Ali Irfan
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View article: Ultrasonic-assisted, additive-free Pd-catalyzed Suzuki–Miyaura cross-coupling enabled synthesis of novel arylated benzofuran-triazole hybrids
Ultrasonic-assisted, additive-free Pd-catalyzed Suzuki–Miyaura cross-coupling enabled synthesis of novel arylated benzofuran-triazole hybrids Open
An additive-free and ultrasound-assisted approach has been established for the Suzuki–Miyaura cross-coupling reaction between substituted boronic acid and benzofuran-endowed aryl halides by employing a catalytic amount of Pd(PPh 3 ) 4 . Th…
View article: Integrated experimental and computational study of novel pyrrole derivatives: Microwave-assisted synthesis, enzyme inhibition, antioxidant properties, and neurotoxicity evaluation
Integrated experimental and computational study of novel pyrrole derivatives: Microwave-assisted synthesis, enzyme inhibition, antioxidant properties, and neurotoxicity evaluation Open
View article: Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening
Design, Synthesis, and Evaluation of Pyrrole-Based Selective MAO-B Inhibitors with Additional AChE Inhibitory and Neuroprotective Properties Identified via Virtual Screening Open
Background: Virtual screening is a widely adopted technique for the discovery of novel pharmacologically active compounds; however, the risk of identifying false positive hits remains a major challenge. Aim: The aim of this study was to pe…
View article: Fabrication and Characterization of Environmentally Friendly Bioplastic Film Based on Chitosan from Cassava Peel Starch
Fabrication and Characterization of Environmentally Friendly Bioplastic Film Based on Chitosan from Cassava Peel Starch Open
Bioplastics are renewable materials capable of natural degradation and can be synthesized using bio-organic compounds such as cellulose, chitosan, carboxymethyl cellulose (CMC), and glycerol. Cassava peels, an agricultural byproduct, are a…
View article: Phytochemical profiling, antioxidant potential, and in silico evaluation of Carica papaya seed oil
Phytochemical profiling, antioxidant potential, and in silico evaluation of Carica papaya seed oil Open
View article: Multi-target monoamine oxidase-B (MAO-B) inhibitors in the treatment of Parkinson’s disease
Multi-target monoamine oxidase-B (MAO-B) inhibitors in the treatment of Parkinson’s disease Open
Parkinson’s disease (PD) is a fast-advancing disorder of the nervous system, ranking only behind Alzheimer’s disease as the most prevalent neurodegenerative condition associated with aging. Its incidence increases with age – being relative…
View article: Novel thiazole derivatives as effective anti-cancer agents against human osteosarcoma cell line (SaOS-2): Microwave-assisted one-pot three-component synthesis, in vitro anti-cancer studies, and in silico investigations
Novel thiazole derivatives as effective anti-cancer agents against human osteosarcoma cell line (SaOS-2): Microwave-assisted one-pot three-component synthesis, in vitro anti-cancer studies, and in silico investigations Open
The current research involves the preparation of novel thiazole derivatives, which was carried out via one-pot three-component reaction utilizing conventional and microwave irradiation (MW) methods. The MW method reduced the reaction time …
View article: Enhanced production of extracellular L-asparaginase in batch culture via nitrous acid-induced mutagenesis of Aspergillus oryzae
Enhanced production of extracellular L-asparaginase in batch culture via nitrous acid-induced mutagenesis of Aspergillus oryzae Open
View article: Anxiolytic effect of zinc oxide gallic acid composite nanoparticles following D-galactose administration in rats
Anxiolytic effect of zinc oxide gallic acid composite nanoparticles following D-galactose administration in rats Open
View article: Synthesis, biological evaluation, and molecular docking of benzhydrazide derivatives
Synthesis, biological evaluation, and molecular docking of benzhydrazide derivatives Open
In the pursuit of discovering and developing compounds with antioxidant and other biological activities, we designed, synthesized, and evaluated 10 hydrazide-hydrazone derivatives of 4-hydroxybenzohydrazide (ohbh1-10) as potential antioxid…
View article: Synergistic photocatalytic and biomedical applications of Ag₂O-immobilized Bacillus subtilis-hyaluronic acid
Synergistic photocatalytic and biomedical applications of Ag₂O-immobilized Bacillus subtilis-hyaluronic acid Open
This study reports the synthesis of hyaluronic acid-coated silver oxide (Ag2O) nano-adsorbents using Bacillus subtilis PV154141.1 for dual environmental and biomedical applications. Multiple parameters were optimized for the for…
View article: Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs
Assessing the pulmonary oxidative stress and histopathological changes in Swiss albino mice following exposure to MWCNT-NPs Open
View article: Exploring the toxicological and beneficial effects of 4,5,6-Trimethoxy-2,3-diphenyl indole on Labeo rohita fingerlings
Exploring the toxicological and beneficial effects of 4,5,6-Trimethoxy-2,3-diphenyl indole on Labeo rohita fingerlings Open
View article: Evaluating the efficacy of Chenopodium murale plant extract in inhibiting Streptococcus mutans and reducing dental caries risk
Evaluating the efficacy of Chenopodium murale plant extract in inhibiting Streptococcus mutans and reducing dental caries risk Open
The relationship between Streptococcus mutans and dental caries has been a key focus of research due to the widespread prevalence of caries in humans. In this study, we have investigated the antimicrobial activity of Chenopodium murale (C.…
View article: Synthesis, characterization, DFT calculations, comparative in vitro and in silico screening of anti-bacterial, anti-urease and α-amylase inhibition activities of indole derivatives with hirshfeld surface analysis and crystal structure explorations of Bis(4,6-dimethoxy-2,3-diphenyl-1H-7,7΄-indolylmethane
