Azizeh Asadzadeh
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View article: Human Papillomavirus, Deregulated Micro Ribonucleic Acids, and Long Non-coding Ribonucleic Acids in Cervical Cancer Patients: A Review Study
Human Papillomavirus, Deregulated Micro Ribonucleic Acids, and Long Non-coding Ribonucleic Acids in Cervical Cancer Patients: A Review Study Open
Cervical cancer (CC) ranks fourth in incidence and is one of the most serious global health problems. Infection with high-risk human papillomaviruses (hrHPV), including types 16 and 18, plays a significant role in the occurrence of this ty…
View article: Predicting interactome networks of up/down regulated proteins and drug-gene interaction analysis associated with peri-implantitis
Predicting interactome networks of up/down regulated proteins and drug-gene interaction analysis associated with peri-implantitis Open
Background: Peri-implantitis is implant-associated inflammation that leads to irreversible loss of surrounding bone. Early diagnosis increases the success of peri-implantitis treatment. Despite various studies associated with this most com…
View article: Antifungal potential of the main compounds of Cuminum cyminum L. in targeting secreted aspartyl proteinase of Candida albicans compared to fluconazole
Antifungal potential of the main compounds of Cuminum cyminum L. in targeting secreted aspartyl proteinase of Candida albicans compared to fluconazole Open
View article: Designing a novel multi-epitope chimeric vaccine candidate for human papillomavirus by vaccinomic approach
Designing a novel multi-epitope chimeric vaccine candidate for human papillomavirus by vaccinomic approach Open
Designing a novel multi-epitope chimeric vaccine candidate for human papillomavirus by vaccinomic approach
View article: In silico prediction of differentially expressed genes and functionally grouped networks in patients with inflamed pulp for screening pulpitis biomarkers
In silico prediction of differentially expressed genes and functionally grouped networks in patients with inflamed pulp for screening pulpitis biomarkers Open
In our research, 15 genes were introduced as diagnostic biomarkers in pulpitis and their functionally grouped networks were constructed. However, the obtained results need to be validated using in vitro and in vivo methods.
View article: Identification of druggable hub genes and key pathways associated with cervical cancer by protein-protein interaction analysis: An in silico study
Identification of druggable hub genes and key pathways associated with cervical cancer by protein-protein interaction analysis: An in silico study Open
Background: The uncontrolled growth of abnormal cells in the cervix leads to cervical cancer (CC), the fourth most common gynecologic cancer. So far, many studies have been conducted on CC; however, it is still necessary to discover the hu…
View article: Studying the Inhibitory Effects of Some Chalcone Derivatives on <i>Streptococcus mutans</i> Sortase A to Prevent Dental Caries: An In Silico Approach
Studying the Inhibitory Effects of Some Chalcone Derivatives on <i>Streptococcus mutans</i> Sortase A to Prevent Dental Caries: An In Silico Approach Open
Background: Streptococcus mutans is one of the most important microorganisms in tooth decay. Sortase A (SrtA) of S. mutans is responsible for the attachment of bacteria to the host cell and biofilm formation. Therefore, it seems necessary …
View article: Design of a multi-epitope vaccine using HA and M1 proteins from influenza and S, E, and M proteins from SARS-CoV-2 by in silico tools
Design of a multi-epitope vaccine using HA and M1 proteins from influenza and S, E, and M proteins from SARS-CoV-2 by in silico tools Open
Among various infections, acute respiratory tract infections (ARTIs) have the highest incidence and mortality in the world. These infections are caused by various microorganisms such as the influenza and SARS-CoV-2 viruses. The potential e…
View article: Designing Multi‐Epitope Subunit Vaccine Candidate for Zika Virus Utilizing In silico Tools
Designing Multi‐Epitope Subunit Vaccine Candidate for Zika Virus Utilizing In silico Tools Open
Background: The arboviruses Zika virus (ZIKV) is a pathogen that threatens human health. Scientists have warned that a single mutation in the mosquito-borne ZIKV could spark another major outbreak of the disease in humans. Therefore, desig…
View article: study the effect of thymus vulgaris in inhibiting acetylcholinesterase enzyme in order to treat Alzheimer’s disease
study the effect of thymus vulgaris in inhibiting acetylcholinesterase enzyme in order to treat Alzheimer’s disease Open
Introduction: Alzheimer’s disease is the most common cause of dementia in the elderly and is characterized by loss of memory and other cognitive functions. The acetylcholinesterase enzyme (ACHE) with hydrolysis of the neurotransmitter acet…
View article: Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population.
Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population. Open
The L allele of 5-HTTLPR was related to the increased serum lipids and blood pressure in the diabetic patients. However, there was no relationship between the polymorphism of 5-HTTLPR L/S and T2DM in Iranian population.
View article: Docking Study on salicylaldehyde Derivatives as Anti-melanogenesis Agents
Docking Study on salicylaldehyde Derivatives as Anti-melanogenesis Agents Open
Background & Objective: Abnormal production of melanin pigment which causes melasma, freckles, ephelides, and age spots, are esthetic problems. Polyphenol oxidase (PPO), a copper-containing enzyme, is involved in melanin biosynthesis and t…
View article: Molecular Docking Studies of Some Hydroxy Nitrodiphenyl Ether Analogues as Tyrosinase Inhibitors
Molecular Docking Studies of Some Hydroxy Nitrodiphenyl Ether Analogues as Tyrosinase Inhibitors Open
Background & Objective: Tyrosinase is a key enzyme in pigment synthesis.Overproduction of melanin in parts of the skin results in hyperpigmentation diseases. Thus, its inhibitors are highly important in the medical, cosmetic and agricultur…
View article: In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme.
In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme. Open
Based on the docking studies, from the twelve compounds studied, one (IIId) appeared to have the highest inhibition on tyrosinase activity. This was confirmed by enzyme activity measurements. Compound IIId has an NO2 group which binds to b…
View article: Docking Studies of Some Novel Kojic acid Derivatives as Possible Tyrosinase Inhibitors
Docking Studies of Some Novel Kojic acid Derivatives as Possible Tyrosinase Inhibitors Open
Introduction Tyrosinase is copper-dependent enzyme that catalyze the oxidations of both monophenols and o-diphenols into reactive o-quinones (1-4). Melanin synthesis is initiated from tyrosine by tyrosinase. Although melanin is essential f…
View article: In Silico Approach for Designing Potent Inhibitors against Tyrosinase
In Silico Approach for Designing Potent Inhibitors against Tyrosinase Open