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View article: Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route
Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route Open
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure c…
View article: Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route
Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route Open
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure c…
View article: Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primates
Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primates Open
After the 2022-2023 Sudan virus (SUDV) disease outbreak in Uganda, we studied SUDV persistence in nonhuman primates that had survived acute infection without therapeutic intervention. We identified SUDV persistence in the vitreous chamber …
View article: Small molecule protein assembly modulators with pan-cancer therapeutic efficacy
Small molecule protein assembly modulators with pan-cancer therapeutic efficacy Open
Two structurally unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against Mpox virus (formerly known as monkeypox virus) and human immunodeficiency virus (HIV) respe…
View article: Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors
Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors Open
View article: Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy
Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy Open
Two structurally-unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951 with antiviral activity in cell culture against monkeypox virus (MPXV) and human immunodeficiency virus (HIV) respectively, were studied for…
View article: What We Know About Monkeypox and What We Need to Do to Protect Ourselves!
What We Know About Monkeypox and What We Need to Do to Protect Ourselves! Open
The monkeypox (MPX) outbreak that started in the middle of May 2022 has spread to more than 30 countries, with around 8000 laboratory-confirmed cases as of July 8, 2022. It is expected to continue to spread throughout the world. Human MPX …
View article: Exposure Route Influences Disease Severity in the COVID-19 Cynomolgus Macaque Model
Exposure Route Influences Disease Severity in the COVID-19 Cynomolgus Macaque Model Open
The emergence of SARS-CoV-2 and the subsequent pandemic has highlighted the need for animal models that faithfully replicate the salient features of COVID-19 disease in humans. These models are necessary for the rapid selection, testing, a…
View article: A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model
A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine Is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model Open
The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies…
View article: A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model
A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model Open
The COVID-19 pandemic has had a staggering impact on social, economic, and public health systems worldwide. Vaccine development and mobilization against SARS-CoV-2 (the etiologic agent of COVID-19) has been rapid. However, novel strategies…
View article: Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease
Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease Open
Filoviruses (Family Filoviridae genera Ebolavirus and Marburgvirus ) are negative-stranded RNA viruses that cause severe health effects in humans and non-human primates, including death. Except in outbreak settings, vaccines and other medi…
View article: The Natural History of Aerosolized Francisella tularensis Infection in Cynomolgus Macaques
The Natural History of Aerosolized Francisella tularensis Infection in Cynomolgus Macaques Open
Tularemia is a severe, zoonotic infection caused by the Gram-negative bacterium Francisella tularensis. Inhalation results in a rapid, severe bacterial pneumonia and sepsis, which can be lethal. Because the cynomolgus macaque is the accept…
View article: Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure
Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure Open
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A compar…
View article: Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection Open
Emerging coronaviruses are a global public health threat because of the potential for person-to-person transmission and high mortality rates. Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012, causing lethal respirato…
View article: Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey
Modeling mosquito-borne and sexual transmission of Zika virus in an enzootic host, the African green monkey Open
Mosquito-borne and sexual transmission of Zika virus (ZIKV), a TORCH pathogen, recently initiated a series of large epidemics throughout the Tropics. Animal models are necessary to determine transmission risk and study pathogenesis, as wel…
View article: Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions
Persistence of Severe Acute Respiratory Syndrome Coronavirus 2 in Aerosol Suspensions Open
We aerosolized severe acute respiratory syndrome coronavirus 2 and determined that its dynamic aerosol efficiency surpassed those of severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome. Although we performed …
View article: Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions
Comparative dynamic aerosol efficiencies of three emergent coronaviruses and the unusual persistence of SARS-CoV-2 in aerosol suspensions Open
The emergent coronavirus, designated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a zoonotic pathogen that has demonstrated remarkable transmissibility in the human population and is the etiological agent of a current g…
View article: Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection Open
Emerging highly pathogenic coronaviruses (CoV) are a global public health threat due to the potential for person-to-person transmission and higher mortality rates than common seasonal respiratory pathogens. Middle East respiratory syndrome…
View article: Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection
Small Particle Aerosol Exposure of African Green Monkeys to MERS-CoV as a Model for Highly Pathogenic Coronavirus Infection Open
Emerging highly pathogenic coronaviruses (CoV) are a global public health threat due to the potential for person-to-person transmission and higher mortality rates than common seasonal respiratory pathogens. Middle East respiratory syndrome…
View article: African green monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
African green monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection Open
View article: Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings
Coccidioidomycosis in Nonhuman Primates: Pathologic and Clinical Findings Open
Coccidioidomycosis in nonhuman primates has been sporadically reported in the literature. This study describes 22 cases of coccidioidomycosis in nonhuman primates within an endemic region, and 79 cases of coccidioidomycosis from the veteri…
View article: High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus
High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus Open
Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus mac…
View article: Animal Models of Human Viral Diseases
Animal Models of Human Viral Diseases Open
View article: Comparison of experimental respiratory tularemia in three nonhuman primate species
Comparison of experimental respiratory tularemia in three nonhuman primate species Open
View article: Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New Zealand White Rabbit Partial Survival Model for Inhalational Anthrax
Efficacy of ETI-204 Monoclonal Antibody as an Adjunct Therapy in a New Zealand White Rabbit Partial Survival Model for Inhalational Anthrax Open
Inhalational anthrax is characterized by extensive bacteremia and toxemia as well as nonspecific to mild flu-like symptoms, until the onset of hypotension, shock, and mortality. Without treatment, the mortality rate approaches 100%. Antibi…