Ayshah Aysh ALrashidi
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View article: In Vitro antiproliferative potential of essential oil extract from Carica papaya L. seeds against cervical cancer
In Vitro antiproliferative potential of essential oil extract from Carica papaya L. seeds against cervical cancer Open
Introduction Cervical cancer, the third most common cancer worldwide, is primarily caused by human papillomavirus (HPV) infection. This study aimed to develop natural extracts from the seeds of Carica papaya L. using the hydrodistillation …
View article: Genome-wide identification of potassium transporters and channels in Malus domestica genome
Genome-wide identification of potassium transporters and channels in Malus domestica genome Open
Potassium (K+) is an essential nutrient for plants. It contributes to most physiological and biochemical pathways for plant metabolism, growth, and development. It is the most available plant nutrient, comprising 10-15% of plant…
View article: Syringic Acid Alleviates Doxorubicin-Induced Hepatotoxicity Through PI3K/Akt-Mediated Nrf-2/HO-1 Signaling Pathways in Male Rats
Syringic Acid Alleviates Doxorubicin-Induced Hepatotoxicity Through PI3K/Akt-Mediated Nrf-2/HO-1 Signaling Pathways in Male Rats Open
Syringic acid (SYA) is a significant phenolic compound with the potential for various biomedical uses, including uses of its hepatoprotective properties. Doxorubicin (DOX) is a drug used in the treatment of several tumors, but its side eff…
View article: EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids
EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids Open
Concerning the structural analysis and optimization of various potential EGFR inhibitors. A series of heterocyclic compounds incorporating pyridine, 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole were successfully synthesized via a clic…
View article: Arbuscular mycorrhizal fungi symbiosis enhances growth, nutrient uptake, and oil quality in sunflower–pumpkin under intercropping systems
Arbuscular mycorrhizal fungi symbiosis enhances growth, nutrient uptake, and oil quality in sunflower–pumpkin under intercropping systems Open
Introduction This study evaluated the effects of Funneliformis mosseae , an arbuscular mycorrhizal (AM) fungus, on nutrient uptake, biomass production, and oil quality in sunflower ( Helianthus annuus ) and pumpkin ( Cucurbita pepo ) under…
View article: Investigating the Antioxidant and Anti-Cancer Properties of Milk Thistle Extract Against the HepG2 Cells
Investigating the Antioxidant and Anti-Cancer Properties of Milk Thistle Extract Against the HepG2 Cells Open
Background: Hepatocellular carcinoma (HCC) is the third among all cancer-related causes of death worldwide. The primary cause of HCC development is oxidative stress. Milk thistle (MT) contains numerous phytochemicals that contain antioxida…
View article: Protective Effects of Isolated Curcumin From <i>Curcuma longa</i> on Key Enzymes Involved in the Insulin Signaling Pathway and Digestive and Metabolic Enzymes Associated With Obesity, Type 2 Diabetes, and Hypertension
Protective Effects of Isolated Curcumin From <i>Curcuma longa</i> on Key Enzymes Involved in the Insulin Signaling Pathway and Digestive and Metabolic Enzymes Associated With Obesity, Type 2 Diabetes, and Hypertension Open
This study explores the potential of curcumin (CUR), extracted from Curcuma longa , in combating obesity and Type 2 diabetes. Obesity and Type 2 diabetes were induced in rats through a high‐fat and high‐fructose diet (HFFD), and CUR, after…
View article: Cyanoethyl cellulose–based molecularly imprinted polymer for selective S-suprofen recognition
Cyanoethyl cellulose–based molecularly imprinted polymer for selective S-suprofen recognition Open
View article: Selenium and potassium supplementation improve nitrogen metabolism, antioxidant activity, and osmolyte production, reducing the growth and photosynthetic inhibition caused by polyethylene glycol (PEG) in wheat
Selenium and potassium supplementation improve nitrogen metabolism, antioxidant activity, and osmolyte production, reducing the growth and photosynthetic inhibition caused by polyethylene glycol (PEG) in wheat Open
