biosensor zebrafish models, we found that estrog…
View article: Estrogen regulates early embryonic development of the olfactory sensory system via estrogen-responsive glia
Estrogen regulates early embryonic development of the olfactory sensory system via estrogen-responsive glia Open
Summary Estrogen is well-known to regulate development of sexual dimorphisms of the brain, however its role in the brain during early embryonic development prior to sex-differentiation is unclear. Using estrogen biosensor zebrafish models,…
View article: Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms
Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms Open
Background and Purpose Functional brain imaging using genetically encoded Ca 2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have b…
View article: New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish
New insights into organ-specific oxidative stress mechanisms using a novel biosensor zebrafish Open
View article: Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish
Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish Open
Estrogen plays fundamental roles in a range of developmental processes and exposure to estrogen mimicking chemicals has been associated with various adverse health effects in both wildlife and human populations. Estrogenic chemicals are fo…