Benjamin Béland
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Refractory myasthenia gravis treated with autologous hematopoietic stem cell transplantation Open
Objectives Patients with refractory myasthenia gravis (MG) have few treatment options. Autologous hematopoietic stem cell transplantation (HSCT) has been used to treat immune diseases; however, its use in the treatment of MG is not broadly…
View article: Management Approaches to Intraluminal Thrombi in Acutely Symptomatic Carotid Stenosis
Management Approaches to Intraluminal Thrombi in Acutely Symptomatic Carotid Stenosis Open
Background: The presence of an intraluminal thrombus in acutely symptomatic carotid stenosis is thought to represent a high-risk lesion for short-term stroke reccurrence though evidence on natural history and treatment is lacking, leading …
No sex‐based differences in odds of starting or time to treatment of generalized myasthenia gravis: A single center cohort study Open
Introduction/Aims Females with generalized myasthenia gravis (gMG) report lower quality of life (QoL) and have more severe disease than males. Sex differences in disease characteristics exist, however whether there are sex differences in t…
View article: Reperfusion therapies for ischemic stroke in dementia and cognitive impairment: A systematic review and meta-analysis
Reperfusion therapies for ischemic stroke in dementia and cognitive impairment: A systematic review and meta-analysis Open
Background: Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) have an unclear benefit in those with pre-stroke dementia or cognitive impairment, as these patients were often excluded from landmark stroke trials. We perform…
Recessive Pathogenic <i>GMPPB</i> Variants Cause a Childhood Onset Myasthenic Syndrome Responsive to Pyridostigmine Open
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P.035 Autologous hematopoietic stem cell transplant for the treatment of refractory myasthenia gravis with anti-muscle specific kinase antibodies Open
Background: Several case series describe patients with refractory acetylcholine receptor antibody-positive (AChR) myasthenia gravis (MG) treated with hematopoietic stem cell transplant (HSCT). In this report, we describe four patients with…
View article: P.067 The decision to revascularize in symptomatic non-stenotic carotid disease: results from the Hot Carotid Qualitative study
P.067 The decision to revascularize in symptomatic non-stenotic carotid disease: results from the Hot Carotid Qualitative study Open
Background: Little evidence exists to guide the management of symptomatic non-stenotic carotid disease (SyNC). SyNC, which refers to carotid lesions with less than 50% artery stenosis, has been increasingly implicated as a cause of stroke …
P.036 Are there sex differences in the treatment of myasthenia gravis? a single centre cohort study Open
Background: Females with generalized myasthenia gravis (gMG) report lower quality of life (QoL) compared to males. Our objective was to determine whether sex differences in treatment and time to treatment initiation may contribute to this …
View article: Physician Approaches to Antithrombotic Therapies for Recently Symptomatic Carotid Stenosis
Physician Approaches to Antithrombotic Therapies for Recently Symptomatic Carotid Stenosis Open
Background: Whereas the beneficial effect of antiplatelet therapy for recurrent stroke prevention has been well established, uncertainties remain regarding the optimal antithrombotic regimen for recently symptomatic carotid stenosis. We so…
Autologous hematopoietic stem cell transplant for the treatment of refractory myasthenia gravis with <span>anti‐muscle</span> specific kinase antibodies Open
Introduction/Aims Up to 25% of patients with myasthenia gravis (MG) have refractory disease despite trials of multiple immunosuppressants. Several case series describe acetylcholine receptor antibody‐positive (AChR) MG patients treated wit…
Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability: A Meta-Analysis Open
Background: Randomized controlled trials for the use of alteplase in acute ischemic stroke have excluded or had little representation of patients with prestroke disability, and the benefit of alteplase in this population remains uncertain.…
