Ayda Rostamzadeh
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View article: An unsupervised XAI framework for dementia detection with context enrichment
An unsupervised XAI framework for dementia detection with context enrichment Open
Explainable Artificial Intelligence (XAI) methods enhance the diagnostic efficiency of clinical decision support systems by making the predictions of a convolutional neural network’s (CNN) on brain imaging more transparent and trustworthy.…
View article: Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia
Long-term retrieval performance is associated with CA1 hippocampal volume in older adults and individuals at risk for dementia Open
Background Long-term retrieval (LTR) and accelerated long-term forgetting (ALF) paradigms might help differentiating individuals at increased dementia risk from healthy controls (HC). Objective We investigated the utility of a LTR paradigm…
View article: Disclosure of Alzheimer’s disease blood-based biomarker results in a primary care setting: Opportunities and challenges
Disclosure of Alzheimer’s disease blood-based biomarker results in a primary care setting: Opportunities and challenges Open
Blood-based biomarkers (BBMs) for Alzheimer's disease (AD) have advanced rapidly and may be a critical tool for broad community-based screening for AD and detection of AD pathology in individuals with cognitive impairment. To meet the impe…
View article: Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease
Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease Open
Background Speech-based features extracted from telephone-based cognitive tasks show promise for detecting cognitive decline in prodromal and manifest dementia. Little is known about the cerebral underpinnings of these speech features. Obj…
View article: Dementia risk estimation in persons at risk and the predictive turn in Alzheimer’s disease—The PreTAD project: Study protocol with an ethical, clinical, linguistic, and legal approach
Dementia risk estimation in persons at risk and the predictive turn in Alzheimer’s disease—The PreTAD project: Study protocol with an ethical, clinical, linguistic, and legal approach Open
Background Despite progress in the field of Alzheimer’s disease (AD) dementia risk estimation, little is known about its impact at the individual and societal levels. Objective Introducing the explorative tri-national PreTAD project (The P…
View article: Disease stage–specific atrophy markers in Alzheimer's disease
Disease stage–specific atrophy markers in Alzheimer's disease Open
INTRODUCTION Structural magnetic resonance imaging (MRI) often lacks diagnostic, prognostic, and monitoring value in Alzheimer's disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal atrop…
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: Smartphone-based detection of memory decline in prodromal Alzheimer’s disease
Smartphone-based detection of memory decline in prodromal Alzheimer’s disease Open
The slow progression of Alzheimer’s disease (AD) poses a challenge for the rapid and individual quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive …
View article: Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease
Disrupted Forward Connectivity in Parieto-temporal Network Impairs Memory Performance in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is characterised by the accumulation of beta-amyloid (Aβ) and tau proteins, leading to neurodegeneration and cognitive decline. While Aβ and tau are known to disrupt synaptic function, the mechanisms linking these …
View article: An Unsupervised XAI Framework for Dementia Detection with Context Enrichment
An Unsupervised XAI Framework for Dementia Detection with Context Enrichment Open
Introduction Explainable Artificial Intelligence (XAI) methods enhance the diagnostic efficiency of clinical decision support systems by making the predictions of a convolutional neural network’s (CNN) on brain imaging more transparent and…
View article: Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores
Speech-based digital cognitive assessments for detection of mild cognitive impairment: Validation against paper-based neurocognitive assessment scores Open
Background Cognitive decline in Alzheimer's disease (AD) often includes speech impairments, where subtle changes may precede clinical dementia onset. As clinical trials focus on early identification of patients for disease-modifying treatm…
View article: A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans
A computational ontology framework for the synthesis of multi-level pathology reports from brain MRI scans Open
Background Convolutional neural network (CNN) based volumetry of MRI data can help differentiate Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD) as causes of cognitive decline and dementia. However, e…
View article: Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease
Blood biomarkers confirm subjective cognitive decline (SCD) as a distinct molecular and clinical stage within the NIA-AA framework of Alzheimer´s disease Open
Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limite…
View article: Fully automated MRI‐based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI‐Net
Fully automated MRI‐based analysis of the locus coeruleus in aging and Alzheimer's disease dementia using ELSI‐Net Open
INTRODUCTION The locus coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). Magnetic resonance imaging–based LC features have shown potential to assess LC integrity…
View article: Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function
Perivascular space and white matter hyperintensities in Alzheimer’s disease: associations with disease progression and cognitive function Open
