Alireza Abadi
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View article: Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities
Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities Open
A novel series of pyrazolidinones and pyrazolidinediones was developed as selective COX-2 inhibitors, exhibiting anti-amyloid β, anti-tau, and neuroprotective activities.
DNA methylation and machine learning: challenges and perspective toward enhanced clinical diagnostics Open
DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large dataset…
Evaluation of Toxoplasma and Toxocara Prevalence in Chronic Kidney Disease (CKD) Patients Using Serologic and Molecular Technique in Selected Medical Centers of Tehran, Iran Open
Background: Toxoplasmosis and toxocariasis are two zoonotic diseases with global impact. Chronic kidney disease (CKD) can lead to complications, associated with reduced immune responses that predispose them to frequent parasitic infections…
View article: Osteotomies: Indications, Imaging Appearance, Surgical Techniques, and Complications
Osteotomies: Indications, Imaging Appearance, Surgical Techniques, and Complications Open
Osteotomies can be performed on almost every bone and are commonly encountered indications for imaging studies. These procedures are employed to correct congenital, degenerative, and traumatic osseous deformities, ultimately improving both…
View article: From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds Open
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) especially in children. The majority of EV-A71 cases are mild, however, severe cases have exhibited an array of neurological complications which of…
Cyclic nucleotide phosphodiesterases as drug targets Open
Cyclic nucleotides are synthesized by adenylyl and/or guanylyl cyclase, and downstream of this synthesis, the cyclic nucleotide phosphodiesterase families (PDEs) specifically hydrolyze cyclic nucleotides. PDEs control cyclic adenosine-3',5…
View article: Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer
Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer Open
Overexpression of histone deacetylase 6 (HDAC6) is implicated in tumorigenesis, invasion, migration, survival, apoptosis, and growth of various malignancies, making it a promising target for cancer treatment.
Inflammatory immune response and its key roles in the process of bone fractures healing Open
Bone fractures, which represent 2% - 5% of adults annually, are considered a significant health concern, particularly as their incidence has recently increased. Bones are composed of minerals such as calcium and phosphate, and organic comp…
Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold Open
CK2 is a Ser/Thr-protein kinase playing a crucial role in promoting cell growth and survival, hence it is considered a promising target for anti-cancer drugs. However, many previously reported CK2 inhibitors lack selectivity. In search of …
View article: Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways
Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways Open
Targeting neutrophil function has gained attention as a propitious therapeutic strategy for diverse inflammatory diseases. Accordingly, a series of enone-based derivatives were developed to inhibit neutrophil-mediated inflammation, showing…
View article: Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability
Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability Open
Dysregulation of the CXCL12/CXCR4 axis is implicated in autoimmune, inflammatory, and oncogenic diseases, positioning CXCR4 as a pivotal therapeutic target. We evaluated optimized variants of the specific endogenous CXCR4 antagonist, EPI-X…
N-Benzylated 5-Hydroxybenzothiophene-2-carboxamides as Multi-Targeted Clk/Dyrk Inhibitors and Potential Anticancer Agents Open
Numerous studies have reported that Dyrk1A, Dyrk1B, and Clk1 are overexpressed in multiple cancers, suggesting a role in malignant disease. Here, we introduce a novel class of group-selective kinase inhibitors targeting Dyrk1A, Dyrk1B, and…
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity Open
Aim: Chemoresistance in cancer challenges the classical therapeutic strategy of 'one molecule-one target'. To combat this, multi-target therapies that inhibit various cancer-relevant targets simultaneously are proposed. Methods & results: …
View article: Bayesian analysis of esophageal cancer mortality in the presence of misclassification
Bayesian analysis of esophageal cancer mortality in the presence of misclassification Open
Background: Esophageal cancer (EC) is one of the most common cancers worldwide. Mortality is a familiar projection that addresses the burden of cancers. With regards to cancer mortality, data are important and used to monitor the effects o…
<i>N</i><sub>1</sub>‐Benzoylated 5‐(4‐pyridinyl)indazole‐based kinase inhibitors: Attaining haspin and Clk4 selectivity via modulation of the benzoyl substituents Open
Haspin and Clk4 are both understudied protein kinases (PKs), offering potential targets for the development of new anticancer agents. Thus, the identification of new inhibitors targeting these PKs is of high interest. However, the inhibito…
Synthesis and evaluation of novel N1-acylated 5-(4-pyridinyl)indazole derivatives as potent and selective haspin inhibitors Open
Protein kinase dysregulation was strongly linked to cancer pathogenesis. Moreover, histone alterations were found to be among the most important post-translational modifications that could contribute to cancer growth and development. In th…
Development and evaluation of 2,4‐disubstituted‐5‐aryl pyrimidine derivatives as antibacterial agents Open
Designing novel candidates as potential antibacterial scaffolds has become crucial due to the lack of new antibiotics entering the market and the persistent rise in multidrug resistance. Here, we describe a new class of potent antibacteria…
Comparison of Toxoplasmosis Seroprevalence in Multi Partner, Married (Monogamous) and Virgin Iranian Women Open
Background: Toxoplasmosis could lead to serious outcomes during pregnancy. The aim of this study was to investigate serologic toxoplasmosis in three groups of women according to number of sexual partners. Methods: The frequency of anti-Tox…
View article: Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability
Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability Open
EPI-X4, a natural peptide CXCR4 antagonist, shows potential for treating inflammation and cancer, but its short plasma stability limits its clinical application. We aimed to improve the plasma stability of EPI-X4 analogues without compromi…
Random-Splitting Random Forest with Multiple Mixed-Data Covariates Open
Introduction:The bagging (BG) and random forest (RF) are famous supervised statistical learning methods based on the classification and regression trees. The BG and RF can deal with different types of responses such as categorical, continu…
Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives Open
Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and pathological processes. Beyond their well-known efficacy in trea…
Structure–Activity Relationships of Triphenylethylene Derivatives and Their Evaluation as Anticancer and Antiviral Agents Open
Tamoxifen (TAM) is a selective estrogen receptor modulator (SERM) that is used in the treatment of breast cancer, yet with the risk of developing uterine cancer. A perfect SERM would act as an estrogen activator on bones, the cardiovascula…
View article: Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease
Novel benzothiazole derivatives as multitargeted-directed ligands for the treatment of Alzheimer’s disease Open
Neurodegenerative diseases such as Alzheimer’s disease (AD) are multifactorial with several different pathologic mechanisms. Therefore, it is assumed that multitargeted-directed ligands (MTDLs) which interact with different biological targ…
Novel 9-Benzylaminoacridine Derivatives as Dual Inhibitors of Phosphodiesterase 5 and Topoisomerase II for the Treatment of Colon Cancer Open
It has been shown that phosphodiesterase 5 (PDE5) inhibitors have anticancer effects in a variety of malignancies in both in vivo and in vitro experiments. The role of cGMP elevation in colorectal carcinoma (CRC) has been extensively studi…
Development of N-terminally modified variants of the CXCR4-antagonizing peptide EPI-X4 with increased plasma stability Open
EPI-X4 is a natural peptide antagonist of CXCR4, an established drug target in inflammatory diseases and cancer. Advanced derivatives of EPI-X4, such as EPI-X4 JM#21, have shown promising therapeutic effects in animal models of CXCR4-assoc…