Bennett A. Landman
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View article: Bridging Histology and Tractography: First Visualization of the Short-Range Prefrontal Connections in the Human Brain
Bridging Histology and Tractography: First Visualization of the Short-Range Prefrontal Connections in the Human Brain Open
Decades of histological research in non-human primates have revealed a dense web of short- range connections underpinning prefrontal cortex (PFC) function. However, translating this anatomical ground-truth to the living human brain has bee…
View article: Sensitivity of quantitative diffusion MRI tractography and microstructure to anisotropic spatial sampling
Sensitivity of quantitative diffusion MRI tractography and microstructure to anisotropic spatial sampling Open
Fractional anisotropy and mean diffusivity cannot be recovered with basic up-sampling from low quality data with gold-standard data with the methods selected for this study. However, the bundle measures across our selected regions of inter…
View article: MSRepaint: Multiple Sclerosis Repaint with Conditional Denoising Diffusion Implicit Model for Bidirectional Lesion Filling and Synthesis
MSRepaint: Multiple Sclerosis Repaint with Conditional Denoising Diffusion Implicit Model for Bidirectional Lesion Filling and Synthesis Open
In multiple sclerosis, lesions interfere with automated magnetic resonance imaging analyses such as brain parcellation and deformable registration, while lesion segmentation models are hindered by the limited availability of annotated trai…
View article: Lifespan Trajectories of Asymmetry in White Matter Tracts
Lifespan Trajectories of Asymmetry in White Matter Tracts Open
Asymmetry in white matter is believed to give rise to the brain's capacity for specialized processing and is involved in the lateralization of various cognitive processes, such as language and visuo-spatial reasoning. Although studies of w…
View article: Self-supervised learning of imaging and clinical signatures using a multimodal joint-embedding predictive architecture
Self-supervised learning of imaging and clinical signatures using a multimodal joint-embedding predictive architecture Open
The development of multimodal models for pulmonary nodule diagnosis is limited by the scarcity of labeled data and the tendency for these models to overfit on the training distribution. In this work, we leverage self-supervised learning fr…
View article: Secondary use of radiological imaging data: Vanderbilt’s ImageVU approach
Secondary use of radiological imaging data: Vanderbilt’s ImageVU approach Open
ImageVU demonstrates a scalable and efficient approach for integrating clinical imaging into research workflows. By combining institutional data infrastructure with cloud-based storage and metadata-driven cohort identification, the platfor…
View article: Learn2Reg 2024: New Benchmark Datasets Driving Progress on New Challenges
Learn2Reg 2024: New Benchmark Datasets Driving Progress on New Challenges Open
Medical image registration is critical for clinical applications, and fair benchmarking of different methods is essential for monitoring ongoing progress. To date, the Learn2Reg 2020-2023 challenges have released several complementary data…
View article: Early adipose tissue wasting in a preclinical model of human lung cancer cachexia
Early adipose tissue wasting in a preclinical model of human lung cancer cachexia Open
Cancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between preclinical models and h…
View article: JMI’s Special Issues and Shared Journeys
JMI’s Special Issues and Shared Journeys Open
The editorial discusses current JMI special sections/issues and calls for papers.
View article: Lifespan Pancreas Morphology for Control vs Type 2 Diabetes using AI on Largescale Clinical Imaging
Lifespan Pancreas Morphology for Control vs Type 2 Diabetes using AI on Largescale Clinical Imaging Open
Purpose: Understanding how the pancreas changes is critical for detecting deviations in type 2 diabetes and other pancreatic disease. We measure pancreas size and shape using morphological measurements from ages 0 to 90. Our goals are to 1…
View article: Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets
Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets Open
Thorough quality control (QC) can be time consuming when working with large-scale medical imaging datasets, yet necessary, as poor-quality data can lead to erroneous conclusions or poorly trained machine learning models. Most efforts to re…
View article: Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study
Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study Open
Background Effective data management is crucial in clinical studies for precise tracking, secure storage, and reliable analysis of samples. Traditional systems often encounter challenges like barcode recognition errors, inadequate data det…
View article: Robust Containerization of the High Angular Resolution Functional Imaging (HARFI) Pipeline
Robust Containerization of the High Angular Resolution Functional Imaging (HARFI) Pipeline Open
Historically, functional magnetic resonance imaging (fMRI) of the brain has focused primarily on gray matter, particularly the cortical gray matter and associated nuclei. However, recent work has demonstrated that functional activity in wh…
View article: White Matter Geometry Confounds Diffusion Tensor Imaging Along Perivascular Space (DTI‐ALPS) Measures
White Matter Geometry Confounds Diffusion Tensor Imaging Along Perivascular Space (DTI‐ALPS) Measures Open
The perivascular space (PVS) is integral to glymphatic function, facilitating fluid exchange and waste clearance in the brain. Diffusion tensor imaging along the perivascular space (DTI‐ALPS) has been proposed as a noninvasive marker of pe…
View article: Summer of Ideas, Community, and Recognition
Summer of Ideas, Community, and Recognition Open
The editorial celebrates emerging breakthroughs and the foundational work that continues to shape the field.
