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View article: Once‐Weekly Insulin Efsitora Alfa Versus Once Daily Insulin in Patients With Type 2 Diabetes: A Systematic Review and Meta‐Analysis
Once‐Weekly Insulin Efsitora Alfa Versus Once Daily Insulin in Patients With Type 2 Diabetes: A Systematic Review and Meta‐Analysis Open
Background Once‐daily basal insulin is widely used in the management of type 2 diabetes, but poor adherence to daily injections often impairs glycaemic control. Once‐weekly efsitora alfa may overcome these limitations, but pooled data asse…
View article: Novel transferosome formulation of Vemurafenib for skin cancer management: biocompatible and scalable strategies
Novel transferosome formulation of Vemurafenib for skin cancer management: biocompatible and scalable strategies Open
Due to challenges such as poor aqueous solubility and compromised oral bioavailability, delivering Vemurafenib via a topical route using a scalable and biocompatible carrier-based hydrogel. This study aims to develop and characterize Vemur…
View article: Dissolving Microneedle Transdermal Patch Loaded with Nanoliposomes of <i>Enicostemma littorale</i> for the Management of Type II Diabetes
Dissolving Microneedle Transdermal Patch Loaded with Nanoliposomes of <i>Enicostemma littorale</i> for the Management of Type II Diabetes Open
Type 2 diabetes mellitus (T2DM) is the most common form of diabetes and presents a significant global health challenge, characterized by insulin resistance and a relative deficiency in insulin secretion. There is growing interest in explor…
View article: Optimization of Heat Transfer through Baffles and Various Velocity of Cold and Hot Fluid in Shell and Tube Heat Exchanger
Optimization of Heat Transfer through Baffles and Various Velocity of Cold and Hot Fluid in Shell and Tube Heat Exchanger Open
The present work investigates the influence of different baffle structure variations on the outlet temperature of "shell-and-tube heat exchangers" when used as waste heat recovery systems. The remaining thermal energy from liquid heated to…
View article: Proteomic Atlas of Post-COVID Sequelae
Proteomic Atlas of Post-COVID Sequelae Open
The emergence of post-COVID sequelae (PCS) represents a global challenge. However, understanding of biological mechanisms and the definition of quantifiable risk factors remains limited. This study harnessed the power of predictive machine…
View article: LC and LC-MS/MS Analysis for Characterization of Novel Degradation Products of Ivosidenib: Exploration of Degradation Pathways and In Silico Predictions
LC and LC-MS/MS Analysis for Characterization of Novel Degradation Products of Ivosidenib: Exploration of Degradation Pathways and In Silico Predictions Open
Ivosidenib (ISB) is an anticancer drug used to treat acute myeloid leukemia and cholangiocarcinoma. In order to determine and describe the degradation products (DPs) of ivosidenib, the International Conference on Harmonization (ICH) guidel…
View article: Decoding Prescriptions: A Closer Look At Common Errors In Clinical Practice Across Community Pharmacies Of Northern Cyprus
Decoding Prescriptions: A Closer Look At Common Errors In Clinical Practice Across Community Pharmacies Of Northern Cyprus Open
Prescription documentation is essential for patient safety and medication efficacy. However, incomplete or illegible prescriptions can lead to errors, including drug-drug interactions (DDIs). This study evaluated the completeness, clarity …
View article: Computational Development of New Inhibitors for Apoptosis Stimulating Protein of p53 (iASPP) Using Pharmacophore Modeling, Docking, and MD Simulation Approaches
Computational Development of New Inhibitors for Apoptosis Stimulating Protein of p53 (iASPP) Using Pharmacophore Modeling, Docking, and MD Simulation Approaches Open
Inhibitor of apoptosis-stimulating protein of p53 (iASPP) overexpression is associated with diverse human tumors, including lung cancer, colorectal cancer, prostate cancer, acute leukemia, hepatocellular carcinoma, cervical cancer, and ova…
View article: Rutin-Loaded Transethosomal Gel for Topical Application: A Comprehensive Analysis of Skin Permeation and Antimicrobial Efficacy
Rutin-Loaded Transethosomal Gel for Topical Application: A Comprehensive Analysis of Skin Permeation and Antimicrobial Efficacy Open
This study conducts a systematic investigation of the creation and optimization of a rutin-loaded transethosome intended for topical use. The formulation's characteristics were thoroughly assessed for vesicle size (160.45 ± 1.98 nm), polyd…
View article: Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies
Optimized Ribociclib nanostructured lipid carrier for the amelioration of skin cancer: Inferences from ex-vivo skin permeation and dermatokinetic studies Open
Current research focuses on explicitly developing and evaluating nanostructured lipidic carriers (NLCs) for the chemotherapeutic drug Ribociclib (RCB) via the topical route to surmount the inherent bioavailability shortcomings. The absolut…
View article: Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the Liver Tissue of STZ-Induced Diabetes in Mice
Effects of kaempherol-3-rhamnoside on metabolic enzymes and AMPK in the Liver Tissue of STZ-Induced Diabetes in Mice Open
