Aya Watanabe
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View article: Effects of Providing Information through an Enhanced Collaborative Model Care Fee and Anticancer Agent Use Follow-up Sheet on Patient Follow-up by Community Pharmacists
Effects of Providing Information through an Enhanced Collaborative Model Care Fee and Anticancer Agent Use Follow-up Sheet on Patient Follow-up by Community Pharmacists Open
View article: Arrival time mapping with 15O-gas PET for cerebrovascular steno-occlusive diseases: a comparative study with CT perfusion
Arrival time mapping with 15O-gas PET for cerebrovascular steno-occlusive diseases: a comparative study with CT perfusion Open
The present method generates arrival-time maps with 15O-gas PET by applying optimized kinetic analysis to dynamic [15O]-CO2 images acquired using a state-of-the-art, high-sensitivity clinical PET scanner. A…
View article: Who Finds This Voice Attractive? A Large-Scale Experiment Using In-the-Wild Data
Who Finds This Voice Attractive? A Large-Scale Experiment Using In-the-Wild Data Open
This paper introduces CocoNut-Humoresque, an open-source large-scale speech likability corpus that includes speech segments and their per-listener likability scores. Evaluating voice likability is essential to designing preferable voices f…
View article: Fatal Myocarditis in Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Without Mortality-Related Risk Factors: A Case Report and Literature Review
Fatal Myocarditis in Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Without Mortality-Related Risk Factors: A Case Report and Literature Review Open
View article: Building speech corpus with diverse voice characteristics for its prompt-based representation
Building speech corpus with diverse voice characteristics for its prompt-based representation Open
In text-to-speech synthesis, the ability to control voice characteristics is vital for various applications. By leveraging thriving text prompt-based generation techniques, it should be possible to enhance the nuanced control of voice char…
View article: Erratum to "Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers" [Biomol Ther 28(4), 311-319 (2020)]
Erratum to "Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers" [Biomol Ther 28(4), 311-319 (2020)] Open
Mahmoud Kandeel, Mizuki Yamamoto, Abdulla Al-Taher, Aya Watanabe, Kentaro Oh-hashi, Byoung Kwon Park, Hyung-Joo Kwon, Jun-ichiro Inoue and Mohammed Al-Nazawi. Biomolecules & Therapeutics 2024;32:262-5. https://doi.org/10.4062/biomolther.20…
View article: Significance of Serum Leucine-rich Alpha-2 Glycoprotein as a Diagnostic Marker in Pediatric Inflammatory Bowel Disease.
Significance of Serum Leucine-rich Alpha-2 Glycoprotein as a Diagnostic Marker in Pediatric Inflammatory Bowel Disease. Open
Serum leucine-rich alpha-2 glycoprotein (LRG) has been utilized for adult inflammatory bowel disease (IBD); however, its efficacy in pediatric IBD remains unknown. The aim of this study was to compare the diagnostic accuracy of serum LRG f…
View article: Coco-Nut: Corpus of Japanese Utterance and Voice Characteristics Description for Prompt-based Control
Coco-Nut: Corpus of Japanese Utterance and Voice Characteristics Description for Prompt-based Control Open
In text-to-speech, controlling voice characteristics is important in achieving various-purpose speech synthesis. Considering the success of text-conditioned generation, such as text-to-image, free-form text instruction should be useful for…
View article: The Organization Process of Legitimate Pedagogic Practices in Schools:
The Organization Process of Legitimate Pedagogic Practices in Schools: Open
View article: A Cell Tracking Method for Dynamic Analysis of Immune Cells Based on Deep Learning
A Cell Tracking Method for Dynamic Analysis of Immune Cells Based on Deep Learning Open
Since the dynamics of immune cells change about phenomena in a living body, it is very important to observe and analyze cell dynamics in vivo in real-time.For this purpose, it is necessary to extract the information for the analysis by acc…
View article: Impact of peritoneal lavage temperature during laparotomy in a preterm peritonitis mouse model using cecal slurry
Impact of peritoneal lavage temperature during laparotomy in a preterm peritonitis mouse model using cecal slurry Open
Background: Peritoneal lavage (PL) during laparotomy is a treatment option for preterm bacterial peritonitis; however, its efficacy remains controversial. We investigated the effects of PL temperature during laparotomy on survival in a cec…
View article: Dienogest Use for Recurrent Pyosalpinx as a Long-Term Complication of Cloacal Exstrophy: A Case Report
Dienogest Use for Recurrent Pyosalpinx as a Long-Term Complication of Cloacal Exstrophy: A Case Report Open
View article: Antiviral medications for mild-to-moderate COVID-19 in Japan: a gap of timing between clinical trials and real-world scenarios in a fast-changing pandemic
Antiviral medications for mild-to-moderate COVID-19 in Japan: a gap of timing between clinical trials and real-world scenarios in a fast-changing pandemic Open
The rapid spread of a novel type of coronavirus infection, coronavirus disease 2019 (COVID-19) has made it difficult to implement the results of clinical trials in real-world situations. After the emergence of the Omicron variant and messe…
View article: Recent Relative Sea‐Level Changes Recorded by Coral Microatolls in Southern Ryukyus Islands, Japan: Implication for the Seismic Cycle of the Megathrust
Recent Relative Sea‐Level Changes Recorded by Coral Microatolls in Southern Ryukyus Islands, Japan: Implication for the Seismic Cycle of the Megathrust Open
The seismic hazard related to megathrust earthquakes in the Ryukyus (southern Japan) is poorly constrained as no large earthquake has been reported there. The Meiwa tsunami impacted the coasts of the Yaeyama and Miyako islands in 1771 but …
View article: Mid-attribute speaker generation using optimal-transport-based interpolation of Gaussian mixture models