P.063 Thrombolysis for acute ischemic stroke in patients with pre-morbid disability: a meta-analysis Open
Background: Randomized-controlled trials of thrombolysis in ischemic stroke have poorly represented patients with pre-stroke disability and the benefit of thrombolysis in this population remains uncertain. We performed a systematic review …
P.062 Physician approaches to anti-thrombotic therapies, imaging and revascularization for acutely symptomatic carotid stenosis: a hot carotid qualitative study Open
Background: There are uncertainties regarding the optimal management of acutely symptomatic carotid stenosis (“hot carotids”). We sought to explore the approaches of stroke physicians to anti-thrombotic management, imaging, and revasculari…
P.044 GMPPB mutation causes a muscular dystrophy-myasthenic spectrum Open
Background: Mutations in GDP-Mannose Pyrophosphorylase B (GMPPB) cause a spectrum of disease ranging from muscular dystrophy to congenital myasthenic syndrome (CMS). Recognition of neuromuscular junction dysfunction has important treatment…
View article: Physician Approaches to Imaging and Revascularization for Acutely Symptomatic Carotid Stenosis: Insights from the Hot Carotid Qualitative Study
Physician Approaches to Imaging and Revascularization for Acutely Symptomatic Carotid Stenosis: Insights from the Hot Carotid Qualitative Study Open
Background Evidence informing the choice between carotid endarterectomy and carotid artery stenting for acutely symptomatic carotid stenosis (“hot carotid”) is dated and does not factor in contemporary therapies or techniques. The optimal …
P.064 Physician Approaches to Imaging and Revascularization for Acutely Symptomatic Carotid Stenosis: Insights from the Hot Carotid Qualitative Study Open
Background: Evidence informing the choice between endarterectomy and stenting for acutely symptomatic carotid stenosis (“hot carotid”) is dated, and uncertainties remain regarding the optimal imaging modality. We sought to explore the thou…
View article: P.065 Physician Approaches to Anti-thrombotic Therapies for Acutely Symptomatic Carotid Stenosis: Insights from the Hot Carotid Qualitative Study
P.065 Physician Approaches to Anti-thrombotic Therapies for Acutely Symptomatic Carotid Stenosis: Insights from the Hot Carotid Qualitative Study Open
Background: Whereas the beneficial effect of antiplatelet therapy for recurrent stroke prevention is well-established, uncertainties remain regarding the optimal anti-thrombotic regimen for acutely symptomatic carotid stenosis (“hot caroti…
P.063 Endovascular Treatment of Acute Ischemic Stroke in Patients with Pre-morbid Disability: A Meta-analysis Open
Background: Practice-changing trials of endovascular thrombectomy (EVT) for acute stroke excluded patients with pre-morbid disability. Observational studies may inform the role of EVT in this population. We performed a meta-analysis to est…
View article: CJN volume 47 issue 3 Cover and Front matter
CJN volume 47 issue 3 Cover and Front matter Open
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View article: Fentanyl Overdose Causing Hippocampal Ischaemia Followed by Delayed Leukoencephalopathy
Fentanyl Overdose Causing Hippocampal Ischaemia Followed by Delayed Leukoencephalopathy Open
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P.092 The effect of the timing of surgery on outcomes for incidental low-grade gliomas: a systematic review Open
Background: Although previous research has suggested that patients with incidentally discovered low-grade gliomas (iLGG) who undergo surgery prior to the appearance of symptoms have improved outcomes compared to those who are symptomatic, …
The Effect of Thoracolumbar Pedicle Isthmus on Pedicle Screw Accuracy Open
Study Design: Retrospective analysis. Objectives: Aberrant pedicle screws can cause serious neurovascular complications. We propose that a predominant factor of pedicle screw breach is the vertebral anatomy at a given spinal level. We aim …
Point-of-care wound visioning technology: Reproducibility and accuracy of a wound measurement app Open
The Swift Wound app provides highly reliable and accurate wound measurements. The FLIR™ infrared camera integrated into the Swift Wound app provides skin temperature readings equivalent to the clinically tested reference thermometer. Thus,…