Anupam Sinha
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View article: Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis Open
Background Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood. Methods We u…
View article: A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity Open
Altogether, we identified AZIN2 as a novel AP marker that regulates AP fate and preserves adipose tissue health.
View article: ACOD1 regulates microglial arginine metabolism and inflammatory responses
ACOD1 regulates microglial arginine metabolism and inflammatory responses Open
Itaconate is produced by inflammatory macrophages and promotes a negative feedback on inflammation. It is synthesized by aconitate decarboxylase 1 (ACOD1) from cis- aconitate, a metabolite of the tricarboxylic acid cycle. Here, we studied …
View article: Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis Open
Glucocorticoids regulate hematopoiesis, but how chronic elevation of endogenous glucocorticoid production affects hematopoietic stem cell (HSC) function and immune cell development remains incompletely understood. Using an adrenocortical c…
View article: AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism
AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism Open
Summary Adipose tissue homeostasis plays a critical role in metabolic disease but the metabolic circuitry regulating adipose tissue dynamics remains unclear. In this study, polyamine metabolism emerges as an important regulator of adipose …
View article: Endoglin regulates the integrity of the bone marrow vasculature
Endoglin regulates the integrity of the bone marrow vasculature Open
Endoglin (Eng) is an accessory receptor for transforming growth factor-β (TGF-β) that is critical for maintaining vascular integrity. Mutations in Eng cause hereditary hemorrhagic telangiectasia (HHT), resulting in arteriovenous malformati…
View article: CD38 promotes hematopoietic stem cell dormancy
CD38 promotes hematopoietic stem cell dormancy Open
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs. The state of dormancy protects the HSC pool from exhaustion th…
View article: Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland
Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland Open
Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospho…
View article: Succinate mediates inflammation-induced adrenocortical dysfunction
Succinate mediates inflammation-induced adrenocortical dysfunction Open
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, s…
View article: Alterations in the hepatocyte epigenetic landscape in steatosis
Alterations in the hepatocyte epigenetic landscape in steatosis Open
Fatty liver disease or the buildup of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known abo…
View article: CD38 promotes hematopoietic stem cell dormancy via c-Fos
CD38 promotes hematopoietic stem cell dormancy via c-Fos Open
A subpopulation of deeply quiescent, so-called dormant hematopoietic stem cells (dHSCs) resides at the top of the hematopoietic hierarchy and serves as a reserve pool for HSCs possessing the greatest long-term blood repopulation capacity. …
View article: Circulating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19
Circulating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19 Open
Context and aims Coronavirus disease 19 (COVID-19) trajectories show high interindividual variability, ranging from asymptomatic manifestations to fatal outcomes, the latter of which may be fueled by immunometabolic maladaptation of the ho…
View article: Succinate mediates inflammation-induced adrenocortical dysfunction
Succinate mediates inflammation-induced adrenocortical dysfunction Open
The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, s…
View article: The RNA binding protein human antigen R is a gatekeeper of liver homeostasis
The RNA binding protein human antigen R is a gatekeeper of liver homeostasis Open
Background and Aims NAFLD is initiated by steatosis and can progress through fibrosis and cirrhosis to HCC. The RNA binding protein human antigen R (HuR) controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in…
View article: HIF2α is a direct regulator of neutrophil motility
HIF2α is a direct regulator of neutrophil motility Open
Orchestrated recruitment of neutrophils to inflamed tissue is essential during the initiation of inflammation. Inflamed areas are usually hypoxic, and adaptation to reduced oxygen pressure is typically mediated by hypoxia pathway proteins.…
View article: HIF1α is a direct regulator of steroidogenesis in the adrenal gland
HIF1α is a direct regulator of steroidogenesis in the adrenal gland Open
Endogenous steroid hormones, especially glucocorticoids and mineralocorticoids, derive from the adrenal cortex, and drastic or sustained changes in their circulatory levels affect multiple organ systems. Although hypoxia signaling in stero…
View article: Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine
Exhaled breath compositions under varying respiratory rhythms reflects ventilatory variations: translating breathomics towards respiratory medicine Open
Control of breathing is automatic and its regulation is keen to autonomic functions. Therefore, involuntary and voluntary nervous regulation of breathing affects ventilatory variations, which has profound potential to address expanding cha…
View article: HIF1α is an essential regulator of steroidogenesis in the adrenal gland
HIF1α is an essential regulator of steroidogenesis in the adrenal gland Open
Endogenous steroid hormones, especially glucocorticoids and mineralocorticoids, are essential for life regulating numerous physiological and pathological processes. These hormones derive from the adrenal cortex, and drastic or sustained ch…
View article: HIF2α is a Direct Regulator of Neutrophil Motility
HIF2α is a Direct Regulator of Neutrophil Motility Open
Orchestrated recruitment of neutrophils to inflamed tissue is essential during initiation of inflammation. Inflamed areas are usually hypoxic, and adaptation to reduced oxygen pressure is typically mediated by hypoxia pathway proteins. How…
View article: A bipartite element with allele-specific functions safeguards DNA methylation imprints at the<i>Dlk1-Dio3</i>locus
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the<i>Dlk1-Dio3</i>locus Open
SUMMARY Dysregulation of imprinted gene loci also referred to as loss of imprinting (LOI) can result in severe developmental defects and other diseases, but the molecular mechanisms that ensure imprint stability remain incompletely underst…
View article: The significance of urgent ultrasound scan for shoulder dislocation in patients above the age of 40: A prospective British Elbow and Shoulder Society pathway implementation study
The significance of urgent ultrasound scan for shoulder dislocation in patients above the age of 40: A prospective British Elbow and Shoulder Society pathway implementation study Open
Background The highlight of the British Elbow and Shoulder Society pathway for the management of traumatic anterior shoulder instability is early imaging in patients aged over 40 years to assess rotator cuff integrity and early repair, if …
View article: Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases
Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases Open
Key Points A dual signal from c-Kit and VEGFR-2 determines selective activation of HSCs and MPP2 in response to acute immune thrombocytopenia. VEGF-A and PDGF-BB relocalize stem cell factor in megakaryocytes, triggering proliferation of HS…