View article: White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease Open
Importance There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD). Objective To investigate the associations between…
View article: Microstructural Characterization of Short Association Fibers Related to Long‐Range White Matter Tracts in Normative Development
Microstructural Characterization of Short Association Fibers Related to Long‐Range White Matter Tracts in Normative Development Open
Short association fibers (SAFs) in the superficial white matter play a key role in mediating local cortical connections but have not been well‐studied as innovations in whole‐brain diffusion tractography have only recently been developed t…
View article: The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers
The association between poor sleep health and Alzheimer's disease structural neuroimaging biomarkers Open
INTRODUCTION Poor sleep may be a risk factor for neurodegeneration and Alzheimer's disease (AD). Few studies have examined objectively measured sleep with structural neuroimaging measures. METHODS Vanderbilt Memory and Aging Project partic…
View article: Fixel-Based Analysis Identifies Selective Vulnerability of Non-Dominant Fiber Populations in Aging and Cognitive Decline
Fixel-Based Analysis Identifies Selective Vulnerability of Non-Dominant Fiber Populations in Aging and Cognitive Decline Open
Fixel-Based Analysis (FBA) offers a novel framework to disentangle fiber-specific white matter (WM) degeneration, particularly within complex crossing-fiber architecture where conventional diffusion tensor imaging (DTI) falls short. In thi…
View article: Multipath cycleGAN for harmonization of paired and unpaired low-dose lung computed tomography reconstruction kernels
Multipath cycleGAN for harmonization of paired and unpaired low-dose lung computed tomography reconstruction kernels Open
Reconstruction kernels in computed tomography (CT) affect spatial resolution and noise characteristics, introducing systematic variability in quantitative imaging measurements such as emphysema quantification. Choosing an appropriate kerne…
View article: The relationship of white matter tract orientation to vascular geometry in the human brain
The relationship of white matter tract orientation to vascular geometry in the human brain Open
The white matter of the human brain exhibits highly ordered anisotropic structures of both axonal nerve fibers and cerebral vasculature. Separately, the anisotropic nature of white matter axons and white matter vasculature have been shown …
View article: Rep3D: Re-parameterize Large 3D Kernels with Low-Rank Receptive Modeling for Medical Imaging
Rep3D: Re-parameterize Large 3D Kernels with Low-Rank Receptive Modeling for Medical Imaging Open
In contrast to vision transformers, which model long-range dependencies through global self-attention, large kernel convolutions provide a more efficient and scalable alternative, particularly in high-resolution 3D volumetric settings. How…
View article: Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease
Genetic architecture of the limbic white matter microstructure in aging and Alzheimer’s Disease Open
Background Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer’s disease (AD), yet their underlying biological mechanisms remain unclear. This study aims to identify the genetic architecture of limbic WM microstruct…
View article: Longitudinal Masked Representation Learning for Pulmonary Nodule Diagnosis from Language Embedded EHRs
Longitudinal Masked Representation Learning for Pulmonary Nodule Diagnosis from Language Embedded EHRs Open
Electronic health records (EHRs) are a rich source of clinical data, yet exploiting longitudinal signals for pulmonary nodule diagnosis remains challenging due to the administrative noise and high level of clinical abstraction present in t…
View article: White matter microstructure and macrostructure brain charts across the human lifespan
White matter microstructure and macrostructure brain charts across the human lifespan Open
Normative reference charts are widely used in healthcare, especially for assessing the development of individuals by benchmarking anatomic and physiological features against population trajectories across the lifespan. Recent work has exte…
View article: Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity
Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity Open
INTRODUCTION Sedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults. METHODS Vanderbilt Memory and A…
View article: Influence of early through late fusion on pancreas segmentation from imperfectly registered multimodal magnetic resonance imaging
Influence of early through late fusion on pancreas segmentation from imperfectly registered multimodal magnetic resonance imaging Open
Fusion in specific blocks can improve performance, but the best blocks for fusion are model-specific, and the gains are small. In imperfectly registered datasets, fusion is a nuanced problem, with the art of design remaining vital for unco…