Mid-attribute speaker generation using optimal-transport-based interpolation of Gaussian mixture models Open
In this paper, we propose a method for intermediating multiple speakers' attributes and diversifying their voice characteristics in ``speaker generation,'' an emerging task that aims to synthesize a nonexistent speaker's naturally sounding…
View article: A primary appendiceal Burkitt lymphoma mimicking appendiceal abscess
A primary appendiceal Burkitt lymphoma mimicking appendiceal abscess Open
View article: Discovery of New Potent anti-MERS CoV Fusion Inhibitors
Discovery of New Potent anti-MERS CoV Fusion Inhibitors Open
Middle East respiratory syndrome coronavirus (MERS-CoV), capable of zoonotic transmission, has been associated with emerging viral pneumonia in humans. In this study, a set of highly potent peptides were designed to prevent MERS-CoV fusion…
View article: Relationship Between Fundamental Daily Living Habits and Health Literacy Exhibited by Self-Care Behavior in Sixth-Grade Students of Japanese Elementary Schools
Relationship Between Fundamental Daily Living Habits and Health Literacy Exhibited by Self-Care Behavior in Sixth-Grade Students of Japanese Elementary Schools Open
Background: The purpose of this study is to elucidate the relationship between fundamental daily living habits and health literacy exhibited by self-care behaviour in sixth-grade students in Japanese elementary schools by verifying the ass…
View article: Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports
Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports Open
We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administere…
View article: Shallow NV centers augmented by exploiting n-type diamond
Shallow NV centers augmented by exploiting n-type diamond Open
View article: The Combined Effects of Magnesium Oxide and Inulin on Intestinal Microbiota and Cecal Short-Chain Fatty Acids
The Combined Effects of Magnesium Oxide and Inulin on Intestinal Microbiota and Cecal Short-Chain Fatty Acids Open
Constipation is a common condition that occurs in many people worldwide. While magnesium oxide (MgO) is often used as the first-line drug for chronic constipation in Japan, dietary fiber intake is also recommended. Dietary fiber is ferment…
View article: Involvement of Body Temperature Increase and Sympathetic Nerve Activation in Exercise-Induced Microbiota Changes in Mice
Involvement of Body Temperature Increase and Sympathetic Nerve Activation in Exercise-Induced Microbiota Changes in Mice Open
View article: The Antimalarial Compound Atovaquone Inhibits Zika and Dengue Virus Infection by Blocking E Protein-Mediated Membrane Fusion
The Antimalarial Compound Atovaquone Inhibits Zika and Dengue Virus Infection by Blocking E Protein-Mediated Membrane Fusion Open
Flaviviruses bear class II fusion proteins as their envelope (E) proteins. Here, we describe the development of an in vitro quantitative mosquito-cell-based membrane-fusion assay for the E protein using dual split proteins (DSPs). The assa…
View article: Combinatorial Effects of Soluble, Insoluble, and Organic Extracts from Jerusalem Artichokes on Gut Microbiota in Mice
Combinatorial Effects of Soluble, Insoluble, and Organic Extracts from Jerusalem Artichokes on Gut Microbiota in Mice Open
Jerusalem artichokes contain high amounts of inulin, which is a prebiotic that supports digestive health, as well as a variety of insoluble fibers and caffeoylquinic acid. The individual impact of these components on gut microbiota is well…
View article: Suppressed Cellular Proliferation During Postnatal Lung Development in Murine Model of BPD
Suppressed Cellular Proliferation During Postnatal Lung Development in Murine Model of BPD Open
View article: Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers
Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers Open
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging viral disease with fatal outcomes. However, no MERS-CoV-specific treatment is commercially available. Given the absence of previous structure-based drug discovery …
View article: Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice
Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice Open
Water-soluble dietary fiber such as inulin improves the beta diversity of the intestinal microbiota of mice fed with a high-fat diet (HFD). The circadian clock is the system that regulates the internal daily rhythm, and it affects the patt…
View article: Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule
Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule Open
Water-soluble dietary fiber is known to modulate fecal microbiota. Although there are a few reports investigating the effects of fiber intake timing on metabolism, there are none on the effect of intake timing on microbiota. Therefore, in …
View article: Ex-Vivo Expanded NK Cell Therapy Combined with Elotuzumab for MRD after Autologous Stem Cell Transplantation: A Phase I/ II Clinical Trial in Progress
Ex-Vivo Expanded NK Cell Therapy Combined with Elotuzumab for MRD after Autologous Stem Cell Transplantation: A Phase I/ II Clinical Trial in Progress Open
Recent advances of monoclonal antibodies provide a potent anti-myeloma effect based on antibody-dependent cytotoxicity (ADCC). Elotuzumab is a monoclonal antibody which binds SLAMF7 on the surface of myeloma cells and induces ADCC by NK ce…
View article: Phase I study of cellular therapy using <i>ex vivo</i> expanded natural killer cells from autologous peripheral blood mononuclear cells combined with rituximab-containing chemotherapy for relapsed CD20-positive malignant lymphoma patients
Phase I study of cellular therapy using <i>ex vivo</i> expanded natural killer cells from autologous peripheral blood mononuclear cells combined with rituximab-containing chemotherapy for relapsed CD20-positive malignant lymphoma patients Open
Phase I study of cellular therapy using ex vivo expanded natural killer cells from autologous peripheral blood mononuclear cells combined with rituximab-containing chemotherapy for relapsed CD20-positive malignant lymphoma patients7][8] In…