Ayodeji A. Asuni
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View article: SUN-012 HPA Axis Dynamics During Chronic Corticosterone Exposure
SUN-012 HPA Axis Dynamics During Chronic Corticosterone Exposure Open
Disclosure: C. Ratner: Cecilia Ratner is emplyoed at Lundbeck A/S. V. Nielsen: Vibeke Nielsen is employed at Lundbeck A/S. M. Lubas: Michal Lubas is employed at Lundbeck A/S. M. Grupe Frost: Morten Grupe Frost is employed at Lundbeck A/S. …
View article: Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice
Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice Open
MAGL inhibitor effectively blocked acute and chronic migraine-associated pain, likely through prolonged endocannabinoid action. This effect may be mediated through action at peripheral or central sites considering the high MAGL and CB…
View article: Highly Sensitive Assays for detection of headache inducing neuropeptides, Pituitary adenylate cyclase-activating polypeptide (PACAP) and Calcitonin gene-related peptide (CGRP)
Highly Sensitive Assays for detection of headache inducing neuropeptides, Pituitary adenylate cyclase-activating polypeptide (PACAP) and Calcitonin gene-related peptide (CGRP) Open
Background Migraine is one of the most disabling diseases that continues to pose a significant societal burden. Although there are now treatment options for people with migraine, it remains challenging to identify them as clinical features…
View article: Sex differences in the murine HPA axis after acute and repeated restraint stress
Sex differences in the murine HPA axis after acute and repeated restraint stress Open
Chronic stress and stress-related mental illnesses such as major depressive disorder (MDD) constitute some of the leading causes of disability worldwide with a higher prevalence in women compared to men. However, preclinical research into …
View article: Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody
Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody Open
View article: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model
VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model Open
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a rece…
View article: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model
VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model Open
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a rece…
View article: Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody
Application of 89Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody Open
Purpose The recent conditional FDA approval of Aducanumab (Adu) for treating Alzheimer’s disease (AD) and the continued discussions around that decision have increased interest in immunotherapy for AD and other brain diseases. Reliable tec…
View article: Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus)
Amyloid-β targeting immunisation in aged non-human primate (Microcebus murinus) Open
View article: Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – The choice of chelator is essential
Advancing 89Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody – The choice of chelator is essential Open
The accelerated approval of the monoclonal antibody (mAb) aducanumab as a treatment option for Alzheimer’s Disease and the continued discussions about its efficacy have shown that a better understanding of immunotherapy for the treatment o…
View article: Amyloid-β targeting immunisation in aged non-human primate (<i>Microcebus murinus</i>)
Amyloid-β targeting immunisation in aged non-human primate (<i>Microcebus murinus</i>) Open
Non-human primates have an important translational value given their close phylogenetic relationship to humans. Studies in these animals remain essential for evaluating efficacy and safety of new therapeutic approaches, particularly in agi…
View article: Advancing <sup>89</sup>Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody - The choice of chelator is essential
Advancing <sup>89</sup>Zr-immuno-PET in neuroscience with a bispecific anti-amyloid-beta monoclonal antibody - The choice of chelator is essential Open
The accelerated approval of the monoclonal antibody (mAb) aducanumab as a treatment option for Alzheimer's Disease and the continued discussions about its efficacy have shown that a better understanding of immunotherapy for the treatment o…
View article: Chronic stress induces <scp>NPD</scp>‐like behavior in <scp>APPPS1</scp> and <scp>WT</scp> mice with subtle differences in gene expression
