Ayumi Kashiro
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View article: Platform of single-molecule enzyme activity-based liquid biopsy for detection of pancreatic adenocarcinoma at early stages
Platform of single-molecule enzyme activity-based liquid biopsy for detection of pancreatic adenocarcinoma at early stages Open
Liquid biopsy analyzes biomolecules in biofluids to provide critical information for the early detection of diseases and the development of more effective treatment strategies. Among these biomolecules, the functional states of proteins of…
View article: Risk Stratification for Malignant Potential of Intraductal Papillary Mucinous Neoplasms Using the Apolipoprotein-A2 Isoforms Blood Test
Risk Stratification for Malignant Potential of Intraductal Papillary Mucinous Neoplasms Using the Apolipoprotein-A2 Isoforms Blood Test Open
INTRODUCTION: High-risk stigmata (HRS) and worrisome features (WFs) are imaging findings that reflect malignant potential of intraductal papillary mucinous neoplasms (IPMNs). The aim of this study was to determine the potential utility of …
View article: From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform
From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform Open
Pancreatic cancer is a rare and refractory cancer, and the development of blood biomarkers for the enrichment of high-risk individuals who have risk factors for pancreatic cancer from the asymptomatic population is an unmet medical need. W…
View article: Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer
Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer Open
Background We have previously reported apolipoprotein A2-isoforms (apoA2-is) as candidate plasma biomarkers for early-stage pancreatic cancer. The aim of this study was the clinical development of apoA2-is. Methods We established a new enz…
View article: Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening
Identification of activity-based biomarkers for early-stage pancreatic tumors in blood using single-molecule enzyme activity screening Open
Single-molecule enzyme activity-based enzyme profiling (SEAP) is a methodology to globally analyze protein functions in living samples at the single-molecule level. It has been previously applied to detect functional alterations in phospha…
View article: Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis Open
We revealed higher neurolysin activity in the blood samples of patients with colorectal tumors, indicating that single-molecule neurolysin activity is a promising candidate for a blood biomarker for colorectal cancer diagnosis.
View article: <i>Alpha‐actinin‐4 (ACTN4)</i> gene amplification is a predictive biomarker for adjuvant chemotherapy with tegafur/uracil in stage I lung adenocarcinomas
<i>Alpha‐actinin‐4 (ACTN4)</i> gene amplification is a predictive biomarker for adjuvant chemotherapy with tegafur/uracil in stage I lung adenocarcinomas Open
Although adjuvant tegafur/uracil (UFT) is recommended for patients with completely resected stage I non‐small‐cell lung cancer (NSCLC) in Japan, only one‐third of cases has received adjuvant chemotherapy (ADJ) according to real‐world data.…
View article: Noninvasive risk stratification of intraductal papillary mucinous neoplasia with malignant potential by serum <scp>apolipoprotein‐A2</scp>‐isoforms
Noninvasive risk stratification of intraductal papillary mucinous neoplasia with malignant potential by serum <span>apolipoprotein‐A2</span>‐isoforms Open
Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions of pancreatic cancer. An accurate serum biomarker, which allows earlier identification of asymptomatic individuals with high‐risk for developing cancer, is of urgent…
View article: P8‐1: Differential expression of miR‐375 and miR‐455‐3p is related to molecular subtyping of small cell lung cancer
P8‐1: Differential expression of miR‐375 and miR‐455‐3p is related to molecular subtyping of small cell lung cancer Open
Background and Aims: Development of adult respiratory disease is influenced by events in childhood.Early life exposure to respiratory diseases is associated with lung impairment in adulthood.The objective of this study was to investigate w…
View article: O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer
O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer Open
Pancreatic cancer (PC) is among the most lethal malignancies due to an often delayed and difficult initial diagnosis. Therefore, the development of a novel, early stage, diagnostic PC marker in liquid biopsies is of great significance. In …
View article: Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology
Prospects for Comprehensive Analyses of Circulating Tumor Cells in Tumor Biology Open
The comprehensive analysis of biological and clinical aspects of circulating tumor cells (CTCs) has attracted interest as a means of enabling non-invasive, real-time monitoring of cancer patients and enhancing our fundamental understanding…