Joseph Bagi Suleiman
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View article: Assessing Factors Influencing HPV Vaccine Uptake and Hesitancy in Northern Nigeria
Assessing Factors Influencing HPV Vaccine Uptake and Hesitancy in Northern Nigeria Open
Human Papillomavirus (HPV) is a major health issue highly prevalent among participants with most of the victims being women since it is the primary cause of cervical cancer. Although HPV vaccination is recommended by the World Health Organ…
View article: Burden and Distribution of Protozoan Pathogens in Diarrhea Cases Worldwide: A Systematic Review and Meta-Analysis, 1999-2024
Burden and Distribution of Protozoan Pathogens in Diarrhea Cases Worldwide: A Systematic Review and Meta-Analysis, 1999-2024 Open
View article: Genomic Profiling Filtering and Molecular Analysis of Colorectal Cancer (CRC) using Next Generation Sequencing (NGS): Identifying Somatic Mutations Biomarkers and Patterns for Precision Medicine
Genomic Profiling Filtering and Molecular Analysis of Colorectal Cancer (CRC) using Next Generation Sequencing (NGS): Identifying Somatic Mutations Biomarkers and Patterns for Precision Medicine Open
Methods Illumina 52-gene-focus panel using NGS was used to detect crucial mutations associated with CRC using Formalin-Fixed Paraffin-Embedded (FFPE) tissue among 21 patients. FastQ data was generated and used to analyze somatic variants. …
View article: The dual role of extracellular vesicles derived from animal and human immune cells: A systematic review
The dual role of extracellular vesicles derived from animal and human immune cells: A systematic review Open
This review aims to examine the functions of extracellular vesicles (EVs) originating from animal and human immune cells, with a focus on their roles in immunomodulation and therapeutic potential. It highlights their dual effects in infect…
View article: Serum levels of copper and zinc and their relationship with iron status in sickle cell anemia patients
Serum levels of copper and zinc and their relationship with iron status in sickle cell anemia patients Open
Purpose: To determine the serum levels of copper and zinc and their relationship with iron status in patients with sickle cell anemia (SCA). Methods: Sixty-six (66) subjects comprising thirty-five (35) HbSS steady state (SS) and thirty-one…
View article: Therapeutic Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through the Activation of the Keap1/Nrf2 Signaling Pathway in an Obese Rat Model
Therapeutic Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through the Activation of the Keap1/Nrf2 Signaling Pathway in an Obese Rat Model Open
Bee bread (BB) has traditionally been used as a dietary supplement to treat liver problems. This study evaluated the therapeutic effects of Heterotrigona itama BB from Malaysia on obesity-induced hepatic lipid metabolism disorder via the r…
View article: Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats
Orlistat Mitigates Oxidative Stress-Linked Myocardial Damage via NF-κβ- and Caspase-Dependent Activities in Obese Rats Open
Oxidative stress contributes to major complications of obesity. This study intended to identify whether orlistat could mitigate myocardial damage in obese animal models. The tested rats were divided into two groups and fed either with norm…
View article: Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model
Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model Open
Obesity is a debilitating disorder with a variety of problems including oxidative stress, inflammation, and apoptosis. The aim of our study was to investigate the therapeutic role of bee bread on oxidative stress, apoptosis, and inflammati…
View article: Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation
Hepatoprotective Effect of Bee Bread in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Rats: Impact on Oxidative Stress and Inflammation Open
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a pathological accumulation of hepatic lipid closely linked with many metabolic disorders, oxidative stress and inflammation. We aimed to evaluate the hepatoprotective effect …
View article: Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation
Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation Open
Metabolic dysfunction-associated fatty liver disease (MAFLD) is an excessive buildup of liver lipids closely associated with various kinds of undesirable metabolic effects and oxidative stress. We aimed to investigate the protective and th…
View article: Chemical Profile, Antioxidant Properties and Antimicrobial Activities of Malaysian Heterotrigona itama Bee Bread
Chemical Profile, Antioxidant Properties and Antimicrobial Activities of Malaysian Heterotrigona itama Bee Bread Open
The aim of the study was to determine the chemical profile, antioxidant properties and antimicrobial activities of Heterotrigona itama bee bread from Malaysia. The pH, presence of phytochemicals, antioxidant properties, total phenolic cont…
View article: Review on Bee Products as Potential Protective and Therapeutic Agents in Male Reproductive Impairment
Review on Bee Products as Potential Protective and Therapeutic Agents in Male Reproductive Impairment Open
