Ayshamgul Hasim
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View article: Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal Open
By integrating spatial multi-omics with rational nanocarrier design, we designed a glutamine-functionalized liposomal system that exploits ASCT2 overexpression for tumor-selective accumulation of LND. Our findings revealed that this nanoag…
View article: Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma
Metabolism and spatial transcription resolved heterogeneity of glutamine metabolism in cervical carcinoma Open
This finding suggests that the variation in glutamine metabolism is not uniform throughout the tumor. The differential expression of ASCT2 in different regions of cervical cancer tissues seems to play a key role in causing this heterogenei…
View article: Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of <scp>RACK1</scp>‐mediated fatty acid synthesis
Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of <span>RACK1</span>‐mediated fatty acid synthesis Open
Lipid metabolism is altered in rapidly proliferating cancer cells, where fatty acids (FAs) are utilized in the synthesis of sphingolipids and glycerophospholipids to produce cell membranes and signaling molecules. Receptor for activated C‐…
View article: Local membrane source gathering by p62 body drives autophagosome formation
Local membrane source gathering by p62 body drives autophagosome formation Open
Autophagosomes are double-membrane vesicles generated intracellularly to encapsulate substrates for lysosomal degradation during autophagy. Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlyin…
View article: Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis‑dependent AKT/mTOR signaling
Receptor for activated C kinase 1 promotes cervical cancer lymph node metastasis via the glycolysis‑dependent AKT/mTOR signaling Open
Cervical cancer (CC), an aggressive form of squamous cell carcinoma, is characterized by early‑stage lymph node metastasis and an extremely poor prognosis. The authors have previously demonstrated that patients with CC have aberrant glycol…
View article: CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways Open
Persistent infection with human papillomavirus (HPV) and immune surveillance failure may be the initiating factors for the carcinogenesis of cervical squamous cell carcinoma (CSCC). HPV infection might affect the innate immune pathway of c…
View article: Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer
Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer Open
Background To validate markers for cervical carcinoma (CC) and precancerous lesions related with HPV infections. Methods Three different cervical cancer cell lines C-33A, SiHa and Caski were used for secretome profiling by label-free quant…
View article: Additional file 9 of Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer
Additional file 9 of Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer Open
Additional file 9: Table S7.
View article: Additional file 1 of Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer
Additional file 1 of Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer Open
Additional file 1: Table S1.
View article: Overexpression of GNB2L1 is associated with poor prognosis in cervical cancer patients
Overexpression of GNB2L1 is associated with poor prognosis in cervical cancer patients Open
Background: Among women, cervical cancer (CC) is the fourth most prevalent cancer worldwide. Multiple bio-makers have been identified for tumor diagnosis and prognosis. However, no single bio-maker for CC detection exists that is both high…
View article: CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression.
CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression. Open
CD147 is a transmembrane glycoprotein that when highly expressed contributes to tumor progression. In the present study, we investigate the clinical relevance of CD147 expression in CCSC tissues and evaluate the association between CD147 e…
View article: Clinical efficacy of levonorgestrel releasing intrauterine system for the treatment of adenomyosis in perimenopausal women
Clinical efficacy of levonorgestrel releasing intrauterine system for the treatment of adenomyosis in perimenopausal women Open
Background: The aim of this study was to evaluate the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of menorrhagia, dysmenorrhea, and poor quality of life caused by adenomyosis in perimenopausal women.…
View article: High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma
High MLL2 expression predicts poor prognosis and promotes tumor progression by inducing EMT in esophageal squamous cell carcinoma Open
View article: RNF113A promotes the proliferation, migration and invasion, and is associated with a poor prognosis of esophageal squamous cell carcinoma
RNF113A promotes the proliferation, migration and invasion, and is associated with a poor prognosis of esophageal squamous cell carcinoma Open
Ring finger protein 113A (RNF113A) possesses a C3HC4 zinc finger domain and this domain is found in E3 ubiquitin ligase and is involved in tumorigenesis. To date, and at least to the best of our knowledge, there are no studies available wh…
View article: Over-expression of prolyl isomerase Pin1 promotes cervical tumorigenesis and metastasis.
Over-expression of prolyl isomerase Pin1 promotes cervical tumorigenesis and metastasis. Open
Overexpression of the prolyl isomerase PIN1 is involved in tumorigenesis, but the role of PIN1 in cervical cancer is unclear. In this study, we examined PIN1 protein expression by immunohistochemistry in 221 paraffin-embedded samples from …
View article: Partition-Defective 3 (PARD3) Regulates Proliferation, Apoptosis, Migration, and Invasion in Esophageal Squamous Cell Carcinoma Cells
Partition-Defective 3 (PARD3) Regulates Proliferation, Apoptosis, Migration, and Invasion in Esophageal Squamous Cell Carcinoma Cells Open
BACKGROUND Altered expression of partition-defective 3 (PARD3), a polarity-related gene associated with oncogenesis, has been identified in some cancers, but the role of PARD3 in esophageal squamous cell carcinoma (ESCC) remains unclear. M…
View article: Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang
Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang Open
Thsd7a (Thrombospondin type 1 domain containing 7a) is a critical transmembrane protein. Studies have indicated that Thsd7a was associated with cytoskeletal organization, cell migration and filopodia formation. However, the involvement of …
View article: The Effects of Aqueous Extract from <i>Nardostachys chinensis</i> Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats
The Effects of Aqueous Extract from <i>Nardostachys chinensis</i> Batalin on Blood Pressure and Cardiac Hypertrophy in Two‐Kidney One‐Clip Hypertensive Rats Open
Aims . The aim of this study was to investigate the effects of the aqueous extract of Nardostachys chinensis Batalin (NCBAE) on blood pressure and cardiac hypertrophy using two‐kidney one‐clip (2K1C) hypertensive rats. Methods . 2K1C rat m…
View article: Quantitative analysis of Keap1 gene single CpG site methylation by Sequenom MassARRAY.
Quantitative analysis of Keap1 gene single CpG site methylation by Sequenom MassARRAY. Open
Quantitative analysis of Keap1 gene single CpG site methylation by Sequenom MassARRAY.
View article: The origins of Uyghur medicine: Debates and perspectives
The origins of Uyghur medicine: Debates and perspectives Open
Uyghur medicine refers to the traditional medicine of the people residing in the oases of the Taklamakan desert in the North-West corner of modern China. Due to historical and geographical reasons, the ancestors of the modern Uyghurs had e…
View article: Functional Role of NRF2 in Cervical Carcinogenesis
Functional Role of NRF2 in Cervical Carcinogenesis Open
Nuclear factor erythroid-2-related factor 2 (NFE2L2) is a transcription factor associated with resistance to chemotherapy and increased tumor growth. NRF2 is repressed by the inhibitor Keap1. The Keap1-NRF2 pathway is dysfunctional in mult…
View article: Epigenetic Changes within the Promoter Regions of Antigen Processing Machinery Family Genes in Kazakh Primary Esophageal Squamous Cell Carcinoma
Epigenetic Changes within the Promoter Regions of Antigen Processing Machinery Family Genes in Kazakh Primary Esophageal Squamous Cell Carcinoma Open
The esophageal squamous cell carcinoma (ESCC) is thought to develop through a multi-stage process. Epigenetic gene silencing constitutes an alternative or complementary mechanism to mutational events in tumorigenesis. Posttranscriptional r…