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View article: Supplemental Table 1 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 1 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 1
View article: Supplementary Figure 1 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 1 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Overview of the targeting strategy employed for creation of the Prkcd conditional knockout mice
View article: Supplementary Figure 9 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 9 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
SNP alleles correlate with an M1/M2 gene signature score
View article: Data from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Data from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned that novel targets for cancer immunotherapy might be identified through germline variants associated with greater T-cell infiltra…
View article: Supplementary Figure 5 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 5 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
GSEA reveals many macrophage-related gene sets that are enriched in the C1qa DEG list.
View article: Supplementary Figure 6 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 6 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in “2B4”Prkcdfl/fl founder.
View article: Supplemental Table 5 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 5 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 5
View article: Supplementary Figure 3 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 3 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
T cell priming is unaltered with hematopoietic loss of PKCδ
View article: Supplemental Table 3 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 3 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 3
View article: Supplemental Table 4 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 4 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 4
View article: Supplementary Figure 8 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 8 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Loss of PKCδ in myeloid cells delays tumor growth and is further delayed with anti-PD-L1 therapy in multiple Prkcdfl/fl founders.
View article: Supplementary Figure 7 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 7 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Hematopoietic loss of PKCδ via Vav1-iCre delays tumor growth and alters inflammatory gene expression in alternative “2C1”Prkcdfl/fl founder.
View article: Supplemental Table 6 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 6 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 6
View article: Supplementary Figure 4 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 4 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Hematopoietic loss of PKCδ leads to an altered immune response
View article: Supplemental Table 2 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 2 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 2
View article: Supplementary Figure 2 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplementary Figure 2 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
SNP alleles correlate with PRKCD expression and the 160 gene signature score
View article: Supplemental Table 7 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells
Supplemental Table 7 from PKCδ Germline Variants and Genetic Deletion in Mice Augment Antitumor Immunity through Regulation of Myeloid Cells Open
Supplemental Table 7
View article: Colorectal cancer detection and treatment with engineered probiotics
Colorectal cancer detection and treatment with engineered probiotics Open
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral…
View article: Hepatitis C Virus Prevalence, Medical Status Awareness and Treatment Engagement among Homeless People Who use Drugs: Results of a Street Outreach Study
Hepatitis C Virus Prevalence, Medical Status Awareness and Treatment Engagement among Homeless People Who use Drugs: Results of a Street Outreach Study Open
Background: Hepatitis C virus (HCV) infection is a primary health concern among people who use drugs (PWUDs). Homeless PWUDs that constitute a key population for HCV transmission remain underrepresented in many surveys. Objectives: We perf…
View article: 642 Decreased host PKC-delta is associated with the T cell-inflamed tumor microenvironment and improves anti-tumor immunity
642 Decreased host PKC-delta is associated with the T cell-inflamed tumor microenvironment and improves anti-tumor immunity Open
Background Favorable clinical responses to immunotherapy have been correlated with a T cell-inflamed tumor microenvironment. The degree of spontaneous immune infiltration in tumors varies widely between individual patients. We hypothesized…
View article: The composition of the microbiota modulates allograft rejection
The composition of the microbiota modulates allograft rejection Open
Transplantation is the only cure for end-stage organ failure, but without immunosuppression, T cells rapidly reject allografts. While genetic disparities between donor and recipient are major determinants of the kinetics of transplant reje…
View article: Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone
Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone Open
Breast cancer cells traffic to and from the peripheral blood within specific vascular niches, and this migration can be therapeutically targeted.