Chronic stress induces <span>NPD</span>‐like behavior in <span>APPPS1</span> and <span>WT</span> mice with subtle differences in gene expression Open
Neuropsychiatric disturbances (NPDs) are considered hallmarks of Alzheimer's disease (AD). Nevertheless, treatment of these symptoms has proven difficult and development of safe and effective treatment options is hampered by the limited un…
View article: Corrigendum to “SSP-27: 89Zr-immuno-PET of a novel bispecific amyloid β monoclonal antibody reveals improved and high specific brain uptake” [Nucl Med Biol (2020) Volumes 96–97, Supplement. S30-S31]
Corrigendum to “SSP-27: 89Zr-immuno-PET of a novel bispecific amyloid β monoclonal antibody reveals improved and high specific brain uptake” [Nucl Med Biol (2020) Volumes 96–97, Supplement. S30-S31] Open
View article: A preclinical model for modulation and characterisation of neuropsychiatric disturbances in Alzheimer’s disease
A preclinical model for modulation and characterisation of neuropsychiatric disturbances in Alzheimer’s disease Open
Background The events that direct the shift from asymptomatic to symptomatic Alzheimer’s disease (AD) have yet to be fully characterized, however the consensus is that neuropsychiatric disturbances (NPDs) play a significant role in this. M…
View article: Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer’s Disease: Insights From Preclinical Models, Clinical Data, and Future Directions
Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer’s Disease: Insights From Preclinical Models, Clinical Data, and Future Directions Open
Alzheimer's disease (AD) is the most common form of dementia worldwide. It is mostly known for its devastating effect on memory and learning but behavioral alterations commonly known as neuropsychiatric disturbances (NPDs) are also charact…
View article: Dual strategy for reduced signal‐suppression effects in matrix‐assisted laser desorption/ionization mass spectrometry imaging
Dual strategy for reduced signal‐suppression effects in matrix‐assisted laser desorption/ionization mass spectrometry imaging Open
Rationale The molecular complexity of tissue features several signal‐suppression effects which reduce the ionization of analytes significantly and thereby weakens the quality of matrix‐assisted laser desorption/ionization (MALDI) mass spec…
View article: Pathogenic tau does not drive activation of the unfolded protein response
Pathogenic tau does not drive activation of the unfolded protein response Open
The unfolded protein response (UPR) is commonly associated with a range of neurodegenerative diseases, and targeting UPR components has been suggested as a therapeutic strategy. The UPR surveys protein folding within the endoplasmic reticu…
View article: IC‐P‐175: INVESTIGATION OF THE AMYLOID PLAQUE PEPTIDOME IN A MOUSE MODEL OF ALZHEIMER'S DISEASE USING MALDI IMAGING
IC‐P‐175: INVESTIGATION OF THE AMYLOID PLAQUE PEPTIDOME IN A MOUSE MODEL OF ALZHEIMER'S DISEASE USING MALDI IMAGING Open
In order to develop improved treatments for Alzheimer's disease (AD), it is of great importance to gain deeper insight and understanding of the biological systems that are being targeted and the mechanisms by which they contribute to AD. W…
View article: Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease
Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease Open
There are nearly 50 million people with Alzheimer's disease (AD) worldwide and currently no disease modifying treatment is available. AD is characterized by deposits of Amyloid-β (Aβ), neurofibrillary tangles, and neuroinflammation, and se…
View article: Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tau
Highly specific and selective anti‐pS396‐tau antibody C10.2 targets seeding‐competent tau Open
Introduction The abnormal hyperphosphorylation of the microtubule‐associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD) and other tauopathies. Methods Highly specific and selective anti‐pS396‐tau anti…
View article: [P2–060]: CHARACTERIZATION OF A SMALL‐MOLECULE APP TRANSLATION INHIBITOR FOR ALZHEIMER's DISEASE PREVENTION AND THERAPY
[P2–060]: CHARACTERIZATION OF A SMALL‐MOLECULE APP TRANSLATION INHIBITOR FOR ALZHEIMER's DISEASE PREVENTION AND THERAPY Open
Progressive accumulation of β-amyloid (Aβ) in the brain is a critical upstream event in Alzheimer's disease (AD) pathogenesis and considered as a prime target for disease-modifying therapy of AD. Aβ is generated during proteolytic cleavage…
View article: Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo
Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo Open