Batchimeg Usukhbayar
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View article: Detecting and quantifying clonal selection in somatic stem cells
Detecting and quantifying clonal selection in somatic stem cells Open
As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue function. When, and how, selection occurs in homeostatic tissues is incompletely understood. Here, we introduce SCIFER,…
View article: Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging
Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging Open
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations in genes, including DNMT3A and TET2 , conferring a competitive advantage through a mechanism that remains unclear. To gain insight into how CH mutations…
View article: Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia
Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia Open
Dysregulation of cellular differentiation is a hallmark of cancer. Isocitrate dehydrogenase (IDH) is commonly mutated multiple cancers including glioma, cholangiocarcinoma, lymphoma and Acute Myeloid Leukaemia (AML). Mutant IDH generates d…
View article: Heterogeneous genetic and non‐genetic mechanisms contribute to response and resistance to azacitidine monotherapy
Heterogeneous genetic and non‐genetic mechanisms contribute to response and resistance to azacitidine monotherapy Open
Acute myeloid leukaemia is prevalent in older patients that are often ineligible for intensive chemotherapy and treatment options remain limited with azacitidine being at the forefront. Azacitidine has been used in the clinic for decades, …
View article: Detecting and quantifying clonal selection in somatic stem cells
Detecting and quantifying clonal selection in somatic stem cells Open
As DNA variants accumulate in somatic stem cells, become selected or evolve neutrally, they may ultimately alter tissue function. When, and how, selection occurs in homeostatic tissues is incompletely understood. Here, we introduce SCIFER,…
View article: Mongol Familiarisation with European Medical Practices in the Nineteenth–Twentieth Centuries
Mongol Familiarisation with European Medical Practices in the Nineteenth–Twentieth Centuries Open
It was primarily Russian activities in Mongolia between 1860 and 1921, reflecting its geopolitical interests, that introduced European medical practices to the Mongols. Competing alongside other European powers, the Russian Government capi…
View article: Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay
Oncogenic Gata1 causes stage-specific megakaryocyte differentiation delay Open
The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down Syndrome (DS) occurs when N-terminal truncating mutations of the hemopoietic transcription factor GATA1, that produce GATA1short protein (GATA1s)…
View article: Oncogenic<i>Gata1</i>causes stage-specific megakaryocyte differentiation delay
Oncogenic<i>Gata1</i>causes stage-specific megakaryocyte differentiation delay Open
The megakaryocyte/erythroid Transient Myeloproliferative Disorder (TMD) in newborns with Down Syndrome (DS) occurs when N-terminal truncating mutations of the hemopoietic transcription factor GATA1, that produce GATA1short protein (GATA1s)…
View article: A NOVEL MODEL OF HUMAN LYMPHO-MYELOID PROGENITOR HIERARCHY BASED ON SINGLE CELL FUNCTIONAL AND TRANSCRIPTIONAL ANALYSIS
A NOVEL MODEL OF HUMAN LYMPHO-MYELOID PROGENITOR HIERARCHY BASED ON SINGLE CELL FUNCTIONAL AND TRANSCRIPTIONAL ANALYSIS Open
Human hemopoiesis produces 10 billion new, terminally mature, blood cells daily; a production that is also rapidly responsive to external change. Dysregulation of this complex process can lead to hemopoietic and immune deficiencies and blo…
View article: Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
Genetically distinct leukemic stem cells in human CD34− acute myeloid leukemia are arrested at a hemopoietic precursor-like stage Open
Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. In human acute myeloid leukemia (AML), current models suggest transformation creates leuk…