Drought stress has a significant impact on all crops, affecting both their growth and development. In this study, wheat plants were subjected to drought stress induced by 15% of PEG along with or without supplementation of selenium and pot…
View article: Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats
Syzygium aromaticum Extract Mitigates Doxorubicin-Induced Hepatotoxicity in Male Rats Open
Doxorubicin (DOX), an anticancer drug, is used to treat several types of tumors, but it has detrimental side effects that restrict its therapeutic efficacy. One is the iron-dependent form of ferroptosis, which is characterized by elevated …
View article: Camellia sinensis methanolic leaves extract: Phytochemical analysis and anticancer activity against human liver cancer cells
Camellia sinensis methanolic leaves extract: Phytochemical analysis and anticancer activity against human liver cancer cells Open
Background The study’s primary goal is to ascertain whether there is a relationship between the processed green tea methanolic extract’s (GTME) phytochemical components and its potential effectiveness against human liver cancer cells. The …
View article: Insights into TLC Profiling, Preliminary Phytochemical Screening, Molecular Docking & Antibacterial Activity of Flavonoid Rich Fraction of Haloxylon persicum
Insights into TLC Profiling, Preliminary Phytochemical Screening, Molecular Docking & Antibacterial Activity of Flavonoid Rich Fraction of Haloxylon persicum Open
View article: Jasmonic acid priming and foliar application of spermidine up-regulates the tolerance mechanisms to alleviate the damaging effects of cadmium stress on growth and photosynthesis in wheat
Jasmonic acid priming and foliar application of spermidine up-regulates the tolerance mechanisms to alleviate the damaging effects of cadmium stress on growth and photosynthesis in wheat Open
The study examined the effects of jasmonic acid (100 nmol, JA) priming and foliar application of spermidine (1 mM, Spd), both individually and combined, on mitigating cadmium (100 µM, Cd) stress-induced oxidative damage in wheat. Cadmium s…
View article: Thymus musilii Velen. Methanolic Extract: In Vitro and In Silico Screening of Its Antimicrobial, Antioxidant, Anti-Quorum Sensing, Antibiofilm, and Anticancer Activities
Thymus musilii Velen. Methanolic Extract: In Vitro and In Silico Screening of Its Antimicrobial, Antioxidant, Anti-Quorum Sensing, Antibiofilm, and Anticancer Activities Open
Thymus musilii Velen. is a rare plant species cultivated in the Ha’il region (Saudi Arabia) under greenhouse conditions. In this work, we described, for the first time, the phytochemical composition, antimicrobial, antioxidant, anti-quorum…
View article: Phytotoxic effects of <i>Acacia saligna</i> dry leachates on germination, seedling growth, photosynthetic performance, and gene expression of economically important crops
Phytotoxic effects of <i>Acacia saligna</i> dry leachates on germination, seedling growth, photosynthetic performance, and gene expression of economically important crops Open
The influence of dry leachates of Acasia saligna was tested on the seedling growth, photosynthesis, biochemical attributes, and gene expression of the economically important crops, including wheat ( Triticum aestivum L.), radish ( Raphanus…
View article: Alleviation of salinity triggered oxidative damage and photoinhibition in Vigna radiata by individual and combined treatments of selenium and jasmonic acid
Alleviation of salinity triggered oxidative damage and photoinhibition in Vigna radiata by individual and combined treatments of selenium and jasmonic acid Open
Experiments were performed to evaluate the effect of selenium (Se) and methyl jasmonate (Me-JA) in alleviating the salinity (100 mM NaCl) stress triggered decline in growth and photosynthetic in Vigna radiata. Salinity stress significantly…
View article: Role of calcium and magnesium on dramatic physiological and anatomical responses in tomato plants
Role of calcium and magnesium on dramatic physiological and anatomical responses in tomato plants Open
