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View article: Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells
Liver X Receptors Enhance Epithelial to Mesenchymal Transition in Metastatic Prostate Cancer Cells Open
Prostate cancer (PCa) is one of the most common cancers in men. Metastasis is the leading cause of death in prostate cancer patients. One of the crucial processes involved in metastatic spread is the “epithelial–mesenchymal transition” (EM…
View article: Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis
Cholesterol Dietary Intake and Tumor Cell Homeostasis Drive Early Epithelial Tumorigenesis: A Potential Modelization of Early Prostate Tumorigenesis Open
Epidemiological studies point to cholesterol as a possible key factor for both prostate cancer incidence and progression. It could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies des…
View article: Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis
Cholesterol Dietary Intake and Tumour Cell Metabolism Drive Early Epithelial Tumorigenesis Open
Epidemiological studies point cholesterol as a possible key factor for both prostate cancer incidence and progression. So, it could represent a targetable metabolite as the most aggressive tumors also appear to be sensitive to therapies de…
View article: Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress
Cannabidiol protects C2C12 myotubes against cisplatin-induced atrophy by regulating oxidative stress Open
In an in vitro model, cisplatin treatment led to myotube atrophy associated with dysregulation of protein homeostasis and increased oxidative stress, resulting in increased apoptosis. Cotreatment with cannabidiol was able to prevent this p…
View article: Le cannabidiol prévient le stress oxydant et corrige certaines atteintes mitochondriales musculaires induite par le cisplatine dans un modèle de myotubes en culture
Le cannabidiol prévient le stress oxydant et corrige certaines atteintes mitochondriales musculaires induite par le cisplatine dans un modèle de myotubes en culture Open
View article: Three-dimensional imaging of vascular development in the mouse epididymis
Three-dimensional imaging of vascular development in the mouse epididymis Open
Long considered an accessory tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fertility. In addition to its secretory role in ensuring functional maturation and survival of spermatozoa, the …
View article: Ricin B lectin-like proteins of the microsporidian Encephalitozoon cuniculi and Anncaliia algerae are involved in host-cell invasion
Ricin B lectin-like proteins of the microsporidian Encephalitozoon cuniculi and Anncaliia algerae are involved in host-cell invasion Open
View article: Mechanisms of epithelial mesenchymal transition by TGF-ß and LXRs in metastatic prostate cancer
Mechanisms of epithelial mesenchymal transition by TGF-ß and LXRs in metastatic prostate cancer Open
View article: LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames
LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames Open
Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has be…
View article: Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia
Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasia Open
Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points the role of metabolic disorders as a potential source of ca…
View article: Screening for liver X receptor modulators: Where are we and for what use?
Screening for liver X receptor modulators: Where are we and for what use? Open
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are canonically activated by oxidized derivatives of cholesterol. Since the mid‐90s, numerous groups have identified LXRs as endocrine receptors that are involve…
View article: Inducing Plant Defense Reactions in Tobacco Plants with Phenolic-Rich Extracts from Red Maple Leaves: A Characterization of Main Active Ingredients
Inducing Plant Defense Reactions in Tobacco Plants with Phenolic-Rich Extracts from Red Maple Leaves: A Characterization of Main Active Ingredients Open
Red maple leaf extracts (RME) were tested for their plant defense inducer (PDI) properties. Two extracts were obtained and compared by different approaches: RME1 using ethanol–water (30–70%, v/v, 0.5% HCl 1N) and RME2 using pure water. Bot…
View article: Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis1
Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis1 Open
After its production in the testis, a spermatozoon has to undergo posttesticular maturation steps to become fully motile and fertile. The first step is epididymal maturation, during which immature spermatozoa are transformed into biochemic…