The current study aimed to investigate the potential antidiabetic properties of kaempherol-3-rhamnoside (Afzelin), both alone and in combination with insulin. To accomplish this, different groups of animals received kaempherol-3-rhamnoside…
View article: Nanogel-Based Delivery System for Lemongrass Essential Oil: A Promising Approach to Overcome Antibiotic Resistance in Pseudomonas aeruginosa Infections
Nanogel-Based Delivery System for Lemongrass Essential Oil: A Promising Approach to Overcome Antibiotic Resistance in Pseudomonas aeruginosa Infections Open
The emergence of antibiotic-resistant strains of Pseudomonas aeruginosa (P. aeruginosa) presents a substantial obstacle in medical environments. To effectively tackle this problem, we suggest an innovative approach: employing a delivery sy…
View article: Antipsoriatic evaluation of a novel gel containing Chrysin nanostructured lipid carriers and probiotic in imiquimod induced mice model
Antipsoriatic evaluation of a novel gel containing Chrysin nanostructured lipid carriers and probiotic in imiquimod induced mice model Open
Psoriasis is a multifactorial skin disorder. Hence, its treatment using combination of Chrysin (CS) and probiotic (PB) could be effective strategy. In the present study, CS nano structured lipid carriers (NLCs) were prepared by modified ho…
View article: Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer
Synergistic Combination of Letrozole and Berberine in Ascorbic Acid-Stabilized AuNPs: A Promising Solution for Breast Cancer Open
Breast cancer is a deadly disease that affects countless women worldwide. The most conventional treatments for breast cancer, such as the administration of anticancer medications such as letrozole (LTZ), pose significant barriers due to th…
View article: Gallic-Acid-Loaded PLGA Nanoparticles: A Promising Transdermal Drug Delivery System with Antioxidant and Antimicrobial Agents
Gallic-Acid-Loaded PLGA Nanoparticles: A Promising Transdermal Drug Delivery System with Antioxidant and Antimicrobial Agents Open
The objective of this study was to develop an innovative gallic-acid (GA) drug delivery system that could be administered transdermally, resulting in enhanced therapeutic benefits and minimal negative consequences. The method employed invo…
View article: Beta Caryophyllene-Loaded Nanostructured Lipid Carriers for Topical Management of Skin Disorders: Statistical Optimization, In Vitro and Dermatokinetic Evaluation
Beta Caryophyllene-Loaded Nanostructured Lipid Carriers for Topical Management of Skin Disorders: Statistical Optimization, In Vitro and Dermatokinetic Evaluation Open
This work aimed to overcome the disadvantages of the oral administration of beta-caryophyllene and boost efficiency by developing a nanostructured lipid carrier for topical administration of the drug in skin disorders. The heat emulsificat…
View article: Exploring the Therapeutic Potential of Berberine and Tocopherol in Managing Diabetic Neuropathy: A Comprehensive Approach towards Alleviating Chronic Neuropathic Pain
Exploring the Therapeutic Potential of Berberine and Tocopherol in Managing Diabetic Neuropathy: A Comprehensive Approach towards Alleviating Chronic Neuropathic Pain Open
Diabetic neuropathy (DN) causes sensory dysfunction, such as numbness, tingling, or burning sensations. Traditional medication may not ease pain and discomfort, but natural remedies such as Berberine (BR) and vitamin E or Tocopherol (TOC) …
View article: QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders
QbD-Optimized, Phospholipid-Based Elastic Nanovesicles for the Effective Delivery of 6-Gingerol: A Promising Topical Option for Pain-Related Disorders Open
In this study, elastic nanovesicles, constructed of phospholipids optimized by Quality by Design (QbD), release 6-gingerol (6-G), a natural chemical that may alleviate osteoporosis and musculoskeletal-related pain. A 6-gingerol-loaded tran…
View article: Linagliptin in Combination with Emblica officinalis Gaertn Improves Glycemic Control through Alleviating Dyslipidemia and Oxidative Stress on Streptozotocin Induced Diabetic Rats
Linagliptin in Combination with Emblica officinalis Gaertn Improves Glycemic Control through Alleviating Dyslipidemia and Oxidative Stress on Streptozotocin Induced Diabetic Rats Open
Objectives: Diabetes is a complex chronic metabolic disorder. Today, many diabetes patients are known to supplement their standard therapies with herbal medications that have antidiabetic characteristics. The purpose of the study was to ex…
View article: Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model
Effects of Taraxerol on Oxidative and Inflammatory Mediators in Isoproterenol-Induced Cardiotoxicity in an Animal Model Open
Myocardial infarction (MI) continues to be an important issue in healthcare systems worldwide, leading to high rates of morbidity and mortality. Despite ongoing efforts towards the development of preventive measures and treatments, address…
View article: Quality-by-Design-Assisted Optimization of Carvacrol Oil-Loaded Niosomal Gel for Anti-Inflammatory Efficacy by Topical Route
Quality-by-Design-Assisted Optimization of Carvacrol Oil-Loaded Niosomal Gel for Anti-Inflammatory Efficacy by Topical Route Open
Niosomes are multilamellar vesicles that effectively transfer active ingredients into the skin’s layers. To improve the active substance’s penetration across the skin, these carriers are frequently utilized as topical drug delivery systems…