Minerals are the fundamental source of nutrients for plant functions such as photosynthesis, ATP currency, cellular respiration, metabolic activities, defense mechanisms, and tolerance to biotic and abiotic stressors. Minerals are the most…
View article: Chemical Composition, Antibacterial and Anti-Quorum Sensing Activities of Pimenta dioica L. Essential Oil and Its Major Compound (Eugenol) against Foodborne Pathogenic Bacteria
Chemical Composition, Antibacterial and Anti-Quorum Sensing Activities of Pimenta dioica L. Essential Oil and Its Major Compound (Eugenol) against Foodborne Pathogenic Bacteria Open
The Pimenta dioica essential oil and its main compound (eugenol) were tested for their antibacterial potency against eight Gram-negative and Gram-positive bacteria implicated in food intoxication. This essential oil and its main component …
View article: Phytochemical Profiling of Allium subhirsutum L. Aqueous Extract with Antioxidant, Antimicrobial, Antibiofilm, and Anti-Quorum Sensing Properties: In Vitro and In Silico Studies
Phytochemical Profiling of Allium subhirsutum L. Aqueous Extract with Antioxidant, Antimicrobial, Antibiofilm, and Anti-Quorum Sensing Properties: In Vitro and In Silico Studies Open
The present study was the first to evaluate the phytochemical composition, antioxidant, antimicrobial, antibiofilm, and anti-quorum sensing potential of Allium subhirsutum L. (hairy garlic) aqueous extract through in vitro and in silico st…
View article: Effects of EDTA and aqueous plants extract on the developmental and stress tolerance attributes of Spinacia oleracea and Brassica rapa under sewage water regime
Effects of EDTA and aqueous plants extract on the developmental and stress tolerance attributes of Spinacia oleracea and Brassica rapa under sewage water regime Open
Sewage water is causing a potential threat to agriculture sector due to industrial effluents having heavy metals. Present investigation was carried to study the role of ethylenediaminetetraacetic acid (EDTA) or aqueous extracts of Hyacinth…
View article: Assessment of the R2R3 MYB gene expression profile during tomato fruit development using in silico analysis, quantitative and semi-quantitative RT-PCR
Assessment of the R2R3 MYB gene expression profile during tomato fruit development using in silico analysis, quantitative and semi-quantitative RT-PCR Open
Assessment of gene expression is an essential and sensitive indicator of the biological activity and function of a certain gene. The expression profile of R2R3 MYB gene (Solyc02g067760) was investigated at ten development stages of tomato …
View article: Tripeptides from Allium subhirsitum L. extracts: Pharmacokinetics properties, toxicity prediction and in silico study against SARS-CoV-2 enzymes and pro-inflammatory proteins
Tripeptides from Allium subhirsitum L. extracts: Pharmacokinetics properties, toxicity prediction and in silico study against SARS-CoV-2 enzymes and pro-inflammatory proteins Open
Developing new prophylactic and therapeutic agents with broad-spectrum antiviral activities is urgently needed to combat emerging human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since no available clinically antiviral d…
View article: Emergence, evolution, and vaccine production approaches of SARS-CoV-2 virus: Benefits of getting vaccinated and common questions
Emergence, evolution, and vaccine production approaches of SARS-CoV-2 virus: Benefits of getting vaccinated and common questions Open
The emergence of coronavirus disease 2019 (COVID-19) pandemic in Wuhan city, China at the end of 2019 made it urgent to identify the origin of the causal pathogen and its molecular evolution, to appropriately design an effective vaccine. T…
View article: Exogenous Myo-Inositol Alleviates Salt Stress by Enhancing Antioxidants and Membrane Stability via the Upregulation of Stress Responsive Genes in Chenopodium quinoa L.
Exogenous Myo-Inositol Alleviates Salt Stress by Enhancing Antioxidants and Membrane Stability via the Upregulation of Stress Responsive Genes in Chenopodium quinoa L. Open
Myo-inositol has gained a central position in plants due to its vital role in physiology and biochemistry. This experimental work assessed the effects of salinity stress and foliar application of myo-inositol (MYO) on growth, chlorophyll c…