Bee products are sources of functional food that have been used in complementary medicine to treat a variety of acute and chronic illnesses in many parts of the world. The products vary from location to location as well as country to count…
View article: Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway
Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway Open
Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether…
View article: Tert-butylhydroquinone attenuates doxorubicin-induced dysregulation of testicular cytoprotective and steroidogenic genes, and improves spermatogenesis in rats
Tert-butylhydroquinone attenuates doxorubicin-induced dysregulation of testicular cytoprotective and steroidogenic genes, and improves spermatogenesis in rats Open
View article: Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model
Anti-Atherogenic Effects of Orlistat on Obesity-Induced Vascular Oxidative Stress Rat Model Open
Obesity is typically linked to oxidative stress and inflammation, which lead to vascular damage and initiate the progression of atherosclerosis. The aim of this study was to determine the anti-atherosclerotic effect of orlistat on obesity-…
View article: Protective effects of bee bread on testicular oxidative stress, NF-κB-mediated inflammation, apoptosis and lactate transport decline in obese male rats
Protective effects of bee bread on testicular oxidative stress, NF-κB-mediated inflammation, apoptosis and lactate transport decline in obese male rats Open
Oxidative stress, chronic inflammation and apoptosis are associated with obesity. Herein, we investigated the potential protective effect of bee bread, a natural bee product, on testicular oxidative stress, inflammation and apoptosis, as w…
View article: Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats
Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats Open
Obesity and its accompanying complications predispose to abnormal testicular glucose metabolism, penile erectile dysfunction and subfertility. This study examined the potentials of orlistat in attenuating erectile dysfunction and fertility…
View article: Role of heterotrigona itama bee bread on reproductive system in male rats fed with high-fat diet
Role of heterotrigona itama bee bread on reproductive system in male rats fed with high-fat diet Open
Obesity has been reported to cause testicular oxidative stress, inflammation and
\napoptosis thereby resulting in impaired male reproductive function while bee bread,
\non the other hand, exhibits antioxidant, anti-inflammatory and anti-ap…
View article: Orlistat attenuates obesity‐induced decline in steroidogenesis and spermatogenesis by up‐regulating steroidogenic genes
Orlistat attenuates obesity‐induced decline in steroidogenesis and spermatogenesis by up‐regulating steroidogenic genes Open
Background Steroidogenesis decline is reported to be one of the mechanisms associated with obesity‐induced male factor subfertility/infertility. Objectives We explored the possible preventive/therapeutic effects of orlistat (a medication p…
View article: A systematic review on different models of inducing obesity in animals: Advantages and limitations
A systematic review on different models of inducing obesity in animals: Advantages and limitations Open
Several animals have been in the limelight of basic research associated with metabolic diseases like obesity. Obesity can be considered as a significant public health concern in the world. It raises the chances for a variety of disease con…
View article: Malaysian propolis and metformin mitigate subfertility in streptozotocin‐induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour
Malaysian propolis and metformin mitigate subfertility in streptozotocin‐induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour Open
Background Diabetes mellitus is one of the risk factors for male subfertility/infertility. Malaysian propolis is reported to decrease hyperglycaemia in diabetic state. Objectives The present study investigated the protective effect of Mala…
View article: Malaysian Bee Bread Attenuates Apoptosis and Improves Cell Proliferation in Testis of High-Fat Diet-Induced Obese Rats
Malaysian Bee Bread Attenuates Apoptosis and Improves Cell Proliferation in Testis of High-Fat Diet-Induced Obese Rats Open
Introduction: Obesity has been reported to impair male reproductive function and testicular apoptosis while bee bread has been traditionally consumed to enhance male fertility.Objective: The objective of this study was to determine the eff…
View article: CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection
CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection Open
View article: CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection
CYP450–mediated metabolites of aqueous leaves extract of Moringa oleifera inhibits absorption of chloroquine in Plasmodium yoeli yoeli infection Open
View article: Review on effects of obesity on male reproductive system and the role of natural products
Review on effects of obesity on male reproductive system and the role of natural products Open
Preliminary Anticancer Potency Evaluation and Phytochemical investigation of Methanol Extract of Piper claussenianum (Miq.) C. DC.André M. Marques, Renan A. de Paiva, Leonardo M. da Fonseca, Marcia A. M. Capella, Elsie F. Guimarães and Mar…