View article: Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities
Brain health services for the secondary prevention of cognitive impairment and dementia: Opportunities, challenges, and the business case for existing and future facilities Open
View article: Disease stage-specific atrophy markers in Alzheimer’s disease
Disease stage-specific atrophy markers in Alzheimer’s disease Open
INTRODUCTION Structural MRI often lacks diagnostic, prognostic, and monitoring value in Alzheimer’s disease (AD), particularly in early disease stages. To improve its utility, we aimed to identify optimal MRI readouts for different use cas…
View article: Linking higher amyloid beta 1‐38 (Aβ(1‐38)) levels to reduced Alzheimer's disease progression risk
Linking higher amyloid beta 1‐38 (Aβ(1‐38)) levels to reduced Alzheimer's disease progression risk Open
INTRODUCTION The beneficial effects of amyloid beta 1‐38, or Aβ(1‐38), on Alzheimer's disease (AD) progression in humans in vivo remain controversial. We investigated AD patients' cerebrospinal fluid (CSF) Aβ(1‐38) and AD progression. METH…
View article: Dementia Risk Factor Assessment in a Local Alzheimer’s Prevention Population: A German Cross-Sectional, Observational Study
Dementia Risk Factor Assessment in a Local Alzheimer’s Prevention Population: A German Cross-Sectional, Observational Study Open
View article: Facing the new diagnostic and treatment options of Alzheimer's disease: The necessity of informed consent
Facing the new diagnostic and treatment options of Alzheimer's disease: The necessity of informed consent Open
With advances in biomarker‐based detection of Alzheimer's disease (AD) and new treatment options with disease‐modifying treatments (DMTs), we are heading toward a new conceptualization of diagnostics and therapy in the early stages of AD. …
View article: CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum
CSF biomarkers are differentially linked to brain areas high and low in noradrenaline, dopamine and serotonin across the Alzheimer’s disease spectrum Open
Neurotransmitter systems of noradrenaline, dopamine, serotonin and acetylcholine are implicated in cognitive functions such as memory, learning and attention and are known to be altered in neurodegenerative diseases like Alzheimer’s diseas…
View article: Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults
Environmental enrichment is associated with favorable memory-related functional brain activity patterns in older adults Open
Background In humans, environmental enrichment (EE), as measured by the engagement in a variety of leisure activities, has been associated with larger hippocampal structure and better memory function. The present cross-sectional study asse…
View article: Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease
Locus coeruleus signal intensity and emotion regulation in agitation in Alzheimer’s disease Open
Hyperphosphorylated tau accumulation is seen in the noradrenergic locus coeruleus from the earliest stages of Alzheimer’s disease onwards and has been associated with symptoms of agitation. It is hypothesized that compensatory locus coerul…
View article: Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects
Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects Open
Background Quantification of Amyloid beta (Aβ) oligomers in plasma enables early diagnosis of Alzheimer’s Disease (AD) and improves our understanding of underlying pathologies. However, quantification necessitates an extremely sensitive an…
View article: Preclinical Dementia Risk Estimation: Attitudes and Views of Relatives of Dementia Patients – The PreTAD‐Study
Preclinical Dementia Risk Estimation: Attitudes and Views of Relatives of Dementia Patients – The PreTAD‐Study Open
Background Due to further development of diagnostic methods of early‐stage diagnosis of Alzheimer’s disease (AD) and new disease‐modifying treatment options that require early diagnosis, a new focus on predictive and preventive medicine ar…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: Attitudes and Expectations regarding Dementia Risk Estimation among the General Population in Germany, Spain, and Switzerland
Attitudes and Expectations regarding Dementia Risk Estimation among the General Population in Germany, Spain, and Switzerland Open
Background In recent years, research on risk estimation and early detection of Alzheimer’s disease (AD) advanced swiftly. Studies are investigating the likelihood of developing Alzheimer’s dementia (ADD), even during asymptomatic, preclini…
View article: “I assume that my doctor will then guide me”: Attitudes and Expectations in the Context of Dementia Risk Estimation
“I assume that my doctor will then guide me”: Attitudes and Expectations in the Context of Dementia Risk Estimation Open
Background Driven by (bio‐)medical and technical developments, advanced non‐invasive methods for estimating the risk of Alzheimer’s dementia (ADD) are increasingly emerging. In the future, such methods could eventually become available for…
View article: A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting
A generalizable data‐driven model of atrophy heterogeneity and progression in a memory clinic setting Open
Background Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’…
View article: Omega‐6/Omega‐3 Ratio in Dementia Prevention ‐ Study Design and preliminary data of a feasibility study on lifestyle intervention
Omega‐6/Omega‐3 Ratio in Dementia Prevention ‐ Study Design and preliminary data of a feasibility study on lifestyle intervention Open
Background Alzheimer’s disease (AD) is the most common etiology of dementia. As the progression of the disease may be slowed down by disease‐modifying therapies, but not stopped, research identifying further therapeutic approaches is neces…