Synthesis, characterization, DFT calculations, comparative in vitro and in silico screening of anti-bacterial, anti-urease and α-amylase inhibition activities of indole derivatives with hirshfeld surface analysis and crystal structure explorations of Bis(4,6-dimethoxy-2,3-diphenyl-1H-7,7΄-indolylmethane Open
View article: Standardization of pharmacognostic characters and phytochemical study of Limeum obovatum vicary
Standardization of pharmacognostic characters and phytochemical study of Limeum obovatum vicary Open
View article: Computational screening of natural products as tryptophan 2,3-dioxygenase inhibitors: Insights from CNN-based QSAR, molecular docking, ADMET, and molecular dynamics simulations
Computational screening of natural products as tryptophan 2,3-dioxygenase inhibitors: Insights from CNN-based QSAR, molecular docking, ADMET, and molecular dynamics simulations Open
Parkinson's disease (PD) is characterised by a complex array of motor, psychiatric, and gastrointestinal symptoms, many of which are linked to disruptions in neuroactive metabolites. Dysregulated activity of tryptophan 2,3-dioxygenase (TDO…
View article: Acipimox mitigates depression like behavior following high fat rich diet in rats
Acipimox mitigates depression like behavior following high fat rich diet in rats Open
Acipimox (ACPX), a niacin derivative, has demonstrated antioxidant activity In vitro and In vivo; however, it has not been widely used in treating neurological problems. The present study examined the effects of Acipimox on body weight, di…
View article: Effect of daily thinning on biweekly increment of growth and yield of maize (Zea mays L.) in mountainous agroecosystem
Effect of daily thinning on biweekly increment of growth and yield of maize (Zea mays L.) in mountainous agroecosystem Open
View article: Author Correction: Green-synthesized silver nanoparticle-enhanced nanofiltration mixed matrix membranes for high-performance water purification
Author Correction: Green-synthesized silver nanoparticle-enhanced nanofiltration mixed matrix membranes for high-performance water purification Open
View article: Synthesis, spectral characterization, antioxidant and antidiabetic activities of transition metal complexes of 4-aminoantipyrine: experimental and theoretical studies
Synthesis, spectral characterization, antioxidant and antidiabetic activities of transition metal complexes of 4-aminoantipyrine: experimental and theoretical studies Open
View article: Polyol Formation of Silver@Metal Oxides Nanohybrid for Photocatalytic and Antibacterial Performance
Polyol Formation of Silver@Metal Oxides Nanohybrid for Photocatalytic and Antibacterial Performance Open
The polyol method under a single pot has successfully produced a coating of CuO, TiO2, and the combination of CuO/TiO2 around Ag NWs under sequential addition. The Ag NWs and their coating with a pure metal oxide and a hybrid of metal oxid…
View article: Exploring antidiabetic potential of Nigella sativa and Silybum marianum seed extracts through bioassay-guided alpha-amylase inhibition activity and characterization of bioactive fractions
Exploring antidiabetic potential of Nigella sativa and Silybum marianum seed extracts through bioassay-guided alpha-amylase inhibition activity and characterization of bioactive fractions Open
Diabetes mellitus is a global health threat, and natural remedies are gaining attention due to the severe side effects of synthetic drugs. The current study explores the antidiabetic potential of individual seed extracts and their combinat…
View article: Chondroitin sulfate: An ideal biomaterial based scaffolds for cartilage regeneration and its therapeutic potential
Chondroitin sulfate: An ideal biomaterial based scaffolds for cartilage regeneration and its therapeutic potential Open
Chondroitin sulfate is an anionic glycosaminoglycan derived from animal and marine sources, as well as synthesized in the human body and by microbes. It is characterized by its recurring sequential disaccharide units of D-glucuronic acid a…
View article: Gallic acid alleviates omeprazole-induced depressive behavior and memory impairment
Gallic acid alleviates omeprazole-induced depressive behavior and memory impairment Open
View article: Applications of Ionic Liquids in Pharmaceuticals
Applications of Ionic Liquids in Pharmaceuticals Open
Ionic liquids (ILs) have emerged as a cutting-edge frontier in the realm of science and technology, offering a unique blend of tunable physicochemical and biological features with eco-friendly characteristics. Thus, ILs exhibit a broad spe…
View article: Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents
Synthesis and biological evaluation of rationally designed pyrazoles as insecticidal agents Open
The current research focused on the synthesis of two series of pyrazole derivatives and evaluation of their insecticidal effectiveness. In the first series, seven pyrazole Schiff bases 3a-g were successfully synthesized with yields (79-95%…
View article: Green-synthesized silver nanoparticle-enhanced nanofiltration mixed matrix membranes for high-performance water purification
Green-synthesized silver nanoparticle-enhanced nanofiltration mixed matrix membranes for high-performance water purification Open
View article: Integrating biotechnology into diagnostic labs: Innovations in PCR and molecular procedures
Integrating biotechnology into diagnostic labs: Innovations in PCR and molecular procedures Open
The field of biotechnology has significantly contributed to progress in diagnostic laboratories, especially in the early identification of genetic disorders. Timely detection plays a vital role in the treatment and management of such condi…
View article: Exploring the Antidiabetic Potential of Pyrimidine‐Derived Chalcones: Synthesis, Biological Evaluation, and Molecular Modeling
Exploring the Antidiabetic Potential of Pyrimidine‐Derived Chalcones: Synthesis, Biological Evaluation, and Molecular Modeling Open
In the current research work, we have prepared a series of pyrimidine moiety‐containing molecules due to their promising medicinal profile. First of all, we prepared two acetyl derivatives of pyrimidine ( 15 , 16 ), and then they reacted w…