Bernhard T. Baune
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View article: From cigarettes to symptoms: the association between smoking and depression in the German National Cohort (NAKO)
From cigarettes to symptoms: the association between smoking and depression in the German National Cohort (NAKO) Open
Background Although the association between smoking and depression is well-established, the underlying mechanisms and contextual factors remain insufficiently understood. We examined the association between smoking and depression, includin…
View article: Epilepsy and mental health disorders: current challenges and potential solutions
Epilepsy and mental health disorders: current challenges and potential solutions Open
Summary Epilepsy affects ~50 million people worldwide and is associated with increased psychiatric comorbidities, including depression, anxiety, psychosis and suicidality. Despite this, current epilepsy management primarily focusses on sei…
View article: Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of <scp>PRS</scp> Moderation Effect: Findings From the <scp>PsyCourse</scp> Study
Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of <span>PRS</span> Moderation Effect: Findings From the <span>PsyCourse</span> Study Open
Introduction Bipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both me…
View article: 651. DISCOVERY OF OMICS-BIOMARKERS OF KETAMINE FOR TREATMENT RESPONSE IN DEPRESSION
651. DISCOVERY OF OMICS-BIOMARKERS OF KETAMINE FOR TREATMENT RESPONSE IN DEPRESSION Open
Background DNA methylation is a biomarker suited to investigate dynamic processes, such as treatment response. For this analysis we focus on DNA methylation changes during a randomised controlled trial (RCT) in treatment resistant depresse…
View article: A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits Open
Rare copy number variants (CNVs) are a key component of the genetic basis of psychiatric conditions, but have not been well characterized for most. We conducted a genome-wide CNV analysis across six diagnostic categories (N = 574,965): aut…
View article: Clinical predictors of treatment resistant depression
Clinical predictors of treatment resistant depression Open
Despite advances in the treatment of major depressive disorder (MDD) yet a substantial proportion of patients fail to achieve remission and instead develop treatment-resistant depression (TRD). Identifying robust clinical predictors of res…
View article: Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects
Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects Open
Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, incl…
View article: The role of the risk gene CACNA1C in neuroinflammation and peripheral immunity in autism spectrum disorder
The role of the risk gene CACNA1C in neuroinflammation and peripheral immunity in autism spectrum disorder Open
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, restricted and repetitive behaviors and interests, with the severity of symptoms varying greatly…
View article: Intranasal esketamine significantly alleviates depression severity and suicidal ideations in electroconvulsive therapy (ECT) non-responders
Intranasal esketamine significantly alleviates depression severity and suicidal ideations in electroconvulsive therapy (ECT) non-responders Open
Introduction Intranasal esketamine (ESK) is a novel therapy option in patients with treatment-resistant depression (TRD). Patients with a history of electroconvulsive therapy (ECT) non-response (ECT+) in the current episode have usually be…
View article: Immune DNA methylation in depression: cross-sectional and longitudinal study
Immune DNA methylation in depression: cross-sectional and longitudinal study Open
Background Immune dysregulation contributes to the pathophysiology of depression and is a potential link between depression and comorbid medical conditions. DNA methylation is a dynamic transcriptional regulator of the immune system. Aims …
View article: DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial
DNA methylation changes in a pharmaco-epigenomic EWAS in depression: comparing fixed and response-guided dosing paradigms for ketamine in the KADS trial Open
DNA methylation is a dynamic biomarker suited to investigate processes, e.g., treatment response. We investigate DNA methylation changes in different dosing paradigms for ketamine (s.c.) vs. midazolam (s.c.) in treatment resistant depresse…
View article: Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review
Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review Open
Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities. While microglia have traditionally been the focu…
View article: Correction: Mild motor signs and depression: more than just medication side effects?
Correction: Mild motor signs and depression: more than just medication side effects? Open
In this article the author’s name Raffaele Ferri was incorrectly written as Raffaella Ferri. The original article has been corrected.
View article: Moving toward precision and personalized treatment strategies in psychiatry
Moving toward precision and personalized treatment strategies in psychiatry Open
Precision psychiatry aims to improve routine clinical practice by integrating biological, clinical, and environmental data. Many studies have been performed in different areas of research on major depressive disorder, bipolar disorder, and…
View article: Modelling approaches to examine biomarkers and diabetes status among older Australians
Modelling approaches to examine biomarkers and diabetes status among older Australians Open
This paper investigates the association between potential serum biomarkers and diabetes status in older Australians by employing traditional and machine learning methods. Data from Sydney Memory and Ageing Study (MAS) were interrogated cro…
View article: Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)
Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN) Open
Clozapine is highly effective for treatment-resistant schizophrenia but is underutilized due to patient and clinician-related concerns. Little is known about the general level of patient satisfaction with clozapine and determinants thereof…
View article: Identification of blood eQTLs in older adults
Identification of blood eQTLs in older adults Open
Genome-wide association studies (GWAS) have been successful in identifying genetic variation associated with a wide range of phenotypes. However, more detailed knowledge of their functional significance is required to provide insights into…
View article: Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study
Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study Open
Background Anxiety disorders and treatment-resistant major depressive disorder (TRD) are often comorbid. Studies suggest ketamine has anxiolytic and antidepressant properties. Aims To investigate if subcutaneous racemic ketamine, delivered…
View article: Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review
Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review Open
Major depressive disorder (MDD) shows a large heterogeneity in antidepressant treatment outcome, a variability explained in part by common-variant liability captured by polygenic scores (PGSs). We performed a review of PubMed- and Google S…
View article: A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe
A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe Open
Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and tr…
View article: A bibliometric analysis of studies on environmental enrichment spanning 1967–2024: patterns and trends over the years
A bibliometric analysis of studies on environmental enrichment spanning 1967–2024: patterns and trends over the years Open
Environmental Enrichment (EE) has received considerable attention for its potential to enhance cognitive and neurobiological outcomes in animal models. This bibliometric analysis offers a comprehensive evaluation of the EE research spannin…
View article: Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk‐Locus Xq28,distal
Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk‐Locus Xq28,distal Open
Duplications of the Xq28,distal locus have been described in male and female patients with schizophrenia (SCZ) or intellectual disability. The Xq28,distal locus spans eight protein-coding genes (F8, CMC4, MTCP1, BRCC3, VBP1, FUNDC2, CLIC2,…